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	题名	作者	年代	出处	被引量
1	Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments.	Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen	2019	World Journal of Gastroenterology2019，25，33：	3
2	Autoimmune thyroiditisassociated with polycystic ovary syndrome:Comments about 25cases显示文摘	Gudovan E Diaconescu C Oros S	2008	Acta Endocrinologica(Buc)2008，4，2：	1
3	Biological activity and environmental impact of anionic surfactants显示文摘	CSERH(A)TI T FORG(A)CS E OROS G	2002	Environment International2002，28，5：	1
4	Removal of Synthetic Dyes From Wastewaters : A Review 显示文摘	FORGACS E CSERHATI T OROS G	2004	Environment International2004，30，7：	1
5	Removal of synthetic dyes from wastewaters:a review显示文摘	FORGACS E CSERHATI T OROS G	2004	Environment International2004，30，7：	1
6	Organiccarbon and nitrogen in soils of semiarid Argentina显示文摘	Mendez M J Oro L D Panebianeo J E	2006	Joumal of Soil and Water Conservation2006，61，4：	1
7	Removal of synthetic dyes from wastewaters: a review 显示文摘	Forgaes E Cserhati T Oros G	2004	Environment International2004，30，：	1
8	Removal of synthetic dyes from wastewaters: a review 显示文摘	Forgacs E Cserhati T Oros G	2004	Environment International2004，30，：	1
9	Degradation of the soil surface roughness by rainfall in two loess soils显示文摘	De Oro L A and Buschiazzo D E	2011	Geoderma2011，164，1：	1
10	Stratification analysis in packed bed thermal energy storage systems显示文摘	ORO E CASTELL A	2013	Applied Energy2013，109，：	1
11	Identification of a nuclear receptor that is activated by farnesol metabolites显示文摘	Barry M Forman Elizabeth Goode Jasmine Chen Anthony E Oro David J Bradley Thomas Perlmann Daniel J Noonan Leo T Burka Trevor McMorris William W Lamph Ronald M Evans Cary Weinberger	1995	Cell1995，，5：	1
12	Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop 显示文摘	Woo W 'M Zhen H H Oro A E	2012	Genes Dev2012，26，11：	1
13	Removal of synthetic dyes from wastewaters: a review 显示文摘	Forgacs E Cserhati T Oros G	2004	Environment International2004，30，7：	1
14	Stratification analysis in packed bed thermal energy storage systems 显示文摘	Oro E Castell A Chiu J	2013	Applied Energy2013，109，1：	1
15	An improved in vitro technique for isolated microspore culture of barley显示文摘	Kasha K J Simion E Oro R	2001	Euphytica2001，，120：	1
16	Hair cycle regulation of Hedgehog signal reception 显示文摘	ANTHONY E ORO KAY HIGGINSL	2003	Developmental Biology2003，，255：	1
17	Removal of synthetic dyes from wastewater显示文摘	Forgacs E Cserhati T Oros G	2004	Emviroment International2004，30，7：	1
18	Apoptosis and free radicals显示文摘	Stoian I Oros A Moldoveanu E	1996	Biochem Mol Med1996，59，：	1
19	Removal of synthetic dyes from wastewaters:A review显示文摘	Forgacs E Cserháti T Oros G	2004	Environment International2004，30，7：	1
20	Hydrocarbons of geochemical significance in microscopic algae 显示文摘	Gelpi E Schneider H Mann J Oro J	1970	Phytochemistry1970，9，：	1

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