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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | Progression to persistent lymphocytosis and tumor development in bovine leukemia virus (BLV)-infected cattle correlate s with impaired proliferation of CD4+ T cells in response to gag- and env-enc oded BLV proteins显示文摘 | Splitter G A | 1996 | J Virol1996，70，11： | 1 |
| 3 | Gas-sensitive properties of thin and thick film sensors based on Fe2O3-SnO2 nanocomposites显示文摘 | KOTSIKAU D IVANOVSKAYA M ORLIK D | 2004 | Sensors and Actuators B2004，101，： | 1 |
| 4 | Unitary reflection groups and cohomology显示文摘 | Peter Orlik Louis Solomon | 1980 | Inventiones Mathematicae1980，，1： | 1 |
| 5 | Combinatorics and topology of complements of hyperplanes显示文摘 | Peter Orlik Louis Solomon | 1980 | Inventiones Mathematicae1980，，2： | 1 |
| 6 | UWB systems for wireless sensor networks显示文摘 | ZHANG J Y ORLIK P V SAHINOGLU Z | 2009 | Proceedings of the IEEE2009，97，2： | 1 |
| 7 | The role of adipokines and insulin resistance in the pathogenesis of nonalco- holic fatty liver disease 显示文摘 | Orlik B Handzlik G Olszanecka-Glinianowicz M | 2010 | Postepy Hig Med Dosw ( online)2010，64，： | 1 |
| 8 | An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia显示文摘 | Benet-Pagès A Orlik P Strom TM | 2005 | Hum Mol Genet2005，14，3： | 1 |
| 9 | The role of adipokines and insulin resistance in the pathogenesis of nonal- coholic fatty liver disease显示文摘 | Orlik B Handzlik G Olszanecka-Glinianowicz M | 2010 | Postepy Hig Med Dosw2010，64，： | 1 |
| 10 | Hypersonic boundary layer tran sition forced by wall injection: A numerical study显示文摘 | ORLIK E FEDIOUN I | 2014 | Journal of Spacecraft and Rockets2014，51，4： | 1 |
| 11 | TOA estimation for IR - UWB systems with different transceiver types 显示文摘 | Guvenc I Sahinoglu Z Orlik P V | 2006 | MicrowaveTheory and Techniques IEEE Transactions on2006，54，4： | 1 |
| 12 | TOA Estimation for IR-UWB Systems with Different Transceiver Types显示文摘 | GUVENC I SAHINOGLU Z ORLIK P V | 2006 | IEEE Transactions on Wireless Communications2006，54，4： | 1 |
| 13 | UWB Systems for wireless sensor networks显示文摘 | ZHANG J ORLIK P | 2009 | Proceedings of the IEEE2009，97，2： | 1 |
| 14 | TOA estimation for IR-UWB systems with different transceiver types显示文摘 | GUVENC I SAHINOGLU Z ORLIK P | 2006 | IEEE Trans Microwave Theory and Techniques2006，54，4： | 1 |
| 15 | The role of adipokines and insulin resistance in the pathogene- sis of nonalcoholic fatty liver disease显示文摘 | Orlik B Handzlik G Olszanecka-Glinianowicz M | 2010 | Postepy HigMed Dosw (Online)2010，64，： | 1 |
| 16 | Statistics-based ICI mitigation in OFDM over high-mobility channels with line-of-sight components显示文摘 | MA J ORLIK P ZHANG J Y LI Y | 2011 | IEEE Trans on Wireless Communications2011，10，11： | 1 |
| 17 | Gauss–Man i n Conne ction s for Arrangements, I E igenvalues显示文摘 | Daniel C. Cohen Peter Orlik | 2003 | Compositio Mathematica2003，，3： | 1 |
| 18 | UWB systems for wireless sensor networks 显示文摘 | ZHANG J Z ORLIK P V SAHINOGLU Z | 2009 | Proceedings of the IEEE2009，97，2： | 1 |
| 19 | Multiderivations of coxeter arrangements显示文摘 | Orlik P | 2002 | Invention Mathematics2002，148，： | 1 |
| 20 | Hybrid ultrawideband modulations compatible for both coherent and transmit-reference re- ceivers显示文摘 | ZHAO S W ORLIK P MOLISCH A F | 2007 | IEEE Trans Wireless Communications2007，6，7： | 1 |
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