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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | A method for characterizing a microprocessor's vulnerability to SEU显示文摘 | Elder J H Osborn J Kolasinski W A | 1988 | Nuclear Science IEEE Transactions on1988，35，6： | 1 |
| 3 | Testing and evaluation of nonchromated coating systems for aerospace applications 显示文摘 | Osborne H J Blohowiak K Y Taylor S R | 2001 | Prog Org Coat2001，41，： | 1 |
| 4 | Investigation into the biological stability of collagen/chondroitin-6-sulphate gels and their contraction by fibroblasts and keratinocytes: the effect of crosslinking agents and diamines显示文摘 | Osborne C S Reid W H Grant M H | 1999 | Biomaterials1999，20，3： | 1 |
| 5 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 6 | RFLP mapping of Brassica napus using F1-derived doubled haploid lines显示文摘 | Ferreira M E Williams P H Osborn T C | 1994 | Theor Appl Genet1994，89，： | 1 |
| 7 | The Determinants ofEarnings: A Behavioral Approach显示文摘 | Bowles S Gintis H and Osborne M | 2001 | Journal of EconomicLiterature2001，39，04： | 1 |
| 8 | Mapping factors associate with winter hardiness,fall growth and freezing injury in autotetraploid alfalfa显示文摘 | Duke S H Osborn T C | 2000 | Crop Science2000，40，： | 1 |
| 9 | Toward a systems approach to understanding plant cell walls显示文摘 | SOMERVILLE C BAUER S BRININSTOOL G FACETTE M HAMANN T MILNE J OSBORNE E PAREDEZ A PERSSON S RAAB T VORWERK S YOUNGS H | 2004 | Science2004，306，： | 1 |
| 10 | Stability analysis of an Nth power digital phase-locked loop-part Ⅱ: second and third order DPLL's 显示文摘 | OSBORNE H C | 1980 | IEEE Trans Commuilications1980，28，8： | 1 |
| 11 | Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon- α fusion protein in cynomolgus monkeys显示文摘 | Osborn B L Olsen H S Nardelli B | 2002 | The Journal of Pharmacology and Experimental Therapeutics2002，，2： | 1 |
| 12 | Arandomized trial of vertebroplasty for painful osteoporotic ver-tebral fractures显示文摘 | BUCHBINDER R OSBORNE R H EBELING P R | 2009 | N Engl J Med2009，361，6： | 1 |
| 13 | Non-invasive monitoring of dough mixing by near infrared spectroscopy 显示文摘 | Wesley I J Larsen N Osborne B G Skerritt J H | 1998 | Journal of Cereal Science1998，27，： | 1 |
| 14 | High frequency hearing loss correlated with mutations in the GJB2 gene显示文摘 | Stephen A Wilcox Kerryn Saunders Amelia H Osborn Angela Arnold Julia Wunderlich Therese Kelly Veronica Collins Leah J Wilcox RJ McKinlay Gardner Maria Kamarinos Barbara Cone-Wesson Robert Williamson Hans-Henrik M. Dahl | 2000 | Human Genetics2000，，4： | 1 |
| 15 | Observations on chromate conversion coatings from a sol-gel perspective 显示文摘 | OSBORNE J H | 2001 | Prog Org Coat2001，41，： | 1 |
| 16 | Deinococcns radiodnrans engineered for complete toluene degradation facilitates Cr(Ⅵ) reduction显示文摘 | Brim H Osborne J P Kostandarithes H M | 2006 | Microbiology2006，152，8： | 1 |
| 17 | A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures 显示文摘 | Buchbinder R Osborne R H Ebeling P R | 2009 | N Engl J Med2009，361，6： | 1 |
| 18 | Age-specific Norms and Determinants of Anxiety and Depression in 731 Women with Breast Cancer Recruited through a Population-based Cancer Registry显示文摘 | Osborne R H Elsworth G R Hopper J L | 2003 | Eur J Cancer2003，39，6： | 1 |
| 19 | Estrogen receptor-positive, proges- terone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resist- ance显示文摘 | Arpino G Weiss H Lee A V Schiff R De Placido S Osborne C K | 2005 | J Natl Cancer Inst2005，97，： | 1 |
| 20 | Integrated study of the Judy Field (Block 30/7a): An overpressured central North Sea oil/gas field显示文摘 | Swarbrick R E Osborne M J Grunberger D Yardley G S Macleod G Aplin A C Larter S R Knight I Auld H A | 2000 | Mar Pet Geol2000，17，9： | 1 |
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