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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Flocculation behaviour and mechanisms of cationic inorganic micro-particle/polymer systems显示文摘 | Xiao Huining | 2002 | Colloids and Surface A:Physicochemical and Engineering Aspects2002，197，123： | 1 |
| 3 | Agri-environment schemes and their contribution to the conservation of biodi- versity in England显示文摘 | Ovenden G N Swash A R H Smallshire D | 1998 | Journal of Applied Ecology1998，35，6： | 1 |
| 4 | , Wiseman N, Retentlon aid systems of cationic microparticles and anionic polymer: experiments and pilot machine trials显示文摘 | Ovenden C Xiao H | 2000 | Tappi J2000，83，3： | 1 |
| 5 | Mitochondrial DNA restriction site map for Gadopsis marmoratus显示文摘 | Ovenden J R White R W G | 1988 | Biochemical Systematics and Ecology1988，16，3： | 1 |
| 6 | Sesquiter pene Benzoxazoles and Sesquiterpene Quinones from the Marine Sponge Dactylospongia elegans 显示文摘 | Ovenden S P B Nielson J L Liptrot C H el al | 2011 | J Nat Prod2011，74，1： | 1 |
| 7 | Flocculation behaviour and mechanisms of cationic microparticle/polymer systems显示文摘 | Cherie Ovenden Xiao Huining | | 0，，： | 1 |
| 8 | Floeculation behaviour and mechanisms of cationic inorganic microparticie/polymer systems 显示文摘 | Ovenden C Xiao H | 2002 | Colloid Surface A2002，197，： | 1 |
| 9 | Mode matching strategies in slowly varying engine duets显示文摘 | Ovenden N C Rienstra S W | 2004 | AIAA Journal2004，42，9： | 1 |
| 10 | Genetic population structure of mangrove jack,Lutjanus argentimaculatus (Forsskal)显示文摘 | OVENDEN J R STREET R | 2003 | Marine and Freshwater Research2003，54，2： | 1 |
| 11 | Mode-matching strategies inslowly varying engine ducts显示文摘 | Ovenden N C Rienstra S W | 2004 | AIAA Journal2004，42，9： | 1 |
| 12 | Real options analysis of investment in carbon capture and sequestration technology显示文摘 | HEYDARI S OVENDEN N SIDDIQUI A | 2010 | Computational Management Science2010，9，1： | 1 |
| 13 | Retention aid systems of cationic micro-particles and anionic polymer:experiments and pilot machine trials显示文摘 | Ovenden Cherie Xiao Hui ning Wiseman Nicholas | 2000 | Tappi Joumal2000，83，3： | 1 |
| 14 | Globoidnan A:a lignan from Eucalyptus globoidea inhibits HIV integrase显示文摘 | Yu J Wan SS | 2004 | Phytochemistry2004，65，： | 1 |
| 15 | Physaloside A, an acylated sucrose ester from physalis viscose 显示文摘 | OVENDEN S P B YU J BERNAYS J | 2005 | J Nat Proct2005，68，： | 1 |
| 16 | Retention aid systems of cationic microparticles and anionic polymer: experiments and pilot machine trials显示文摘 | Ovenden C Xiao H Wiseman N | 2000 | Tappi J2000，83，3： | 1 |
| 17 | Real options analysis of investment in carbon capture d sequestration technology 显示文摘 | HEYDARI S OVENDEN N SIDDQUI A | 2010 | Computational Management Science2010，9，1： | 1 |
| 18 | Flocculation behaviour and mechanisms of cationic inorganic microparticle/polymer systems 显示文摘 | Ovenden Cherie Xiao Huining | 2002 | Colloids and Surfaces A:Physicochemical and Engineering Aspect2002，197，： | 1 |
| 19 | Physaloside a, an acylated sucrose ester from pHysalis viscose显示文摘 | OVENDEN S P B YU Jin BERNAYS J | 2005 | J Nat Prod2005，68，： | 1 |
| 20 | A diketopiperazine dimer from a marine-derived isolate of Aspergillus niger 显示文摘 | Ovenden S P Sberna G Tait R M | 2004 | J Nat Prod2004，67，12： | 1 |
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