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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Development of synthetic Brassica amphidiploids by reciprocal hybridization and comparison to natural amphidiploids显示文摘 | Tang K Osborn T C | 1993 | Theor Appl Genet1993，86，： | 1 |
| 4 | Investigation into the biological stability of collagen/chondroitin-6-sulphate gels and their contraction by fibroblasts and keratinocytes: the effect of crosslinking agents and diamines显示文摘 | Osborne C S Reid W H Grant M H | 1999 | Biomaterials1999，20，3： | 1 |
| 5 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 6 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 7 | Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis显示文摘 | Joinson C O'Callaghan FJ Osborne JP | 2003 | Psychol Med2003，32，2： | 1 |
| 8 | SB 239063,a p38 MAPK inhibitor,reduces neutrophilia,inflammatory cytokines,MMP-9,and fibrosis in lung显示文摘 | Underwood D C Osborn R R Bochnowicz S | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，5： | 1 |
| 9 | Expressed sequenced tags analysis of Atlantic halibut (Hippoglossus hippolossus) liver, kidney and spleen tissues following vaccination against Vibrio anguillarum and Aeromonas salmonicida 显示文摘 | Park K C Osborne J A Tsoi S | 2005 | Fish & Shell Fish Immuno12005，18，： | 1 |
| 10 | RFLP mapping of Brassica napus using F1-derived doubled haploid lines显示文摘 | Ferreira M E Williams P H Osborn T C | 1994 | Theor Appl Genet1994，89，： | 1 |
| 11 | Enhanced target detection and identification via optimized radar transmission pulse shape显示文摘 | GARREN D A OSBORN M K ODON A C | 2001 | IEE Proceedings of Radar Sonar and Navigation2001，148，3： | 1 |
| 12 | Canine pyometra:pathophysiology, diagnosis and treatment of uterine and extra-uterine lesions显示文摘 | Hardy R M Osborne C A | 1974 | J Am An Hosp Ass1974，10，： | 1 |
| 13 | Polyphyletic origin of Brassica nappus: new evidence based on organelle and nuclear RFLP anlysis 显示文摘 | Song K Osborn T C | 1992 | Genome1992，35，： | 1 |
| 14 | Froms of Interorga- nizational Governance for Multinational Alliances显示文摘 | OSBORN R N BAUGHN C C | 1990 | Academy of Management Journal1990，33，3： | 1 |
| 15 | Mechanistic studies of the corrosion inhibitor oleicimid asoline 显示文摘 | EDWARDS A OSBORNE C WEBSTER S etal | 1994 | Corro- sion Science1994，36，2： | 1 |
| 16 | Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women:a prospective combined analysis of two multicenter trials显示文摘 | ROBERTSON J F OSBORNE C K HOWELL A | | 0，，02： | 1 |
| 17 | Managing the acute coronary syn- drome patient: Evidence based recommendations for anti - platelet therapy显示文摘 | Clark MG Beavers C Osborne J | 2015 | Heart Lung2015，44，： | 1 |
| 18 | Development and validation of a spanish diabetes-specific numeracy measure : DNT-15 latino 显示文摘 | White R O Osborn C Y Gebretsadik T | 2011 | Diabetes Technol Ther2011，13，9： | 1 |
| 19 | Mechanisms of tamoxifen resistance:increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer显示文摘 | SHOU J MASSARWEH S OSBORNE C K | 2004 | J Natl Cancer Inst2004，96，12： | 1 |
| 20 | Mapping factors associate with winter hardiness,fall growth and freezing injury in autotetraploid alfalfa显示文摘 | Duke S H Osborn T C | 2000 | Crop Science2000，40，： | 1 |
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