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| 1 | Clinical impact of confocal laser endomicroscopy in the management of gastrointestinal lesions with an uncertain diagnosis显示文摘AIM To evaluate the clinical impact of confocal laser endomicroscopy(CLE) in the diagnosis and management of patients with an uncertain diagnosis.METHODS A retrospective chart review was performed.Patients who underwent CLE between November 2013 and October 2015 and exhibited a poor correlation between endoscopic and histological findings were included.Baseline characteristics,indications,previous diagnostic studies,findings at the time of CLE,clinical management and histological results were analyzed.Interventions based on CLE findings were also analyzed.We compared the diagnostic accuracy of CLE and target biopsies of surgical specimens.RESULTS A total of 144 patients were included.Of these,51%(74/144) were female.The mean age was 51 years old.In all,41/144(28.4%) lesions were neoplastic(13 bile duct,10 gastric,8 esophageal,6 colonic,1 duodenal,1 rectal,1 ampulloma and 1 pancreatic).The sensitivity,specificity,positive predictive value,negative predictive value,and observed agreement when CLE was used to detect N-lesions were 85.37%,87.38%,72.92%,93.75% and 86.81%,respectively.Cohen's Kappa was 69.20%,thus indicating good agreement.Changes in management were observed in 54% of the cases.CONCLUSION CLE is a new diagnostic tool that has a significant clinical impact on the diagnosis and treatment of patients with uncertain diagnosis. | Carlos Robles-Medranda Maria Vargas Jesenia Ospina Miguel Puga-Tejada Manuel Valero Miguel Soria Gladys Bravo Carlos Robles-Jara Hannah Pitanga Lukashok | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，8： | 6 |
| 2 | 甲状腺结节:基于甲状腺癌风险评估的诊断性评价显示文摘甲状腺结节十分常见,通过灵敏的影像学检查在一般人群中的检出率可达到60%以上。大多数患者没有甲状腺相关的临床症状,他们通常在因其他不适就诊检查时发现甲状腺结节。盲目对甲状腺结节进行活检可能造成甲状腺癌的过度诊断,但未能充分完善甲状腺结节活检也可能导致临床漏诊甲状腺癌。最近的临床指南提倡在甲状腺癌风险评估的基础上采用更保守的方法来评估甲状腺结节,即通过临床和超声征象决定活检的必要性。此外,最新证据表明,对于活检无法得出确切结论者,可以通过超声风险分层或其他辅助检查(分子标记物、甲状腺细胞学第二诊疗意见)的联合评估进一步明确甲状腺癌的风险和管理策略。本文总结了对甲状腺结节进行充分评估的临床意义,重点介绍了与明确甲状腺癌风险的诊断性试验相关的临床证据,并强调了在甲状腺癌风险不确定时,考虑患者的价值观和选择倾向的重要性。 | Naykky Singh Ospina Nicole M Iniguez-Ariza M Regina Castro 杨思珏 叶绮婷(译) | 2021 | 英国医学杂志中文版2021，24，9： | 3 |
| 3 | Improved inclination correction method applied to the guidance system of agricultural vehicles显示文摘This research introduces a new inclination correction method with increased accuracy applied to the guidance system of an agricultural vehicle.The method considers the geometry of a robot tractor and uses an Inertial Measurement Unit(IMU)to correct the lateral error of the RTK-GPS antenna measurements raised by the tractor's inclinations.A parameters optimization experiment and an automatic guidance experiment under real working conditions were used to compare the accuracy of a traditional correction method with the new correction method,by calculating the RMSE of the lateral error and the error reduction percentage.An additional tuned correction method was found by using a simple analytical method to find the optimal variables that reduced the lateral error to a minimum.The results indicate that the new correction method and the tuned correction method display a significant error reduction percentage compared to the traditional correction method.The methods could correct the GPS lateral error caused by the roll inclinations in real-time.The resulting lateral deviation caused by the tractor's inclinations could be reduced up to 23%for typical travelling speeds. | Ricardo Ospina Noboru Noguchi | 2020 | International Journal of Agricultural and Biological Engineering2020，13，6： | 2 |
