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| 1 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013，19，35： | 26 |
| 2 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 3 | Stroke subtype classification to mechanism-specific and undetermined categories by TOAST,ASCO,and Causative Classification System显示文摘 | Michael M Caroline AD Orla C | 2010 | Stroke2010，41，8： | 1 |
| 4 | Mechanisms of obesity in- duced inflammation and insulin resistance: insights into the e- merging role of nutritional strategies 显示文摘 | Maeve A McAMle Orla M | 2013 | Front Endocrinol (Lausanne)2013，10，4： | 1 |
| 5 | Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms显示文摘 | ORLA M BISERKA M J TOHN P | 2003 | Steroids2003，68，7： | 1 |
| 6 | Irritable bowel syndrome; update on pathophysiology and management 显示文摘 | Eamonn M Quigley M Orla F | 2012 | Turk J Gas troenterol2012，23，4： | 1 |
| 7 | Determination of toxic cyclic heptapeptides by liquid chromatography with detection using ultra-violet, protein phosphatase assay and tandem mass spectrometry 显示文摘 | Ortea Paloma Muniz Allis Orla Healy Brendan M | 2004 | Chemosphere2004，55，10： | 1 |
| 8 | Stroke subtype classification to mechanism--Specific and undetermined categories by TOAST,A-S-C-O,and causative classification system显示文摘 | Michael M Caroline AD Orla C | 2010 | Stroke2010，41，8： | 1 |
| 9 | Further evidence of differcences in substance use and dependence between Australia and the United States显示文摘 | Orla M Maree T Tim S | 2009 | Drug Alcohol Depend2009，100，： | 1 |
| 10 | A comprehensive study of metal distribution in three main classes of seaweed 显示文摘 | Siobhan R Peter M Orla O | 2012 | Environmental Pollution2012，167，： | 1 |
| 11 | Reproductive tissue selective actions of progesterone receptors 显示文摘 | Biserka M J Orla M | 2004 | Reprod2004，128，： | 1 |
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