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| 1 | Review of a challenging clinical issue:Intrahepatic cholestasis of pregnancy显示文摘Intrahepatic cholestasis of pregnancy(ICP) is a reversible pregnancy-specific cholestatic condition characterized by pruritus, elevated liver enzymes, and increased serum bile acids. It commences usually in the late second or third trimester, and quickly resolves after delivery. The incidence is higher in South American and Scandinavian countries(9.2%-15.6% and 1.5%, respectively) than in Europe(0.1%-0.2%). The etiology is multifactorial where genetic, endocrine, and environmental factors interact. Maternal outcome is usually benign, whereas fetal complications such as preterm labor, meconium staining, fetal distress, and sudden intrauterine fetal demise not infrequently lead to considerable perinatal morbidity and mortality. Ursodeoxycholic acid is shown to be the most efficient therapeutic agent with proven safety and efficacy. Management of ICP consists of careful monitoring of maternal hepatic function tests and serum bile acid levels in addition to the assessment of fetal well-being and timely delivery after completion of fetal pulmonary maturity. This review focuses on the current concepts about ICP based on recent literature data and presents an update regarding the diagnosis and management of this challenging issue. | Sebiha Ozkan Yasin Ceylan Orhan Veli Ozkan Sule Yildirim | 2015 | World Journal of Gastroenterology2015，21，23： | 53 |
| 2 | Aetiology of idiopathic granulomatous mastitis显示文摘Idiopathic granulomatous mastitis is a rare chronic inflammatory lesion of the breast that can clinically and radiographically mimic breast carcinoma. The most common clinical presentation is an unilateral, discrete breast mass, nipple retraction and even a sinus formation often associated with an inflammation of the overlying skin. The etiology of idiopathic granulomatous mastitis is still obscure. Its treatment remains controversial. The cause may be the autoimmune process, infection, a chemical reaction associated with oral contraceptive pills, or even lactation. Various factors, including hormonal imbalance, autoimmunity, unknown microbiological agents, smoking and α 1-antitrypsin deficiency have been suggested to play a role in disease aetiology. In this review, causing factors in the aetiology of idiopathic granulomatous mastitis are reviewed in detail. | Fatih Altintoprak Taner Kivilcim Orhan Veli Ozkan | 2014 | World Journal of Clinical Cases2014，2，12： | 52 |
| 3 | Gastrointestinal bezoars: A retrospective analysis of 34 cases显示文摘AIM: Bezoars (BZ) are the most common foreign bodies of gastrointestinal tract. Clinical manifestations vary depending on the location of BZ from no symptoms to acute abdominal syndrome. When located in small bowel, they frequently cause small bowel obstruction (SBO). We aimed to present our experience by reviewing literature.METHODS: Thirty-four patients with gastrointestinal BZ were presented. The data were collected from hospital records and analyzed retrospectively. Morbidity and mortality rates were statistically analyzed between the subgroups according to SBO and endoscopic or surgical treatment modalities.RESULTS: The 34 patients had phytobezoars (PBZ). Two patients with mental retardation and trichotillomania had trichobezoars (TBZ). More than half of them (55.88%) had previous gastric surgery. Also most of them had small bowel bezoars resulting in obstruction. Surgical and endoscopic morbidity rates were 32.14% and 14.28% respectively.The total morbidity rate of this study was 29.41%. Four patients in surgically treated group died. There was no death in endoscopically treated group. The total and surgical mortality rates were 11.76% and 14.28% respectively. The differences in morbidity and mortality rates between the subgroups were not statistically significant.CONCLUSION: BZ are commonly seen in stomach and small intestine. SBO is the most common complication.When uncomplicated, endoscopic or surgical removal can be applied easily. | Kenan Erzurumlu Zafer Malazgirt Ahmet Bektas Adem Dervisoglu Cafer Polat Gokhan Senyurek Ibrahim Yetim Kayhan Ozkan | 2005 | World Journal of Gastroenterology2005，11，12： | 33 |