| 4 | 具有不确定参数的温度传感器的动态相对校准(英文)显示文摘存在动态偏差情况下的传感器校准,与多个传感器的相对校准类似.实现相对校准对许多控制问题都很重要,比如需要产生精确温度梯度的问题、保持均匀与稳定温度场的问题.本文以温度传感器为例,对静态(稳态)校准与动态校准从理论和实验两个角度进行了对比.动态校准的一个优势是其适用于任何测量数据,但其需要建立一个测量仪器的动态模型.尽管本文只研究了一个由三个传感器构成的简单设备,但其结果也适用于更复杂的情况.这正是因为动态校准的另一个显著优势,即其能在任何设备上进行校准,校准的一个前提是所用的动态模型与传感器具有相同的阶次.本文证明了可辨识性(可校准性)条件,并通过以迭代方式求解一个非线性加权最小二乘问题,实现了校准.对解的收敛性、一致性和渐近效率,不但给予了理论证明,且通过蒙特卡罗模拟实验进行了验证. | Canuto Enrico Ospina José A Acuna-Bravo Wilber | 2012 | 中国科学技术大学学报2012，42，5： | 2 |
| 5 | Efficacy, safety and lack of immunagenicity of insulin aspart compared with regular human insulin for wowen with gestational diabetes mellitus显示文摘 | Pettitt DJ Ospina P Howard C | 2007 | Diabetic Med2007，24，10： | 1 |
| 6 | Efficacy, safety and lack of immunogenieity of insulin aspart compared with regular humaninsulin for women with gestational diabetes mellitus显示文摘 | Pettitt DJ Ospina P Howard C | 2007 | Diabet Med2007，24，10： | 1 |
| 7 | 17显示文摘 | Ospina J A Krause D N | 2002 | Stroke2002，33，： | 1 |
| 8 | Comparison of an insulin analogue, insulin aspart , and regular human insulin with no insulin in gestational diabetes mellitus 显示文摘 | Pettitt DJ Ospina P Kolaczynski JW | 2003 | Diabetes Care2003，26，： | 1 |
| 9 | Gene profiling of the erythro- and megakaryoblastic leukaemias induced by the Graffi murine retrovirus 显示文摘 | Voisin V Legault P Ospina DP | 2010 | BMC Med Genomies2010，，3： | 1 |
| 10 | Leadership, Diversity and Inclusion: Insights from Scholarship显示文摘 | Ospina S | 2011 | Graduate School of Public Service2011，3，： | 1 |
| 11 | A field trial on the effect of propylene glycol on milk yield and res- olution of ketosis in fresh cows diagnosed with subclinical ketosis显示文摘 | McArt JAA Nydam DV Ospina PA Oetzel GR | 2011 | Journal of Dairy Science2011，94，： | 1 |
| 12 | Estrogen suppresses IL-1 betamediated induction of COX-2 pathway in rat cerebral blood vessels显示文摘 | Ospina JA Brevig HN Krause DN | 2004 | Am J Physiol Heart Circ Physiol2004，286，5： | 1 |
| 13 | Comparison of an insulin analog, insulin aspart, and regular human insulin with no insulin in gestational diabetes mellitus 显示文摘 | Pettitt DJ Ospina P Kolaczynski JW | 2003 | Diabetes Care2003，26，1： | 1 |
| 14 | Probiotics for the prevention of pediatric antibiotic-associated diarrhea显示文摘 | Johnston BC Supina AL Ospina M | 2007 | Cochrane Database Syst Rev2007，18，00： | 1 |
| 15 | Formation of a chronic pain syndrome due to mesh shrinkage after laparoscopic intraperitoneal onlay mesh ( IPOM ) 显示文摘 | Klein F Ospina C Rudolph B | 2012 | Surg Laparosc Endosc Percutan Tech2012，22，5： | 1 |
| 16 | Efficacy,safety and lack of immunogenicity of insulin aspart compared with regular human insulin for women with gestational diabetes mellitus显示文摘 | Pettitt D J Ospina P Howard C | 2007 | Diabet Med2007，24，： | 1 |
| 17 | BriarellinsJ-P and polyanthellin A:new eunicellin-based diterpenes from thegorgonian coral Briareum polyanthes and their antimalarial activity显示文摘 | Ospina C A Rodriguez A D Ortega-Barria E | 2003 | J Nat Prod2003，66，3： | 1 |
| 18 | Protein oligomerization me-diated by the transmembrane carboxyl terminal domain of Bci-xl显示文摘 | Ospina A Lagunas-Martinez A Pardo J | | Febs0，，： | 1 |
| 19 | Transmission of interior concrete column loads through floors 显示文摘 | Ospina C E Alexander S B | 1998 | Journal of Structural Engineering1998，124，6： | 1 |
| 20 | Deflection control of reinforced concrete beams and one-way slabs with externally bonded FRP 显示文摘 | Ospina C E | 2009 | American Concrete Institute ACI Special Publication2009，264，： | 1 |
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