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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxiainducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells显示文摘 | Razorenova OV Castellini L Colavitti R | 2014 | Mol Cell Biol2014，34，： | 1 |
| 3 | Calcium signaling and pancreatic cell death: apoptpsis or necrosis? 显示文摘 | Criddle DN Gerasimenko JV Baumgartner HK Jaffar M Voronina S Sutton R Petersen OH Gerasimenko OV | 2007 | Cell Death Differ2007，14，7： | 1 |
| 4 | Insulin resistance polycystic ovary syndrome and type 2 diabetes mellitus显示文摘 | Ov Ule F Azziz R | 2002 | Feail Steril2002，77，6： | 1 |
| 5 | Idl regulates angiogenesis through transcriptional repression of thrombospondin-1显示文摘 | Volpert OV Pili R Sikder HA | 2002 | Cancer Ce112002，2，6： | 1 |
| 6 | Do CSF total tau, phosphorylated tau, and beta - amyloid 42 help top redict progression of mild cognitive impairment to Alzheimerps disease? A systematic review and meta - analysis of the literature显示文摘 | DinizBS Pinto JA J r Forlenza OV | 2008 | World J Biol Psychiatry2008，9，3： | 1 |
| 7 | Idl regulates angiogenesis through transcriptional repression of thrombospondin-1 显示文摘 | Volpert OV Pili R Sikder HA | 2012 | Cancer cell2012，2，6： | 1 |
| 8 | Root anatomy and canal configuration of the permanent mandibular first molar : a systematic review 显示文摘 | de Pablo OV Estevez R P6ix Sdnchez M | 2010 | J Endod2010，36，12： | 1 |
| 9 | Idl regulates angiogenesis through transcriptional repression of thrombospondin-1 显示文摘 | Volpert OV Pili R Sikder HA | 2002 | Cancer Cell2002，2，： | 1 |
| 10 | Influence of effluent irrigation on community composition and function of ammonia- oxidizing bacteria in soil 显示文摘 | OVED T SHAVIV A GOLDRATH T MANDELBAUM R T MINZ D | 2001 | Applied and Environmental Microbiology2001，67，8： | 1 |
| 11 | Gas chromatographic-mass spectrometric characterization of monomethylalkanes from fuel diesel显示文摘 | Krko?ová ? Kubinec R Addová G | 2007 | Petroleum & Coal2007，49，3： | 1 |
| 12 | Id1 regulates angiogenesis through transcriptional repression of thromhospondin-1显示文摘 | Volpert OV Pili R Sikder HA | 2002 | Cancer Cell2002，2，6： | 1 |
| 13 | Zucker diabetic fatty rat:a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity显示文摘 | Slavkovsky R Kohlerova R Tkacova V Jiroutova A Tahmazoglu B Velebny V Reza?ováM Sobotka L Kanta J | 2011 | Wound Repair Regen2011，19，4： | 1 |
| 14 | Bioconversion of lignocellulosic biomass: biochemical and molecular perspectives 显示文摘 | Kumar R Singh S Singh OV | 2008 | Journal of Industrial Microbiology Biotechnology2008，35，5： | 1 |
| 15 | Heterogeneous RNA-binding protein Md is a receptor for carcinoembryonic antigen in Kupffer cells 显示文摘 | Bajenova OV Zimmer R Stolper E | 2001 | J Biol Chem2001，276，31： | 1 |
| 16 | Caries induced cytokine network in the odontoblast layer of human teeth 显示文摘 | Horst OV Horst J A Samudrala R | 2011 | BMC Immunol2011，12，： | 1 |
| 17 | Idl regulates angiogenesis through transcriptional repression of thrombospondin-1 显示文摘 | Volpert OV Pili R Sikder HA | 2002 | Cancer Cell2002，2，6： | 1 |
| 18 | Trimodality imaging of colonic lymphoma显示文摘 | J. Cyrany M. Pintér V. Ty?ová J. Krejsek D. Belada S. Rejchrt J. Bure? | 2009 | Endoscopy (S )2009，，02： | 1 |
| 19 | Improvement of the stability of glucose oxidase via encapsulation in sodium alginate–cellulose sulfate–poly(methylene- co -guanidine) capsules显示文摘 | Alica Vikartovská Marek Bu?ko Danica Mislovi?ová Vladimír P?toprsty Igor Lacík Peter Gemeiner | 2007 | Enzyme and Microbial Technology2007，，6： | 1 |
| 20 | Development of a DNA probe and a PCR based diagnostic assay for Rhizoctonia solani using a repetitive DNA sequence cloned from a Sri Lankan isolate 显示文摘 | Weerasena OV Chandrasekharan NV Wijesundera R L | 2004 | Mycological Research2004，108，6： | 1 |
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