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| 1 | Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer显示文摘AIM:To investigate feasibility,morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer.METHODS:Patients suffering from locally-advanced(T3-4 any N M0 or any T N1-3 M0)gastric carcinoma,staged with endoscopic ultrasound,bone scan,computed tomography,and laparoscopy,were assigned to receive four 21 d/cycles of TCF(docetaxel 75 mg/m 2 day 1,cisplatin 75 mg/m 2 day 1,and fluorouracil 300 mg/m 2 per day for days 1-14),either before(Arm A)or after(Arm B)gastrectomy.Operative morbidity,overall mortality,and severe adverse events were compared by intention-to-treat analysis.RESULTS:From November 1999 to November 2005,70 patients were treated.After preoperative TCF(Arm A),thirty-two(94%)resections were performed,85% of which were R0.Pathological response was complete in 4 patients(11.7%),and partial in 18(55%).No surgical mortality and 28.5%morbidity rate were observed,similar to those of immediate surgery arm(P= 0.86).Serious chemotherapy adverse events tended to be more frequent in arm B(23%vs 11%,P=0.07),with a single death per arm.CONCLUSION:Surgery following docetaxel-based chemotherapy was safe and with similar morbidity to immediate surgery in patients with locally-advanced resectable gastric carcinoma. | Roberto Biffi Nicola Fazio Fabrizio Luca Antonio Chiappa Bruno Andreoni Maria Giulia Zampino Arnaud Roth Jan Christian Schuller Giancarla Fiori Franco Orsi Guido Bonomo Cristiano Crosta Olivier Huber | 2010 | World Journal of Gastroenterology2010，16，7： | 43 |
| 2 | Hepatitis C virus in the new era:Perspectives in epidemiology,prevention,diagnostics and predictors of response to therapy显示文摘Despite the great successes achieved in the fields of virology and diagnostics,several difficulties affect improvements in hepatitis C virus(HCV)infection control and eradication in the new era.New HCV infections still occur,especially in some of the poorest regions of the world,where HCV is endemic and long-term sequelae have a growing economic and health burden.An HCV vaccine is still no available,despite years of researches and discoveries about the natural history of infection and host-virus interactions:several HCV vaccine candidates have been developed in the last years,targeting different HCV antigens or using alternative delivery systems,but viral variability and adaption ability constitute major challenges for vaccine development.Many new antiviral drugs for HCV therapy are in preclinical or early clinical development,but different limitations affect treatment validity.Treatment predictors are important tools,as they provide some guidance for the management of therapy in patients with chronic HCV infection:in particular,the role of host genomics in HCV infection outcomes in the new era of direct-acting antivirals may evolve for new therapeutic targets,representing a chance for modulated and personalized treatment management,when also very potent therapies will be available.In the present review we discuss the most recent data about HCV epidemiology,the new perspectives for the prevention of HCV infection and the most recent evidence regarding HCV diagnosis,therapy and predictors of response to it. | Filippo Ansaldi Andrea Orsi Laura Sticchi Bianca Bruzzone Giancarlo Icardi | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 3 | Clinical implications of diabetes in chronic liver disease:Diagnosis,outcomes and management,current and future perspectives显示文摘Diabetes mellitus(DM)is common in liver cirrhosis(LC).The pathophysiological association is bidirectional.DM is a risk factor of LC and LC is a diabetogenic condition.In the recent years,research on different aspects of the association DM and LC has been intensified.Nevertheless,it has been insufficient and still exist many gaps.The aims of this review are:(1)To discuss the latest understandings of the association of DM and LC in order to identify the strategies of early diagnosis;(2)To evaluate the impact of DM on outcomes of LC patients;and(3)To select the most adequate management benefiting the two conditions.Literature searches were conducted using Pub Med,Ovid and Scopus engines for DM and LC,diagnosis,outcomes and management.The authors also