| 4 | Effects of resveratrol and methylprednisolone on biochemical,neurobehavioral and histopathological recovery after experimental spinal cord injury显示文摘瞄准:在损害(SCI ) 在老鼠建模的试验性的脊髓调查 resveratrol 的 neuroprotective 效果。方法:男 Wistar 白鼠称 200-250 g 被使随机化进六个组。重量落下损伤为 SCI 被执行。组 1 独自经历了椎板切除术。组 2 经历了 SCI 跟随的椎板切除术。3, 4, 5,和 6 经历了的组 SCI 跟随并且收到了 resveratrol (100 mg/kg ) 的椎板切除术,甲基氢化尼松(MP )(30 mg/kg ) ,加 MP (30 mg/kg ) 的 resveratrol (100 mg/kg ) ,和乙醇(2%) 分别地。老鼠为生物化学的分析被划分成二亚群(在外科以后在 24 点杀死了 h ) 并且为 neurobehavioral 和组织病理学说的评估(在外科以后在 6 点杀死了星期) 。在外科以后的 Posttraumatic 神经病学的恢复每周被记录。结果:3 和 5 揭示了的组显著地比组织 4 降低 malon-dialdehyde,氮的氧化物,黄嘌呤氧化酶,和更高的谷胱甘肽层次(P<0.05 ) 。神经病学的恢复率显著地更好在比组织 4 组织 3 和 5 (P<0.05 ) 。当针的损伤尺寸比率被比较时,在治疗组之间没有有效差量。结论:Resveratrol 处理比 MP 处理在损伤的尖锐阶段揭示了更好生物化学的恢复。尽管 resveratrol 和联合处理比 MP 处理揭示了更好的 neurobehavioral 恢复;resveratrol, MP,和联合处理形式在实验的最后的阶段在一样的水平改进了组织病理学说的恢复。当每药有行动的不同抗氧化的机制,与 MP 包含 resveratrol 和不同剂量联合的不同剂量的未来研究能答应更好的结果。 | Ozkan ARIES Suleyman CAYLI Eyup ALTINOZ Iclal GURSES Neslihan YUCEL Ayhan KOCAK Saim YOLOGLU Yusuf TURKOZ | 2006 | Acta Pharmacologica Sinica2006，27，10： | 18 |
| 5 | Endoscopic retrograde cholangiopancreatography during pregnancy without radiation显示文摘AIM: To present our experience with pregnant patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) without using radiation, and to evaluate the acceptability of this alternative therapeutic pathway for ERCP during pregnancy. METHODS: Between 2000 and 2008, six pregnant women underwent seven ERCP procedures. ERCP was performed under mild sedoanalgesia induced with pethidine HCl and midazolam. The bile duct was cannulated with a guidewire through the papilla. A catheter was slid over the guidewire and bile aspiration and/or visualization of the bile oozing around the guidewire was used to confirm correct cannulation. Following sphincterotomy, the bile duct was cleared by balloon sweeping. When indicated, stents were placed. Confirmation of successful biliary cannulation and stone extraction was made by laboratory, radiological and clinical improvement. Neither fluoroscopy nor spot radiography was used during the procedure. RESULTS: The mean age of the patients was 28 years (range, 21-33 years). The mean gestational age for the fetus was 23 wk (range, 14-34 wk). Five patients underwent ERCP because of choledocholithiasis and/orcholedocholithiasis-induced acute cholangitis. In one case, a stone was extracted after precut papillotomy with a needle-knife, since the stone was impacted. One patient had ERCP because of persistent biliary fistula after hepatic hydatid disease surgery. Following sphincterotomy, scoleces were removed from the common bile duct. Two weeks later, because of the absence of fistula closure, repeat ERCP was performed and a stent was placed. The fistula was closed after stent placement. Neither post-ERCP complications nor premature birth or abortion was seen. CONCLUSION: Non-radiation ERCP in experienced hands can be performed during pregnancy. Stent placement should be considered in cases for which complete common bile duct clearance is dubious because of a lack of visualization of the biliary tree. | Adem Akcakaya Orhan Veli Ozkan Ismail Okan Orhan Kocaman Mustafa Sahin | 2009 | World Journal of Gastroenterology2009，15，29： | 17 |
| 6 | Platinum-induced neurotoxicity: A review of possible mechanisms显示文摘Patients treated with platinum-based chemotherapy frequently experience neurotoxic symptoms, which may lead to premature discontinuation of therapy. Despitediscontinuation of platinum drugs, these symptoms can persist over a long period of time. Cisplatin and oxaliplatin, among all platinum drugs, have significant neurotoxic potential. A distal dose-dependent symmetrical sensory neuropathy is the most common presentation of platinum neurotoxicity. DNA damage-induced apoptosis of dorsal root ganglion(DRG) neurons seems to be the principal cause of neurological symptoms. However, DRG injury alone cannot explain some unique symptoms such as cold-aggravated burning pain affecting distal extremities that is observed with oxaliplatin administration. In this article, we briefly reviewed potential mechanisms for the development of platinum drugs-associated neurological manifestations. | Ozkan Kanat Hulya Ertas Burcu Caner | 2017 | World Journal of Clinical Oncology2017，8，4： | 14 |
