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| 1 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 2 | 适合水稻悬浮培养细胞蛋白质组分析的双向电泳技术显示文摘水稻是研究植物蛋白质组学的一个重要试材,从蛋白质的提取,裂解缓冲液的成份和浓度,第一向聚焦的条件,蛋白上样量和二向胶的选择方面,对水稻悬浮培养细胞的双向电泳条件进行了比较和优化。结果表明,采用甲醇/氯仿沉淀蛋白,裂解缓冲液中加入0.5%的两性电解质、并加入盐桥,17cm的胶条、850μg的上样量可达到较好的等电聚焦效果;8%-16%梯度胶分离蛋白较为适宜。 | 刘悦萍 杨爱珍 郭蓓 余萍 Horvath Gabor V Gyula Orosz | 2010 | 生物技术通报2010，26，11： | 2 |
| 3 | Narrative Structures in Culture 显示文摘 | | 2000 | Semiotica2000，，： | 1 |
| 4 | Rabbit respiratory system:clini-cal anatomy,physiology and disease显示文摘 | Johnson-Delaney C A Orosz S E | | 0，，： | 1 |
| 5 | Clinical relevance of anti-HLA antibodies pre and post transplant显示文摘 | Kerman R H Orosz CG Lorber MI | 1997 | Am J Med Sci1997，313，： | 1 |
| 6 | Healing of esophageal anastomoses performed with the biofragmentable anastomosis ring versus the end-to-end anastomosis stapler: comparative experimental study in dogs 显示文摘 | Kovacs T Koves I Orosz Z | 2003 | World J Surg2003，27，4： | 1 |
| 7 | Preoperative status and risk of complications in patients with hip fracture显示文摘 | McLaughlin MA Orosz GM Magaziner J | 2006 | J Gen Intern Med2006，21，3： | 1 |
| 8 | Healing of esophageal anastomoses per-formed with the biofragmentable anastomosis ring versus the end-to-end anastomosis stapler:comparative experimental study in dogs显示文摘 | Kovacs T Koves I Orosz Z | 2003 | World J Surg2003，27，4： | 1 |
| 9 | Delay effects in shimmy dynamics of wheels with stretched string-like tyres显示文摘 | D6nes Taktcs Gcbor Orosz G6bor Stp(m | 2009 | European Journal of Mechanics2009，28，3： | 1 |
| 10 | Application of gas separation to recover biohydrogen produced by Thiocapsa roseopersicina显示文摘 | Orosz T Balint B | 2004 | Desalination2004，163，： | 1 |
| 11 | Promotion of experiment liver metastasis by tumor necrosis factor显示文摘 | OROSZ P KRUGER A HUBBE M | 1995 | Int J Cancer1995，60，6： | 1 |
| 12 | Theta burst TMS increas- es cerebral blood flow in the primary motor cortex during motor performance as assessed by arterial spin labeling (ASL) 显示文摘 | Orosz A Jann K Wirth M | 2012 | Neuroimage2012，61，3： | 1 |
| 13 | As-sessment of cerebrovascular reserve capacity in asymptomaticand symptomatic hemodynamically significant carotid stenosesand occlusions 显示文摘 | Laszlo Orosz Bela F ii lesdi Arjan Hoksbergen | 2002 | Surg Neurol2002，57，5： | 1 |
| 14 | Can graft endothelial cells initiate a host anti-graft immune response?显示文摘 | Pober JS Orosz CG Rose ML | 1996 | Transplantation1996，61，3： | 1 |
| 15 | Dystrophic epidermolysis bullosa complicated by cutaneous squamous cell carcinoma and pulmonary and renal amyloidosis显示文摘 | Csikos M Orosz Z Bottlik G | 2003 | Clin Exp Dermatol2003，28，2： | 1 |
| 16 | Clinical Relevance of Anti-HLA Antibodies Pre and Post Transplant显示文摘 | Ronald H. Kerman Charles G. Orosz Marc I. Lorber | 1997 | The American Journal of the Medical Sciences1997，，5： | 1 |
| 17 | Predictive validity of end- points used in electrophysiological modelling of migraine in the tri- geminovascular system显示文摘 | Farkas B Kardos P Orosz S | 2015 | Brain Res2015，1625，： | 1 |
| 18 | Long-term storage of wet CGF: Et~uent, optimal density, fermentation and aerobic stability显示文摘 | Orosz S Kapas S | 2010 | Forage Conserva- tion2010，，3： | 1 |
| 19 | Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries显示文摘 | Ungvari Z Orosz Z Labinskyy N | | 0，，01： | 1 |
| 20 | Association of timing of surgery for hip fracture and patient outcomes 显示文摘 | Orosz GM Magaziner J Hannan EL | 2004 | JAMA2004，291，14： | 1 |
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