provided insight from their own published experience.Based on the published studies,two types of DM associated with LC have emerged:Type 2 DM(T2 DM)and hepatogenous diabetes(HD).High-quality evidences have determined that T2 DM or HD significantly increase complications and death pre and post-liver transplantation.HD has been poorly studied and has not been recognized as a complication of LC.The management of DM in LC patients continues to be difficult and should be based on drug pharmacokinetics and the degree of liver failure.In conclusion,the clinical impact of DM in outcomes of LC patients has been the most studied item recently.Nevertheless many gaps still exist particularly in the management.These most important gaps were highlighted in order to propose future lines for research. | Diego García-Compeán Emanuela Orsi Ramesh Kumar Felix Gundling Tsutomu Nishida Jesús Zacarías Villarreal-Pérez Ángel N Del Cueto-Aguilera JoséA González-González Giuseppe Pugliese | 2022 | World Journal of Gastroenterology2022，28，8： | 4 |
| 4 | Assessing Ebola-related web search behaviour: insights and implications from an analytical study of Google Trends-based query volumes显示文摘Background:The 2014 Ebola epidemic in West Africa has attracted public interest worldwide,leading to millions of Ebola-related Internet searches being performed during the period of the epidemic.This study aimed to evaluate and interpret Google search queries for terms related to the Ebola outbreak both at the global level and in all countries where primary cases of Ebola occurred.The study also endeavoured to look at the correlation between the number of overall and weekly web searches and the number of overall and weekly new cases of Ebola.Methods:Google Trends(GT)was used to explore Internet activity related to Ebola.The study period was from 29 December 2013 to 14 June 2015.Pearson’s correlation was performed to correlate Ebola-related relative search volumes(RSVs)with the number of weekly and overall Ebola cases.Multivariate regression was performed using Ebola-related RSV as a dependent variable,and the overall number of Ebola cases and the Human Development Index were used as predictor variables.Results:The greatest RSV was registered in the three West African countries mainly affected by the Ebola epidemic.The queries varied in the different countries.Both quantitative and qualitative differences between the affected African countries and other Western countries with primary cases were noted,in relation to the different flux volumes and different time courses.In the affected African countries,web query search volumes were mostly concentrated in the capital areas.However,in Western countries,web queries were uniformly distributed over the national territory.In terms of the three countries mainly affected by the Ebola epidemic,the correlation between the number of new weekly cases of Ebola and the weekly GT index varied from weak to moderate.The correlation between the number of Ebola cases registered in all countries during the study period and the GT index was very high.Conclusion:Google Trends showed a coarse-grained nature,strongly correlating with global epidemiological data,but was weaker at country level,as it was prone to distortions induced by unbalanced media coverage and the digital divide.Global and local health agencies could usefully exploit GT data to identify disease-related information needs and plan proper communication strategies,particularly in the case of health-threatening events. | Cristiano Alicino Nicola Luigi Bragazzi Valeria Faccio Daniela Amicizia Donatella Panatto Roberto Gasparini Giancarlo Icardi Andrea Orsi | 2015 | Infectious Diseases of Poverty2015，4，1： | 3 |
| 5 | Size, trend, and policy implications of the underground economy显示文摘 | Renzo Orsi Davide Raggi Francesco Turino | 2012 | Review of Economic Dynamics2012，，： | 2 |
