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| 1 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 2 | Bacterial and viral superantigens: roles in autoimmunity显示文摘 | Acha Orbea H | 1993 | Ann Rheum Dis1993，52，1： | 1 |
| 3 | Inte- ractive effects of benzo(a) pyrene and cadmium and effects of di (2- ethylhexyl ) phthalate on antioxidant and peroxisomal enzymes and peroxisomal volume density in the digestive gland of mussel mytilus galloprovincialis Lmk显示文摘 | ORBEA A ORTIZ-ZARRAGOITIA M CAJARAVILLE M P | 2002 | Biomarkers2002，7，1： | 1 |
| 4 | Interactive effects of benzoa pyrene and cadmium and effects of di(2-ethylhexyl) phthalate on antioxidant and peroxisomal enzymes and peroxisomal volume density in the digestive gland of mussel Mytilus galloprovincialis Lmk显示文摘 | Orbea A Ortiz-Zarragoitia M Cajaraville MP | 2002 | Biomarkers2002，7，1： | 1 |
| 5 | Antioxidant enzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve molluscs,crabs and fish from the Urdaibai and Plentzia estuaries (Bay of Biscay)显示文摘 | Orbea A Ortiz-Zarragoitia M Sole M | 2002 | Aqua Toxicol2002，58，： | 1 |
| 6 | Limited heterogeneity of T cell receptors from lymphocyte mediating autoimmune encephalomyelitis allows specific immune intervention 显示文摘 | Mitchell DJ Timmerman L | 1988 | Cell1988，54，2： | 1 |
| 7 | Effects ofthe Prestige oil spill on cellular biomarkers in intertidal mussels-results of first year of studies 显示文摘 | ORBEA A GARMENDIA L MARIG6MEZ I | 2006 | Marine Ecology Progress Se-ries2006，306，： | 1 |
| 8 | Peroxisome proliferation and antioxidant enzymes in transplanted mussels of four basque estuaries with different levels of polycyclic aro?matic hydrocarbon and polychlorinated biphenyl pollu?tiGn显示文摘 | Orbea A Cajaraville M P | 2006 | Environmental Toxicology Chemistry2006，25，6： | 1 |
| 9 | Antioxidant enzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve molluscs, crabs and fish from the Urdaibai and Plentzia estuaries (Bay of Biscay) 显示文摘 | Orbea A Ortiz-Zarragoitia M Sole M | 2002 | Aquatic Toxicology2002，58，12： | 1 |
| 10 | Antioxidant enzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve molluscs,crabs and fish from the Urdaibai and Plentzia estuaries(Bay of Biscay)显示文摘 | ORBEA A ORTIZ-ZARRAGOITIA M SOLE'M | 2002 | Aquatic Toxicology2002，58，： | 1 |
| 11 | Antioxidantenzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve molluscs, crabs and fish from the Urdaibai and Plentzia estuaries ( Bay of Biscay) 显示文摘 | Orbea A Ortiz-Zarragoitia M So16 M | 2002 | Aquatic Toxicology2002，58，12： | 1 |
| 12 | Antioxidant enzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve molluscs,crabs and fish from the Urdaibai and Plentzia estuaries (Bay of Biscay)显示文摘 | Orbea A Ortiz-Zarragoitia M Sole M | | 0，，1： | 1 |
| 13 | Antioxidant enzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve mollusks, crabs and fish from the Urdaibai and Plentzia estuaries (Bay of Biscay)显示文摘 | Orbea A Ortiz-Zarragoitia M Sole' M | 2002 | Aquatic Toxicology2002，58，12： | 1 |
| 14 | Immunolocalization of four antioxidant enzymes in digestive glands of mollusks and crustaceans and fish liver 显示文摘 | Orbea A Fahimi H D CajaraviUe MP | 2000 | Histochem Cell Biol2000，114，5： | 1 |
| 15 | Peroxisome protiferation in the digestive epithetium of mussels esposed to the water accommodated fraction of three oils显示文摘 | CAJARVIIL M P ORBEA A MANIGOMEZ I | 1997 | Compourative Biochemistry and Physillogy1997，117，： | 1 |
| 16 | Peroxisome proliferation as a biomarker in environmental pollution assessment 显示文摘 | Cajaraville M P Orbea A Ibabe A | 2003 | Micros Res Tech2003，61，： | 1 |
| 17 | Antioxidant enzymes and peroxisome proliferation in relation to contaminant body burdens of PAHs and PCBs in bivalve molluscs,crabs and fish from the Urdaibai and Plentzia estuaries(Bay of Biscay)显示文摘 | Orbea A Ortiz-Zarragoitia M SoléM | 2002 | Aquatic Toxicology2002，58，1： | 1 |
| 18 | Immunoloealization of four antioxidant enzymes in digestive glands of mollusks and crus-taceans and fish liver显示文摘 | Orbea A Fahimi H D Cajaraville M P | 2000 | Histochem Cell Bio2000，114，5： | 1 |
| 19 | Can MMTV exploit TLR4? 显示文摘 | Otten IA Finke D Acha orbea H | 2002 | Trends Microbiol2002，10，7： | 1 |
| 20 | Immunolocalization of four antioxidant enzymes in digestive glands of mollusksand crustaceans and fish liver 显示文摘 | Orbea A Fahimi H D Cajaraville M P | 2000 | Histoclaem Cell Biol2000，114，： | 1 |
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