| 7 | Targeted therapy for advanced gastric cancer: A review of current status and future prospects显示文摘In the West in particular, the vast majority of gastric cancer(GC) patients present with advanced-stage disease. Although combination chemotherapy is stillthe most important component of treatment for these patients, it confers a modest survival advantage. Recently, increased knowledge of the key molecular signaling pathways involved in gastric carcinogenesis has led to the discovery of specific molecular-targeted therapeutic agents. Some of these agents such as trastuzumab and ramucirumab have changed the treatment paradigm for this disease. In this paper, we will summarize the current clinical status of targeted drug therapy in the management of GC. | Ozkan Kanat Bert O'Neil Safi Shahda | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 8 | Rare etiology of mechanical intestinal obstruction: Abdominal cocoon syndrome显示文摘Abdominal cocoon syndrome is a rare cause of intestinal obstruction with unknown etiology. Diagnosis of this syndrome, which can be summarized as the small intestine being surrounded by a fibrous capsule not containing the mesothelium, is difficult in the preoperative period. A 47-year-old male patient was referred to the emergency department with complaints of abdominal pain, nausea, and vomiting for two days. The abdominal computed tomography examination detected dilated small intestinal loops containing air-fluid levels clustered in the left upper quadrant of the abdomen and surrounded by a thick, saclike, contrast-enhanced membrane. During exploratory surgery, a capsular structure was identified in the upper left quadrant with a regular surface that was solid-fibrous in nature. Ab-dominal cocoon syndrome is a rarely seen condition, for which the preoperative diagnosis is difficult. The combination of physical examination and radiological signs, and the knowledge of 'recurrent characteristics of the complaints' that can be learned by a careful history, may be helpful in diagnosis. | Yener Uzunoglu Fatih Altintoprak Omer Yalkin Yasemin Gunduz Guner Cakmak Orhan V Ozkan Fehmi Celebi | 2014 | World Journal of Clinical Cases2014，2，11： | 13 |
| 9 | Exp-Function Method and Fractional Complex Transform for Space-Time Fractional KP-BBM Equation显示文摘In the present article, He's fractional derivative, the ansatz method, the(G′/G)-expansion method, and the exp-function method are used to construct the exact solutions of nonlinear space-time fractional Kadomtsev–Petviashvili–Benjamin–Bona–Mahony(KP-BBM). As a result, different types of exact solutions are obtained. Also we have examined the relation between the solutions obtained from the different methods. These methods are an efficient mathematical tool for solving fractional differential equations(FDEs) and it can be applied to other nonlinear FDEs. | Ozkan Guner | 2017 | Communications in Theoretical Physics2017，67，8： | 10 |
| 10 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
| 11 | Intestinal obstruction due to phytobezoars: An update显示文摘The term bezoar refers to an intraluminal mass in the gastrointestinal system caused by the accumulation of indigestible ingested materials, such as vegetables, fruits, and hair. Bezoars are responsible for 0.4%-4% of cases of mechanical intestinal obstruction. The clinical findings of bezoar-induced ileus do not differ from those of mechanical intestinal obstruction due to other causes. The appearance and localization of bezoars can be established with various imaging methods. Treatment of choice depends on the localization of the bezoar which makes the clinical findings. | Enis Dikicier Fatih Altintoprak Orhan Veli Ozkan Orhan Yagmurkaya Mustafa Yener Uzunoglu | 2015 | World Journal of Clinical Cases2015，3，8： | 7 |
