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| 1 | Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D显示文摘AIM: To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. METHODS: A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV geno-type was determined by using quantitative real-time polymerase chain reaction and sequence analysis, and tyrosine-methionine-aspartate-aspartate (YMDD) motif mutations were determined using the reverse transcriptase hybridization method. RESULTS: Lamivudine resistance was determined in a total of 25 (10.7%) chronic hepatitis B patients. Eight subjects (4%) had primary resistance to lamivudine, and 17 (53.1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey. CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside nave. | Orhan Yιldιz Bilgehan Aygen Nese Demirtürk Tuna Demirdal Dilara Inan Taner Yιldιrmak Arzu Kantürk Ediz Tütüncü Hepatitis B Study Group | 2011 | World Journal of Gastroenterology2011，17，45： | 3 |
| 2 | Sorption of 2,4 - D on soils显示文摘 | Miray B Orhan Y Ilker Y | 1999 | Water Air Soil Pollut1999，111，14： | 2 |
| 3 | Antibacterial, antifungal, and antiviral activities of some flavonoids显示文摘 | Orhan D D Ozcelik B Ozgen S | 2010 | Microbiological Research2010，165，6： | 1 |
| 4 | Comparative Fatty Acid Analysis of Telekia Speciosa 显示文摘 | Orhan I Sener B | 2003 | Chemistry of Natural Compounds2003，，3： | 1 |
| 5 | Is deep vein thrombosis a good proxy for pulmonary embolus显示文摘 | Javad P Christina L J Orhan B | 2010 | The Journal of Arthroplasty2010，15，6： | 1 |
| 6 | Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants 显示文摘 | Orhan I Sener B Choudhary M I | 2004 | Journal of Ethnopharmacology2004，91，： | 1 |
| 7 | computerized ionospheric tomography with the IRI model 显示文摘 | Orhan Arikan Feza Arikan Cemil B Erol | 2007 | Advances in Space Research2007，39，： | 1 |
| 8 | High dose eabergolinein management of ovarian hyperstimulation syndrome 显示文摘 | Ata B Seyhan A Orhaner S | 2009 | Fertil Steril2009，5，： | 1 |
| 9 | Malignant tumors metastatic to the ovarics显示文摘 | Ali A Selcuk T Orhan B | 1995 | J Surg Oncol1995，60，： | 1 |
| 10 | Larynx osteosarcoma: case report 显示文摘 | ARSLAN M ORHAN KIZILKAYA H YAL(2IN B | 2008 | J BUON2008，13，： | 1 |
| 11 | An unusual cause of acute renal failure:renal lymphoma显示文摘 | Yalcin B Orhan D etal | 2004 | Pediatr nephrol2004，19，8： | 1 |
| 12 | Radical quenching activity, ferric - reducing antioxidant power, and ferrous ion -chelating capacity of 16 Ballota species and their total phenol and ilavonoid contents显示文摘 | Erdngan- Orhan I Sever- Yilmaz B Altun M L | 2010 | Journal of Medicinal Food2010，13，6： | 1 |
| 13 | Cone beam CT evalu- ation of maxillary sinus septa prevalence, height, location and mor- phology in children and an adult population显示文摘 | Orhan K Kusakci Seker B Aksoy S | 2013 | Med Princ Pract2013，22，1： | 1 |
| 14 | Studying cytokines of T helper cells in the kidney disease of IgA vasculitis (henoch-schonlein purpura) 显示文摘 | Giilhan B Orhan D Kale G | 2015 | Pediatr Nephrol2015，30，8： | 1 |
| 15 | Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plant显示文摘 | ORHAN I SENER B CHOUDHARY M I | 2004 | J Ethnopharmacol2004，91，1： | 1 |
| 16 | Antimalarial activity screening of some alkaloids and the plant extracts from amaryllidaceae显示文摘 | SENER B ORHAN I SATAYAVIVAD J | 2003 | Phytother Res2003，17，10： | 1 |
| 17 | Internal modification of poly (dimethylsiloxane) microchannels with a borosilicate glass coating 显示文摘 | Orhan J B Parashar V K Flueckiger J | 2008 | Langmuir2008，24，16： | 1 |
| 18 | Utilization ofkraft pulp production residues in clay brickproduction显示文摘 | ISMAIL D SERHAT B M ORHAN M | 2005 | Building and Environment2005，40，11： | 1 |
| 19 | Erythropoietin against cispl- atin induced peripheral neurotoxicity in rats 显示文摘 | Orhan B Yalcin S Nurlu G | 2004 | Med Oncal2004，21，2： | 1 |
| 20 | Enhancement of biodegradability of disposable polyethylene in controlled biological soil显示文摘 | Yüksel Orhan Hanife Büyükgüngor | 2000 | International Biodeterioration & Biodegradation2000，45，： | 1 |
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