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| 1 | Comparison of endoscopic stenting for malignant biliary obstruction: A single-center study显示文摘AIM: To evaluate the efficacy and safety of single-step endoscopic placement of self-expandable metallic stents(SEMS) for treatment of obstructive jaundice.METHODS: A retrospective study was performed among 90 patients who underwent transpapillary biliary metallic stent placement for malignant biliary obstruction(MBO) between April 2005 and October 2012. The diagnosis of primary disease and MBO was based on abdominal ultrasound, computed tomography, magnetic resonance imaging, endoscopic ultrasound, endoscopic retrograde cholangiopancreatography with brush cytology, biopsy, and/or a combination of these modalities. The type of SEMS(covered or non-covered, 8 mm or 10 mm in diameter) was determined by the endoscopist. Ninety patients were divided into two groups: group 1(49 patients) who underwent a singlestep SEMS placement and group 2(41 patients) who underwent a two-step SEMS placement. The technical success rate, complication rate, stent patency, and patient survival rate were compared between the groups. In addition, to identify the clinical prognostic factors associated with patient survival, the following variables were evaluated in Cox-regression analysis: gender, age, etiology of MBO(pancreatic cancer or nonpancreatic cancer), clinical stage(Ⅳb; with distant metastases or Ⅳa >; without distant metastases), chemotherapy(with or without), patency of the stent, and the use of single-step or two-step SEMS. RESULTS: Immediate technical success was achieved in 93.9%(46/49) in group 1 and in 95.1%(39/41) in group 2, with no significant difference(P = 1.0). Similarly, there was no difference in the complication rates between the groups(group 1, 4.1% and group 2, 4.9%; P = 0.62). Stent failure was observed in 10 cases in group 1(20.4%) and in 16 cases in group 2(39.0%). The patency of stent and patient survival revealed no difference between the two groups with Kaplan-Meier analysis, with a mean patency of 111 ± 17 d in group 1 and 137 ± 19 d in group 2(P = 0.91), and a mean survival of 178 ± 35 d in group 1 and 222 ± 23 d in group 2(P = 0.57). On the contrary, the number of days of hospitalization associated with first-time SEMS placement in group 1 was shorter when compared with that number in group 2(28 vs 39 d; P < 0.05). Multivariate analysis revealed that a clinical stage of Ⅳa >(P = 0.0055), chemotherapy(P = 0.0048), and no patency of the stent(P = 0.011) were independent prognostic factors associated with patient survival.CONCLUSION: Our results showed that single-step endoscopic metal stent placement was safe and effective for treating obstructive jaundice secondary to various inoperable malignancies. | Ryuichi Yamamoto Masatomo Takahashi Yasuyo Osafune Katsuya Chinen Shingo Kato Sumiko Nagoshi Koji Yakabi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 12 |
| 2 | Induction of pluripotent stem cells from primary human fibroblasts with only OCT4 and SOX2显示文摘 | Huangfu D Osafune K Maehr R | 2008 | Nat Biotechnol2008，26，： | 1 |
| 3 | Ideal combination of dementia screening tests显示文摘 | Osafune M Deguchi K Abe K | 2014 | Nihon Ronen Igakkai Zasshi2014，51，2： | 1 |
| 4 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2显示文摘 | Huangfu D Osafune K Maehr R | 2008 | Nat Biotechnol2008，26，11： | 1 |
| 5 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2显示文摘 | HUANGFU D OSAFUNE K MAEHR R | 2008 | Nature Biotechnology2008，26，： | 1 |
| 6 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 显示文摘 | Huangfu D Osafune K Maehr R | 2008 | Nat Biotechno12008，26，： | 1 |
| 7 | Induction of pluripotent stem ceils from primary human fibroblasts with only Oct4 and Sox2显示文摘 | Huangfu D Osafune K Maehr R | 2008 | Nature Biotech- nology2008，26，： | 1 |
| 8 | GaAs Ultra-High-Frequency Dividers with Advanced SAINT FET's显示文摘 | Osafune K Enoki T Yamasaki K and Ohwada K | 1986 | IEEE Transactions on Microwave Theory and Techniques1986，34，12： | 1 |
| 9 | Induction of pluripo-tent stem cells from primary human fibroblasts with only Oct4and Sox2显示文摘 | Huangfu D Osafune K Maehr R et a1 | 2008 | Nat Biotechnol2008，26，11： | 1 |
| 10 | Electron microscopic studies onbactericidal effects of electrolyzed acidic water on bacteria derivedfrom kendo protective equipment显示文摘 | OSAFUNE T EHARA T ITO T | 2006 | Environmental Health andPreventive Medicine2006，11，4： | 1 |
| 11 | Electron microscopic studies on bactericidal effects of electrolyzed acidic water on bacteria derived from kando protective equipment显示文摘 | OSAFUNE T EHARA T ITO T | | 0，，04： | 1 |
| 12 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 andSox2显示文摘 | D Huangfu K Osafune R Maehr W Guo | 2008 | Nat Biotechnol2008，26，11： | 1 |
| 13 | Feasibility of large experimental animal models in testing novel therapeutic strategies for diabetes显示文摘Diabetes is among the top 10 causes of death in adults and caused approximately four million deaths worldwide in 2017.The incidence and prevalence of diabetes is predicted to increase.To alleviate this potentially severe situation,safer and more effective therapeutics are urgently required.Mice have long been the mainstay as preclinical models for basic research on diabetes,although they are not ideally suited for translating basic knowledge into clinical applications.To validate and optimize novel therapeutics for safe application in humans,an appropriate large animal model is needed.Large animals,especially pigs, are well suited for biomedical research and share many similarities with humans,including body size,anatomical features,physiology,and pathophysiology.Moreover,pigs already play an important role in translational studies,including clinical trials for xenotransplantation.Progress in genetic engineering over the past few decades has facilitated the development of transgenic animals,including porcine models of diabetes.This article discusses features that attest to the attractiveness of genetically modified porcine models of diabetes for testing novel treatment strategies using recent technical advances. | Masaki Nagaya Koki Hasegawa Ayuko Uchikura Kazuaki Nakano Masahito Watanabe Kazuhiro Umeyama Hitomi Matsunari Kenji Osafune Eiji Kobayashi Hiromitsu Nakauchi Hiroshi Nagashima | 2021 | World Journal of Diabetes2021，12，4： | 1 |
| 14 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2显示文摘 | Huangfu D Osafune K Maehr R | | 0，，11： | 1 |
| 15 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2显示文摘 | Huangfu D Osafune K Maehr R | 2008 | Nat Biotech2008，26，11： | 1 |
| 16 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2显示文摘 | Huangfu D Osafune K Maehr R | 2008 | Nat Biotechnol2008，26，11： | 1 |
| 17 | Characterization of an established cell line from human renal carcinoma显示文摘 | Matsuda M Osafune M Nakano E Kotake T Sononda T Watanabe S | 1979 | Cancer Res1979，39，： | 1 |
| 18 | Induction of pluripotent stem ceils from primary human fibroblasts with only Oct4 and Sox2 显示文摘 | Huangfu Danwei Osafune K Maehr R | 2008 | Nature Biotechnology2008，26，11： | 1 |
| 19 | Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2显示文摘 | Huangfu D Osafune K Maehr R | 2008 | Nature Biotechnol2008，26，11： | 1 |
| 20 | Electron microscopic studies on bactericidal effects of electrolyzed acidic water on bacteria derived from Kendo protective equipment显示文摘 | Osafune T Ehara T Ito T | 2006 | Environ Health Prevent Med2006，，11： | 1 |
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