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| 1 | Multiple Mating and Reproductive Success of Male and Female Apple Maggot Flies, Rhagoletis pomonella ( Diptera : Tephritidae) 显示文摘 | Opp S B Prokopy R J | 2000 | Journal of Insect Behavior2000，13，6： | 1 |
| 2 | Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism显示文摘We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immunogenicity.In this study,we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod(a Toll-like receptor 7/8 agonist)covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase,α-mannosidase,or β-galactosidase.We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase.At a cellular level,we examined EDI metabolism across three cancer cell lines(B16 melanoma,TC2 prostate,and 4T1 breast cancer).Comparing the relative immunogenicity elicited by each EDI/cancer cell combination,we found that B16 cells produced the highest EDI prodrug immunogenicity,achieving>95% of that elicited by unmodified resiquimod,followed by TC2 and 4T1 cells(40% and 30%,respectively).Immunogenicity elicited was comparable for a given cell type and independent of the glycosidase substrate in the EDIs or differences in functional glycosidase activity between cell lines.Measuring drug efflux of the immunostimulant payload and efflux protein expression revealed that EDI/cancer cell-mediated immunogenicity was governed by efflux potential of the cancer cells.We determined that,following EDI conversion,immunostimulant efflux occurred through both P-glycoprotein-dependent and P-glycoprotein-independent transport mechanisms.Overall,this study highlights the broad ability of EDIs to couple immunogenicity to the metabolism of many cancers that exhibit drug efflux and suggests that designing future generations of EDIs with immunostimulant payloads that are optimized for drug efflux could be particularly beneficial. | Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini | 2020 | Acta Pharmacologica Sinica2020，41，7： | 1 |
| 3 | Levetiracetam in children with refractory epilepsy: a multicenter open label study in Germany 显示文摘 | Opp J Tuxhorn I May T Kluger G Wiemer-Kruel A Kurlemann G | 2005 | Seizure2005，14，7： | 1 |
| 4 | Variation in laboratory oviposition by Rhagoletis pomonella (Diptera: Tephritidae) in relation to mating status显示文摘 | Opp S B Prokopy R J | 1986 | Annals of the Entomological Society of America1986，79，4： | 1 |
| 5 | Factors Influencing Estimates of Sperm Competition in Rhagoletis pomonella (Walsh) ( Diptera : Tephritidae) 显示文摘 | Opp S B Ziegner J Bui N | 1990 | Annals of the Entomological Society of America1990，83，3： | 1 |
| 6 | Levetiracetam in children with refractory epilepsy:a multicenter open label study in Germany显示文摘 | Opp J Tuxhom I May T | | 0，，07： | 1 |
| 7 | IL-1 is involved in responses to sleep deprivation in rabbit显示文摘 | OPP M R KRUEGER J M | 1994 | Brain Research1994，639，： | 1 |
| 8 | Anti-IL-1β reduces sleep rebound after sleep deprivation in rats 显示文摘 | OPP M R KRUEGER J M | 1994 | Am J Physiol1994，266，： | 1 |
| 9 | Use of electric cell-substrateimpedance sensing to assess in vitro cytotoxicity显示文摘 | Opp D Wafula B Lim J | 2009 | BiosensBioelectron2009，24，8： | 1 |
| 10 | Interleukin 1 receptor antagonist blocks somnogenie and pyrogenie responses to an interleukin I fragment显示文摘 | Opp M R Postlethwaite A E Seyer J M | 1992 | Proe Nat/Acad Sei USA1992，89，9： | 1 |
| 11 | Discontinuous molecular dynamics (DMD) study of heteropolymer collapse in an explicit solvent显示文摘 | Opps S B Rilling K M Poison J M | 2013 | Cell Biochemistry and Biophysics2013，66，1： | 1 |
| 12 | Use of electric cell-sub- strate impedance sensing to assess in vitro cytotoxicity 显示文摘 | Opp D Wafula B Lim J | 2009 | Biosens Bioelectron2009，24，8： | 1 |
| 13 | Oxcarbazepine-in- duced hyponatremia and the regulation of serum sodium after replacing carbamazepine with oxcarbazepine in children 显示文摘 | Holtmann M Krause M Opp J | 2002 | Neuropediatrics2002，33，6： | 1 |
| 14 | Anti- IL- 1β reduces sleep rebound after sleep deprivateon in rats 显示文摘 | OPP M R KRUEGER J M | 1994 | Am J Physiol1994，266，2： | 1 |
| 15 | An IL- 1 receptor and an IL- 1 receptor antagnist attenyate muramyl dipeptide IL- 1 -induced sleep and fever显示文摘 | IMERI L OPP M R KRUEGER J M | 1993 | Am J Physiol1993，265，6： | 1 |
| 16 | Anti-IL-1 βreduces sleep and sleep rebound after sleep deprivation in rats 显示文摘 | Opp M R Krueger J M | 1994 | Am J Physiol1994，266，： | 1 |
| 17 | Local anesthesia in minor lacerations:Topieal TAC vs lidocaine infiltration显示文摘 | Pryor G J Kilpatrick WR Opp DR | 1980 | Ann Emerg Med1980，9，： | 1 |
| 18 | Zeptosens' Protein M ieroarrays,a Novel High Performance M icroarray Platform for Low Abundance Protein Analysis 显示文摘 | Pawlak M E Schick M A B opp M J | 2002 | Proteomics2002，2，4： | 1 |
| 19 | Properties of dental eastability of Ti and Ti-6Al-4V 显示文摘 | Greener E H Moser J B Opp J | 1986 | Dent Res1986，，65： | 1 |
| 20 | Levetiracetam in children with refractory epilepsy:a multicenter open label study in Germany显示文摘 | Opp J Tuxhorn I May T | 2005 | Seizure2005，14，： | 1 |
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