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| 1 | On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook显示文摘The demand for biomaterials that promote the repair,replacement,or restoration of hard and soft tissues continues to grow as the population ages.Traditionally,smart biomaterials have been thought as those that respond to stimuli.However,the continuous evolution of the field warrants a fresh look at the concept of smartness of biomaterials.This review presents a redefinition of the term“Smart Biomaterial”and discusses recent advances in and applications of smart biomaterials for hard tissue restoration and regeneration.To clarify the use of the term“smart biomaterials”,we propose four degrees of smartness according to the level of interaction of the biomaterials with the bio-environment and the biological/cellular responses they elicit,defining these materials as inert,active,responsive,and autonomous.Then,we present an up-to-date survey of applications of smart biomaterials for hard tissues,based on the materials’responses(external and internal stimuli)and their use as immune-modulatory biomaterials.Finally,we discuss the limitations and obstacles to the translation from basic research(bench)to clinical utilization that is required for the development of clinically relevant applications of these technologies. | Carolina Montoya Yu Du Anthony L.Gianforcaro Santiago Orrego Maobin Yang Peter I.Lelkes | 2021 | Bone Research2021，9，2： | 7 |
| 2 | Phylogenetic compo sition of bacteriop lank ton from two California estuaries compared by denaturing gradient gel electropho resis of 16S rDNA fragments显示文摘 | Murray A E Hollibaugh J T Orrego C | 1996 | Applied and Environmental Microbiology1996，62，7： | 1 |
| 3 | Effect of freezing rate on quality parameter of freeze dried soursop fruit plup 显示文摘 | Ceballors A M Giraldo G I Orrego G E | 2012 | Journal of Food Engineering2012，111，2： | 1 |
| 4 | Phylogenetic composition of bacterioplankton from two California estuaries compared bydenaturing gradient gel electrophoresis of 16S rDNA fragments显示文摘 | Murray A E Hollibaugh J T Orrego C | 1996 | Appl Environ Microbiol1996，62，： | 1 |
| 5 | Thrombus aspiration before standardprimary angioplasty improves myocardial reperfusion in acute myocardialinfarction:The DEAR-MI(De thrombosis to Enhance Acute Reperfusionin Myocardial Infarction)Study显示文摘 | Orrego PS Colombo P Bigi R | 2006 | J Am Coll Cardiol2006，48，8： | 1 |
| 6 | Genetic variation and phylogeog- raphy of central Asian and other house mice,including a major new rtrito- chondrial lineage in Yemen 显示文摘 | PRAGER E M ORREGO C SAGE R D | 1998 | Genetics1998，150，2： | 1 |
| 7 | Phylogenetic composition of bacterio lank ton from two California estuaries compared by denaturing gradient gel electrophoresis of 16S rDNA fragments显示文摘 | Murray A E Hollibaugh J T Orrego C | 1996 | Appllied Environmetnal Microbiology1996，62，7： | 1 |
| 8 | Phylogenetic composition of bacterioplankton from two California estuaries compared by denaturing gradient gel electrophoresis of 16S rDNA fragments 显示文摘 | Murray A E Ho llibaugh J T Orrego C | 1996 | Appl Environ Microbiol1996，62，7： | 1 |
| 9 | Cellular evidence of re- verse cardiac remodeling induced by cardiac resynchronization therapy 显示文摘 | Orrego CM Nasir N Oliveira GH | 2011 | Congest Heart Fail2011，17，3： | 1 |
| 10 | Polygenetic compositions of bacterioplankton fromtwo California estuaries compared by denaturing gradient gel electrophoresis of 16S rDNA fragments 显示文摘 | Murray A E Honihaugh J T Orrego C | 1996 | Appl Environ Microbiol1996，62，7： | 1 |
| 11 | Inflammation a potential target for therapeutic interven- tion in heart failure显示文摘 | Orrego CM | 2009 | Methodist Debakey Cardiovasc J2009，5，3： | 1 |
| 12 | Phylogenetic composition of bacterioplankton from two California estuaries compared by denaturing gradient gel eletrophoresis of 16S rDNA fragments显示文摘 | Murray A E Hollibaugh J T Orrego C | 1996 | Applied and Environmental Microbiology1996，62，7： | 1 |
| 13 | Distal protion in native coronary arteries during primary angioplasty in acute myocardial infarction:single-center experience显示文摘 | Orrego PS Delgado A Piccalo G | 2003 | Catheter Cardiovasc Interv2003，60，2： | 1 |
| 14 | Phylogenetie composition of baeterioplankton from two California estuaries compared by denatu- ring gradient gel electrophoresis of 16SrDNA fragments 显示文摘 | Murray A E Hollibaugh J T Orrego C | 1996 | Applied Environmental Microbiology1996，62，： | 1 |
| 15 | Thrombus Aspiration Before Standard Primary Angioplasty Improves Myocardial Reperfusion in Acute Myocardial Infarction:The DEAR MI(Dethrombosis to En-hance Acute Reperfusion in Myocardial Infarction)Study显示文摘 | Orrego PS Colombo P Bigi R | | 0，，08： | 1 |
| 16 | Phylogenetic composition of bacteri-oplankton from two California estuaries compared by denaturing gradient gel electrophoresis of 16S rDNA fragments 显示文摘 | Murray AE Hollibaugh JT Orrego C | 1996 | Appl Environ Microbiol1996，62，7： | 1 |
| 17 | Phylogeneticcompositions of bacterioplankton from two California estuaries compared by denaturing gradient gel electrophoresis of 16S rDNA fragments 显示文摘 | Murray A E Hollibaugh J T Orrego C | 1996 | Applied and Environmental Microbiology1996，62，7： | 1 |
| 18 | Arbitrationina New Intemational Alternative Dispute Resolution System显示文摘 | Francisco Orrego Vicuna | 2002 | Dispute Resolution Journal(New York)May-Jul2002，，2： | 1 |
| 19 | Thrombus AspirationBeforeStandard Primary Angioplasty Improves MyocardialReperfusion in Acute Myocardial Infarction:The DEARMI(Dethrombosis to EnhanceAcute Reperfusion in Myo-cardial Infarction)Study显示文摘 | Orrego PS Colombo P Bigi R | 2006 | J Am Coll Cardiol2006，48，8： | 1 |
| 20 | Cytokines and acute heart failure 显示文摘 | Chen D As sad - Kottner C Orrego C | 2008 | Crit Care IVied2008，36，1： | 1 |
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