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| 1 | Fertility preservation in female cancer patients:a single center experience显示文摘Advances in cancer treatment allow women to be cured and live longer. However, the necessary chemotherapy and radiotherapy regimens have a negative impact on future fertility. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer treatment and to facilitate fertility preservation, including oocyte and ovarian tissue cryopreservation. These fertility issues are often inadequately addressed, and referral rates to oncofertility centers are low. The aim of this study was to report the 3-year experience of the San Raffaele Oncofertility Unit. A total of 96 patients were referred to the Oncofertility Unit for evaluation after the diagnosis of cancer and before gonadotoxic treatment between April 2011 and June 2014. Of the 96 patients, 30(31.2%) were affected by breast cancers, 20(20.8%) by sarcomas, 28(29.2%) by hematologic malignancies, 13(13.5%) by central nervous system cancers, 3(3.1%) by bowel tumors, 1(1.0%) by Wilms' tumor, and 1(1.0%) by a thyroid tumor; 47(49.0%) were referred for oocyte cryopreservation before starting chemotherapy, 20(20.8%) were referred for ovarian tissue cryopreservation, and 29(30.2%) were not recruited. The mean time between the patients' counseling and oocyte retrieval was 15 days(range, 2–37 days). The mean time between the laparoscopic surgery and the beginning of treatment was 4 days(range, 2–10 days). The number of patients who were referred increased over time, whereas the rate of patients who were not recruited decreased, showing an improvement in referrals to the Oncofertility Unit and in the patients' counseling and understanding. Our results indicate that an effective multidisciplinary oncofertility team is necessary for prompt referrals and treatment. | Cristina Sigismondi Enrico Papaleo Paola Viganò Simona Vailati Massimo Candiani Jessica Ottolina Valentina E. Di Mattei Giorgia Mangili | 2015 | Chinese Journal of Cancer2015，34，1： | 7 |
| 2 | Deep pelvie endometriosis negatively affects ovarian reserve and the number of oocytes retrieved for in vitro fertilization显示文摘 | Papaleo E Ottolina J Vigano P | | 0，，08： | 1 |
| 3 | Biocatalytic properties of Baeyer-Villiger monooxygenases in aqueous-organic media显示文摘 | de Gonzalo G Ottolina G Zambianchi F | 2006 | Mol Catal B Enzyrn2006，39，： | 1 |
| 4 | Cp·Rh(bpy)(H2O)]^2+ as a coenzyrne substitute in enzymatic oxidations catalyzed by Baeyer-Villiger monooxygenases显示文摘 | de Gonzalo G Ottolina G Carrea G | 2005 | Chem Commun2005，29，： | 1 |
| 5 | Deep pelvic endo- metriosis negatively affects ovarian reserve and the number of oocytes retrieved for in vitro fertilization 显示文摘 | Papaleo E Ottolina J Viganb P | 2011 | Acta Obstet Gynecol Scand2011，90，8： | 1 |
| 6 | Selectivity-enhancement of hydrolase reactions 显示文摘 | Faber S K Ottolina G Riva S | 1993 | Biocatal Biotransform1993，8，2： | 1 |
| 7 | Oxidations catalyzed by phenylacetone monooxygenase from Thermobifida fusca显示文摘 | Gonzalo G Pazmino D E T Ottolina G | 2005 | Tetrahedron: Asymmetry2005，16，： | 1 |
| 8 | A predictive active site model for the cyclohexanone monooxygenase catalyzed oxidation of sulfides to chiral sulfoxides 显示文摘 | Ottolina G Pasta P Carrea G Colonna S | 1995 | Tetrahedron: Asymmetry1995，6，： | 1 |
| 9 | Preparative-scale separation by simulated moving bed chromatography of biocatalytically produced regioisomeric lactones显示文摘 | Kaiser P Ottolina G Carrea G | 2009 | New Biotechnology2009，25，4： | 1 |
| 10 | Systemic capillary leak syndrome:is methylene blue the silver bullet 显示文摘 | Umbrello M Gardinali M Ottolina D | 2014 | Case Rep Crit Care2014，141，20： | 1 |
| 11 | Enzymatic Baeyer-Villiger oxidation ofbicyclic diketones 显示文摘 | OTTOLINA G GONZOLO G CARREA G | 2005 | Adv Synth Catal2005，347，： | 1 |
| 12 | Selectivity - enhancement of hydrolase reactions显示文摘 | Faber S K Ottolina G Riva S | 1993 | Biocatalysis1993，8，： | 1 |
| 13 | Selectivity-enhance- ment of hydrolase reactions 显示文摘 | FABER K OTTOLINA G RIVA S | 1993 | Biocatal Biotransform1993，8，2： | 1 |
| 14 | Modification of lipase from Pseudomonassp,with poly (acryloyl morpholine) and study of its catalytic properties in orgamic solvents显示文摘 | Bovara R Ottolina G Carea G | | 0，，： | 1 |
| 15 | Deep pelvic endo- metriosis negatively affects ovarian reserve and the num- ber of oocytes retrieved for in vitro fertilization显示文摘 | Papaleo E Ottolina J Viganb P | 2011 | Acta Obstet Gynecol Scand2011，90，8： | 1 |
| 16 | Deep pelvic endometriosis negatively affects ovarian reserve and the number of oocytes retrieved for in vitro fertilization显示文摘 | Papaleo E Ottolina J Vigano P | 2011 | Acta Obstet Gynecol Scand2011，90，8： | 1 |
| 17 | Deep pelvic endometfiosis negatively affects ovarian reserve and the number of ooeytes retrieved for in vitro fertilization 显示文摘 | Papaleo E Ottolina J Yiganb P | 2011 | Aeta Obstet Gyneeol Stand2011，90，8： | 1 |
| 18 | Role of solvents in the control of enzy me selectivity in organic media显示文摘 | Ottolina G Riva S | 1995 | Tibtech February1995，13，： | 1 |
| 19 | 4- Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB as an oxidative biocatalyst in the synthesis of optically active sulfoxides 显示文摘 | GONZALO G PAZMINO D E T OTTOLINA G | 2006 | Tetrahedron: Asymmetry2006，17，1： | 1 |
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