| 12 | Effect of early preoperative 5-fluorouracil on the integrity of colonic anastomoses in rats显示文摘AIM:To determine the effect of chemotherapy on wound healing by giving early preoperative 5-fluorouracil (5-FU)to rats with colonic anastomoses. METHODS:Sixty Albino-Wistar male rats(median weight,235 g)were used in this study.The rats were fed with standard laboratory food and given tap water ad libitum.The animals were divided into three groups: Group 1:Control group(chemotherapy was not administered),Group 2:Intraperitoneally(IP)administered 5-FU group(chemotherapy was administered IP to animals at a dose of 20 mg/kg daily during the 5 d preceeding surgery),Group 3:Intravenously(IV)administered 5-FU group.Chemotherapy was administered via the penil vein,using the same dosing scheme and duration as the second group.After a 3-d rest to minimize the side effects of chemotherapy,both groups underwent surgery.One centimeter of colon was resected 2 cm proximally from the peritoneal reflection,thensutured intermittently and subsequently end-to-end anastomosed.In each group,half the animals were given anaesthesia on the 3rd postoperative(PO)day and the other half on the 7th PO day,for in vivo analytic procedures.The abdominal incisions in the rats were dissected,all the new and old anastomotic segments were clearly seen and bursting pressures of each anastomotic segment,tissue hydroxyproline levels and DNA content were determined to assess the histologic tissue repair process. RESULTS:When the IV group was compared with the IP group,bursting pressures of the anastomotic segments on the 3rd and 7th PO days,were found to be significantly decreased,hydroxyproline levels at the anastomotic segment on the 7th PO day were significantly decreased(P<0.01). CONCLUSION:In this study,we conclude that early preoperative 5-FU,administered IV,negatively affects wound healing.However,IP administered 5-FU does not negatively affect wound healing. | Leyla Ozel M Sefa Ozel Ahmet Burak Toros Melih Kara Kemal Sirri Ozkan Gurkan Tellioglu Osman Krand Meral Koyuturk Ibrahim Berber | 2009 | World Journal of Gastroenterology2009，15，33： | 7 |
| 13 | Bright and dark soliton solutions for some nonlinear fractional differential equations显示文摘In this work, we propose a new approach, namely ansatz method, for solving fractional differential equations based on a fractional complex transform and apply it to the nonlinear partial space–time fractional modified Benjamin–Bona–Mahoney(m BBM) equation, the time fractional m Kd V equation and the nonlinear fractional Zoomeron equation which gives rise to some new exact solutions. The physical parameters in the soliton solutions: amplitude, inverse width, free parameters and velocity are obtained as functions of the dependent model coefficients. This method is suitable and more powerful for solving other kinds of nonlinear fractional PDEs arising in mathematical physics. Since the fractional derivatives are described in the modified Riemann–Liouville sense. | Ozkan Guner Ahmet Bekir | 2016 | Chinese Physics B2016，25，3： | 6 |
| 14 | Salinization Increase due to Climate Change Will Have Substantial Negative Effects on Inland Waters: A Call for Multifaceted Research at the Local and Global Scale显示文摘Globally,temperature and precipitation patterns are predicted to change markedly as a result of climate change.Particularly,the regions with a cold or hot semi-arid climate and the Mediterranean climate zone are expected to be strongly affected.1,2 A 25%–30%decrease in precipitation and increased evaporation are expected by the end of the 21st century in the Mediterranean region,to be accompanied by an even stronger reduction in runoff of up to 30%–40%,1,2 and this will lead to increasing salinization of lakes in these areas. | Erik Jeppesen Meryem Beklioglu Korhan Ozkan Zuhal Akyurek | 2020 | The Innovation2020，1，2： | 6 |
| 15 | Corporate cash holdings: An empirical investigation of UK companies显示文摘 | Aydin Ozkan Neslihan Ozkan | 2003 | Journal of Banking and Finance2003，，9： | 6 |
