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30篇 您的检索式:作者名="Ordieres"
    题名 作者 年代 出处 被引量
1Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz 2021Bioactive Materials2021,6,12:7
2Animal models for endoscopic training: do we really need them?显示文摘A. Parra-Blanco N. Gonz??lez R. Gonz??lez J. Ortiz-Fern??ndez-Sordo C. Ordieres 2013Endoscopy2013,,06:1
3Determination of dimethylamine in groundwater by liquid chromatography and precolumn derivatization with 9-fluorenylmethylchloroformate显示文摘Margarita Rodriguez Lopez Maria Jose Gonzalez Alvarez Arturo J Miranda Ordieres 1996J Chromatogr A1996,721,:1
4Electrochemical capacitor performance of mesoporous carbons obtained by templating technique显示文摘Miranda - Ordieres A J Fuertes A B Centeno T A 2005Carbon2005,43,:1
5Generalization of the influence function method in mining subsidence显示文摘Bello G A Menendez D A Ordieres J B 1996International Journal of Surface Mining Reclamation and Environment1996,10,4:1
6Phase-selective alternating current polarographic assay of methotrexate in human serum显示文摘Artuo J Miranda Ordieres Agustin Costa Garcia Jose M Fernandea Alvarez 1990Anal Chim Acta1990,233,:1
7Deter- mination of dimethylamine in groundwater by liquid chromatography and precolumn derivatization with 9 - fluorenylmethylchloroformate 显示文摘Lopez M R Gonzalez Alvarez M J Miranda Ordieres A J 1996J Chromatogr A1996,721,2:1
8Amperometric detection of ethanol with poly- ( o -phenylenediamine) -modified enzyme electrodes显示文摘CASTANON M J L ORDIERES A J M BLANCO P T 1997Biosens Bioelectron1997,12,6:1
9Modified- RNA Aptamer- Based Sensor for Competitive Impedimetric Assay of Neomycin B 显示文摘de- los- Santos- Alvarez N Lobo- Castafi6n M J Miranda- Ordieres A J 2007Journal of the American Chemical Society2007,129,13:1
10Poly(o-aminophenol)-modified bienzyme carbon paste electrode for the detection of uric acid 显示文摘Miland E Ordieres A J M Tunon Blanco P 1996Talanta1996,43,:1
11SPR sensing of small molecules with modi- fied RNA aptamers : Detection of neomycin B 显示文摘de - los - Santos - Alvarez N Lobo - Castafi6n M J Miranda - Ordieres A J 2009Biosensors and Bioelectronics2009,24,8:1
12Determination of dimethylamine in ground water by liquid chromatography and precolumn derivatization with 9-Fluorenyl methylchloroformate 显示文摘LDPEZ M R ALVAREZ M J G ORDIERES A J M 1996Journal of Chromatography A1996,721,2:1
13Poly(o-aminophenol)-modified bienzyme carbon paste electrode for the detextion of uric acid显示文摘MILAND E ORDIERERS A J M BLANCO P T 1996Talanta1996,43,:1
14Simultaneous adsorptive stripping voltammetric determination of riboflavin and folic acid in multivitamin preparations显示文摘 Miranda Ordieres AJ Costa Garcia A 1993Anal Chim Acta1993,273,12:1
15Phase-selective Alternating Current Polarographic Assay of Methotrexate in Human Serum显示文摘Ordieres A J M García A C Alvarezl J M F 0,,02:1
16Animal models for endoscopic training: do we really need them?显示文摘A. Parra-Blanco N. Gonz??lez R. Gonz??lez J. Ortiz-Fern??ndez-Sordo C. Ordieres 2013Endoscopy2013,,06:1
17SPR sensing of small molecules with modified RNA aptamers:detection of neomycin B显示文摘de-los-Santos-Alvarez N Lobo-Castafi6n MJ Miranda- Ordieres AJ 2009Biosens Bioelectron2009,24,8:1
18Poly(o-aminophenol)-modified bienzyme carbon paste electrode for the detection of the detection of uric acid显示文摘Miland E Ordieres A J M Blanco P T 1996Talanta1996,43,5:1
19Simultaneous adsorptive str ipping voltammetric determination of riboflavin and folic acid in multivitamin p reparations显示文摘 Miranda Ordieres A J 1993Anal Chim Acta1993,273,:1
20Electrechemical capacitor performance of meso- porous carbons obtained by templating technique 显示文摘Miranda - Ordieres A J Fuertes AB Centeno TA a al 2005Carbon2005,43,:1
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