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| 1 | Identification of Differentially Senescing Mutants of Wheat and Impacts on Yield,Biomass and Nitrogen Partitioning显示文摘Increasing photosynthetic capacity by extending canopy longevity during grain filling using slow senescing stay-green genotypes is a possible means to improve yield in wheat. Ethyl methanesulfonate (EMS) mutated wheat lines (Triticum aestivum L. cv. Paragon) were screened for fast and slow canopy senescence to investigate the impact on yield and nitrogen partitioning. Stay-green and fast-senescing lines with similar anthesis dates were characterised in detail. Delayed senescence was only apparent at higher nitrogen supply with low nitrogen supply enhancing the rate of senescence in all lines. In the stay-green line 3 (SG3), on a whole plant basis, tiller and seed number increased whilst thousand grain weight (TGW) decreased; although a greater N uptake was observed in the main tiller, yield was not affected. In fast-senescing line 2 (FS2), yield decreased, principally as a result of decreased TGW. Analysis of N-partitioning in the main stem indicated that although the slow-senescing line had lower biomass and consequently less nitrogen in all plant parts, the proportion of biomass and nitrogen in the flag leaf was greater at anthesis compared to the other lines; this contributed to the grain N and yield of the slow-senescing line at maturity in both the main tiller and in the whole plant. A field trial confirmed senescence patterns of the two lines, and the negative impact on yield for FS2 and a positive impact for SG3 at low N only. The lack of increased yield in the slow-senescing line was likely due to decreased biomass and additionally a possible sink limitation. | Adinda P.Derkx Simon Orford Simon Griffiths M.John Foulkes Malcolm J. Hawkesford | 2012 | Journal of Integrative Plant Biology2012，54，8： | 9 |
| 2 | Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600–Mutant Colorectal Cancer显示文摘 | Corcoran Ryan B. Atreya Chloe E. Falchook Gerald S. Kwak Eunice L. Ryan David P. Bendell Johanna C. Hamid Omid Messersmith Wells A. Daud Adil Kurzrock Razelle Pierobon Mariaelena Sun Peng Cunningham Elizabeth Little Shonda Orford Keith Motwani Monica Bai | 2015 | Journal of Clinical Oncology2015，，34： | 2 |
| 3 | Does clopidogrel increase the degree of platelet inhibition when a plateletglycoprotein Ⅱb/Ⅲa inhibitor has been given? Insight from an optical platelet aggregometry study显示文摘 | Talreja D Lubbe D Orford JL | 2004 | J Throm b Thrombolysis2004，18，1： | 1 |
| 4 | Incidence,correlates,management,and clinical outcome of coronary perforation:analysis of 16298 procedures显示文摘 | Fasseas P Orford JL Panetta CJ | 2004 | Am Heart J2004，147，1： | 1 |
| 5 | Frequency and correlates of coronary stent thrombosis in the modern era: analysis of a single center registry显示文摘 | ORFORD J L LENNON R MELBY S | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 6 | Clinical outcome of pa- tients undergoing non-cardiac surgery in the two months following coronary stenting 显示文摘 | Wilson SH Fasseas P Orford JL | 2003 | J Am Coll Cardiol2003，42，2： | 1 |
| 7 | Exogenous expression of betacatenin regulates contact inhibition, anchorage-independent growth,anoikis, and radiation-induced cell cycle arrest显示文摘 | Orford C C Byers S W | 1999 | J Cell Biol1999，146，4： | 1 |
| 8 | Targeted modification of a human β-globin locus BAC clone using GET recombination and an I-Scel counterselection cassette 显示文摘 | Jamsai D Orford M Nefedov M | 2003 | Genomics2003，82，1： | 1 |
| 9 | Targeted modification of a human beta-globin locus BAC clone using GET Recombination and an I-Scei counterselection cassette显示文摘 | Jamsai D Orford M Nefedov M | 2003 | Genomics2003，82，1： | 1 |
| 10 | Safety and efficacy of aspirin, clopidogrel, and warfarin after coronary stent placement in patients with an indication for anticoagulation 显示文摘 | Orford JL Fasseas P Melby S | 2004 | Am Heart J2004，147，： | 1 |
| 11 | Blunt traumatic aortic transaction: the endovascular experience 显示文摘 | Orford VP Atkinson NR Thomson K | 2003 | Ann Thorac Surg2003，75，1： | 1 |
| 12 | Engineering EGFP reporter constructs into a 200 kb human beta-globin BAC clone using GET Recombination显示文摘 | Orford M Nefedov M Vadolas J | 2000 | Nucl Acids Res2000，28，18： | 1 |
| 13 | Bleomycin therapy for cystic hygroma 显示文摘 | Orford J Barker A Thonell S | 1995 | J Pediatr Surg1995，30，9： | 1 |
| 14 | A comparison of the Framingham and European Society of Cardiology coronary heart disease risk prediction models in the Normative Aging Study显示文摘 | Sesso HD Stedman M | 2002 | Am Heart2002，144，： | 1 |
| 15 | Effect of wateras a diluent on the glass transition behaviour of malto-oligosaccharides, amylose and amylopectin显示文摘 | P D Orford R Parker S G Ring | 1989 | InternationalJournal of Biological Macromolecules1989，11，2： | 1 |
| 16 | Intensive insulin therapy in septic shoek显示文摘 | Orford N R | 2006 | Crit Care Resusc2006，8，1： | 1 |
| 17 | Incidence, correlates, management, and clinical outcome of coronary perforation : analysis of 16298 procedures显示文摘 | Fasseas P Orford JL Panetta CJ | 2004 | Am Heart J2004，147，1： | 1 |
| 18 | Environmental controls on coastal dune formation; Skallingen Spit,Denmark显示文摘 | Aagaard T Orford J Murray A S | 2007 | Geomor- phology2007，83，12： | 1 |
| 19 | Seriene phosphorylation-reguated Ubiquitination and degradation of β-catenin 显示文摘 | Orford K Crocket C Jensen JP | 1997 | J Biol Chem1997，272，24： | 1 |
| 20 | Intensive insulin therapy in septic shock显示文摘 | Orford NR | 2006 | Crit Care Resusc2006，8，： | 1 |
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