| 6 | Heavily calcified gastrointestinal stromal tumors:Pathophysiology and implications of a rare clinicopathologic entity显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls. Herein, we report a gastric GIST with the unusual presentation of prominent calcifications that was identified incidentally on imaging during a post-trauma diagnostic work-up. The patient underwent laparoscopic surgery with a radical resection of the mass, which was subsequently characterized by histological analysis as spindle-shaped tumor cells, positive for CD117/c-KIT, CD34 and DOG1, and with calcified areas. Given the intermediate risk of recurrence, no adjuvant therapy was recommended andthe patient underwent regular follow-up for 22 mo, with no evidence of relapse. Our case can be considered of interest because of the rarity of clinical presentation and the uniquely large size of the GIST at diagnosis(longest diameter exceeding 9 cm). In closing, we discuss the pathophysiology and clinical implications of calcifications in GISTs by reviewing the most up-to-date relevant literature. | Massimiliano Salati Giulia Orsi Luca Reggiani Bonetti Fabrizio Di Benedetto Giuseppe Longo Stefano Cascinu | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 2 |
| 7 | Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE)显示文摘 | Alicia Amigou Jérémie Rudant Laurent Orsi Stéphanie Goujon-Bellec Guy Leverger André Baruchel Yves Bertrand Brigitte Nelken Geneviève Plat Gérard Michel Stéphanie Haouy Pascal Chastagner Stéphane Ducassou Xavier Rialland Denis Hémon Jacqueline Clavel | 2012 | Cancer Causes & Control2012，，8： | 2 |
| 8 | ROV Based Underwater Blurred Image Restoration显示文摘In this paper, we present a method of ROV based image processing to restore underwater blurry images from the theory of light and image transmission in the sea. Computer is used to simulate the maximum detection range of the ROV under different water body conditions. The receiving irradiance of the video camera at different detection ranges is also calculated. The ROV’s detection performance under different water body conditions is given by simulation. We restore the underwater blurry images using the Wiener filter based on the simulation. The Wiener filter is shown to be a simple useful method for underwater image restoration in the ROV underwater experiments. We also present examples of restored images of an underwater standard target taken by the video camera in these experiments. | LIU Zhishen *, DING Tianfu, WANG GangOcean Remote Sensing Institute (ORSI), Ocean Unversity of China, Qingdao 266003, P..R.China | 2003 | Journal of Ocean University of Qingdao2003，2，1： | 2 |
| 9 | The use of metformin for women with PCOS undergoing IVF treatment 显示文摘 | Tang T Glanville J Orsi N | 2006 | Hum Reprod2006，21，6： | 1 |
| 10 | Amercian college of radiology guideline for breast cancer screening 显示文摘 | Feig SA D'Orsi CJ Hendrick KE | 1998 | AJR1998，171，1： | 1 |
| 11 | Transgingival lag- screw osteosynthesis of alveolar process fracture显示文摘 | Nyarady Z Orsi E Nagy K | 2010 | Int J oral Maxillofac Surg2010，39，8： | 1 |
| 12 | BI-RADS decoded: detailed guidance on potentially confusing issues 显示文摘 | D'Orsi CJ Newel1 MS | 2007 | Radiol Clin North Am2007，45，5： | 1 |
| 13 | Human menopausal and pregnant mare serum gonadotrophins in murine superovulation regimens for transgenic applications显示文摘 | Brooke DA Orsi NM Ainscough JF | 2007 | Theriogenology2007，67，8： | 1 |
| 14 | Pediatric obesity epidemiology 显示文摘 | Orsi CM Hale DE Lynch ]L | 2011 | Current Opinion in Endocrinology Diabetes &Obesity2011，18，： | 1 |
| 15 | Hospital-acquired infection surveillance in a neonatal intensive care unit显示文摘 | Orsi GB dIEttorre G Panero A | 2009 | Am J Infect Control2009，37，3： | 1 |
| 16 | Does biotech reflect a new science-based innovation regime?显示文摘 | Coriat B Orsi F Weinstein O | 2003 | Industry and Innovation2003，10，3： | 1 |
| 17 | Application of antimi- erobial-producing lactic acid bacteria to control patho- gens in ready-to-use vegetables显示文摘 | Vescovo M Torriani S Orsi C | 1996 | Journal of Applied Bacterialogy1996，81，： | 1 |
| 18 | The antimicrobial activity of lactoferrin: current status and perspectives显示文摘 | Orsi N | 2004 | Biometals2004，17，3： | 1 |
| 19 | Immunomodulatory action of propolis on macrophage activation 显示文摘 | Orsi R O Funari S R C Soares A M V C | 2000 | J Venom AnimToxins2000，6，： | 1 |
| 20 | Best choice of central venous insertion site for the prevention of catheter-related complications in adult patients who need cancer therapy:a randomized trial显示文摘 | Biffi R Orsi F Pozzi S | 2009 | Ann Oncol2009，20，5： | 1 |
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