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| 1 | Botulinum toxin injections after surgery for Hirschsprung disease:Systematic review and meta-analysis显示文摘BACKGROUND A large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective surgery.Persistent obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis,a potential life-threatening condition.Important treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin injections.AIM To give an overview of all empirical evidence on the effectiveness of botulinum toxin injections in patients with Hirschsprung disease.METHODS A systematic review and meta-analysis was done by searching PubMed,EMBASE and the Cochrane Library,using entry terms related to:(1)Hirschsprung disease;and(2)Botulinum toxin injections.14 studies representing 278 patients met eligibility criteria.Data that were extracted were proportion of patients with improvement of obstructive symptoms or less enterocolitis after injection,proportion of patients with adverse effects and data on type botulinum toxin,mean dose,average age at first injection and patients with associated syndromes.Random-effects meta-analysis was used to aggregate effects and random-effects meta-regression was used to test for possible confounding factors.RESULTS Botulinum toxin injections are effective in treating obstructive symptoms in on average 66%of patients[event rate(ER)=0.66,P=0.004,I2=49.5,n=278 patients].Type of botulinum toxin,average dose,average age at first injections and proportion of patients with associated syndromes were not predictive for this effect.Mean 7 duration of improvement after one botulinum toxin injections was 6.4 mo and patients needed on average 2.6 procedures.There was a significant higher response rate within one month after botulinum toxin injections compared to more than one month after Botulinum toxin injections(ER=0.79,vs ER=0.46,Q=19.37,P<0.001).Botulinum toxin injections were not effective in treating enterocolitis(ER 0.58,P=0.65,I2=71.0,n=52 patients).There were adverse effects in on average 17%of patients(ER=0.17,P<0.001,I2=52.1,n=187 patients),varying from temporary incontinence to mild anal pain.CONCLUSION Findings from this systematic review and meta-analysis indicate that botulinum toxin injections are effective in treating obstructive symptoms and that adverse effects were present,but mild and temporary. | Danielle Roorda Zarah AM Abeln Jaap Oosterlaan Lodewijk WE van Heurn Joep PM Derikx | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 2 | Response inhibition and response re-engagement in attention-deficit/hyperactivity disorder, disruptive, anxious and normal children显示文摘 | OOSTERLAAN J SERGEANT J A | 1998 | Behavioural brain re arch1998，94，1： | 1 |
| 3 | How Specific is a Deficit of Executive Functioning for Attention -Deficit / Hyperactivity Disorder显示文摘 | Geurts H Oosterlaan J | 2002 | Behav Brain Res2002，，130： | 1 |
| 4 | Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families显示文摘 | Rommelse NN Altink ME Oosterlaan J | 2008 | Psychol Med2008，38，11： | 1 |
| 5 | Effects of neonatal enteral glutamine supplementation on cognitive,motor and behavioural outcomes in very preterm and/or very low birth weight children at school age显示文摘 | De Kieviet JF Oosterlaan J van Zwol A Boehm G Lafeber HN van Elburg RM | 2012 | Br J Nutr2012，108，12： | 1 |
| 6 | Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families显示文摘 | Rommelse N N Altink M E Oosterlaan J | 2008 | Psychol Med2008，38，11： | 1 |
| 7 | How specific is a deficit of executive functioning for Attention-Deficit/Hyperactivity Disorder?显示文摘 | Joseph A Sergeant Hilde Geurts Jaap Oosterlaan | 2002 | Behavioural Brain Research2002，，1： | 1 |
| 8 | ADHD subtypes:do they differ in their executive functioning profile显示文摘 | Geurts HM Verte S Oosterlaan J | 2005 | Arch Clin Neuropsychol2005，20，4： | 1 |
| 9 | The impact of reinforcement contingencies on AD/HD:A review and theoretical appraisal显示文摘 | LUMAN M OOSTERLAAN J SERGEANT JA | 2005 | Clin Psychol Rev2005，25，4： | 1 |
| 10 | Efficacy of methylphenidate,psychosocial treatments and their combination in school-aged children with ADHD:a meta-analysis显示文摘 | Van der Oord S Prins PJM Oosterlaan J | 2008 | Clinical Psychology Review2008，28，5： | 1 |
| 11 | Inhibition in ADHA,Aggressive,and Anxious Children:A Bilogiccally Based Model of Psychology 显示文摘 | OOSTERLAAN J SERGEANT J A | 1996 | Journal of Abnormal Child Psychology1996，24，1： | 1 |
| 12 | Neurocognitive func- tions in pathological gambling:A comparison with alcohol dependence,Tourette syndrome and normal controls 显示文摘 | Goudriaan A E Oosterlaan J deBeurs E | 2006 | Addiction2006，101，4： | 1 |
| 13 | The Stroop revisited: A meta-analysis of interference control in AD/HD 显示文摘 | Van Mourik R Oosterlaan J Sergeant JA | 2005 | J Child Psy- chol Psychiatry2005，46，2： | 1 |
| 14 | Neurocognitivefunctions in pathological gambling: a comparison with alcohol de- pendence,Tourette syndrome and normal controls 显示文摘 | Goudrlaan AE Oosterlaan J de Beurs E | 2006 | Addiction2006，101，4： | 1 |
| 15 | Neurocognitive functions in pathological gambling:A comparison with alcohol dependence,Tourette syndrome and normal controls显示文摘 | Goudriaan A E Oosterlaan J deBeurs E et a1 | 2006 | Addiction2006，101，4： | 1 |
| 16 | Executive functioning in adult ADHD:a meta-analytic review显示文摘 | Boonstra AM Oosterlaan J Sergeant JA | 2005 | Psychol Med2005，35，8： | 1 |
| 17 | To act or not to act, that's the problem: primarily inhibition difficulties in adult ADHD 显示文摘 | Boonstra AM Kooij JJ Oosterlaan J | 2010 | Neuropsychology2010，24，2： | 1 |
| 18 | How Specific Is A Deficit of Executive Functioning for Attention-deficit/Hyperactivity Disorder-显示文摘 | Sergeant J A Geurts H Oosterlaan J | 2002 | Behavioural Brain Research2002，130，12： | 1 |
| 19 | Effects of neo- natal enteral glutamine supplementation on cognitive, motor and behaviourai outcomes in very preterm and/or very low birth weight children at school age显示文摘 | de Kieviet JF Oosterlaan J van Zwol A | 2012 | The British Journal of Nutrition2012，108，12： | 1 |
| 20 | Response inhibition and measures of psychopathology:a dimensional analysis显示文摘 | Kooijmans R Scheres A Oosterlaan J | 2000 | Child Neuropsychol2000，6，： | 1 |
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