| 16 | Driver sleepiness,fatigue,careless behavior and risk of motor vehicle crash and injury:Population based case and control study显示文摘Background: A few studies have been conducted to determine the relationship between road motor vehicle crashes(MVC) and serious injuries related to tiredness, fatigues and sleeping.Aim: To determine the effects of aggressive behaviour, driver sleepiness and fatigue on MVC and related injuries among Turkish population.Design and setting: Population-based case and control study conducted at the accident emergency departments of hospitals and roads.Subjects: 515 car drivers involved in crashes with injury were admitted to hospital and 1030 car drivers involved while driving on public roads as control group during the study period.Methods: The Manchester driver behaviour questionnaire(DBQ) measured the aberrant driving behaviours leading to accidents. Participants completed a fatigue severity scale(FSS) and Stanford Sleeping questionnaire an epworth scale with items related to sociodemographic information, driving experiences, adherence to traffic laws(such as speed limits and seat belt), and drivers' driving records.Results: In a representative sampling, participant's age ranged from 25 to 65 and the mean and standard deviation were 36.5 ± 7.8 for cases and 37.0 ± 8.0 for controls. There was a significant difference in both group of drivers regarding BMI, level of education, marital status, driving experience, seat belt use, excessive speed limits, physical activity number of sleeping hours, mobile phone use, and cigarette smoking habit(p = 0.017). Also, there was a significant higher mean score on all the DBQ violation questions among case group in comparison with the control group(p < 0.001). Further, cases had higher prevalence of Epworth sleeping disorders(p < 0.001) and fatigue severity(p = 0.003) compared to control drivers. Multivariate logistic regression revealed that excessive speed, fatigue, lapses, errors, Stanford sleepiness score, violations, mobile phone use and Epworth sleepiness scale were significantly associated with injury involvement in vehicle crash, after adjusting for driving experience and annual mileage.Conclusion: The current study confirmed that drivers with chronic fatigue, acute sleepiness,and careless driver behavior may significantly increases the risk of road crash which can be lead to serious injury. | Abdulbari Bener Erol Yildirim Turker Ozkan Timo Lajunen | 2017 | Journal of Traffic and Transportation Engineering(English Edition)2017，4，5： | 5 |
| 17 | Mechanical lithotripsy and/or stenting in management of difficult common bile duct stones显示文摘BACKGROUND:Mechanical lithotripsy and/or stent insertion is the alternative therapeutic approach in difficult endoscopic retrograde cholangiopancreatography (ERCP)case.This study was designed to investigate the appropriate treatment for extraction of bile duct stones in difficult cases of ERCP. METHODS:Between 2000 and 2008,744 ERCP procedures were performed in 592 patients with choledocholithiasis in our endoscopy unit.The demographic features,and clinical and laboratory findings were collected from a prospectively held database.Bile duct calculi were extracted by basket and/or balloon catheter following ERCP and sphincterotomy.Patients with retained stones were regarded as difficult cases.These patients were treated with mechanical lithotripsy and those with incomplete clearance of stones underwent stent placement. RESULTS:Two hundred and forty-five patients(41%) were male and 347(59%)were female with a mean age of 58 years(range 19-95 years).Stones were impacted in 27 patients(5%).Stone extraction was performed by basket and/or balloon catheter in 610 ERCP procedures,and lithotripsy was performed in 70 ERCP procedures.Forty- four patients underwent stent insertion,and 20 underwent stent replacement.Morbidity occurred in 39 patients (5%),with no mortality associated with the procedure.Hemorrhage occurred in 9 patients and basket impaction in 4.Mild pancreatitis and cholangitis developed in 12 and 11 patients,respectively. CONCLUSION:Difficult cases of bile duct stones can be treated successfully with lithotripsy,and a stent should be applied when the common bile duct cannot be cleared completely. | Adem Akcakaya Orhan Veli Ozkan Gurhan Bas Atilla Karakelleoglu Orhan Kocaman Ismail Okan Mustafa Sahin | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，5： | 5 |
| 18 | Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats显示文摘Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis. | Adem Bozkurt Aras Mustafa Guven Tar?k Akman Adile Ozkan Halil Murat Sen Ugur Duz Y?ld?ray Kalkan Coskun Silan Murat Cosar | 2015 | Neural Regeneration Research2015，10，1： | 4 |
| 19 | 低功率超声强化方铅矿-乙基黄原酸钾浮选体系显示文摘研究在乙基黄原酸钾(KEX)存在的条件下利用超声提高方铅矿可浮性的可能性。为此,除表面化学研究外,还进行微浮选实验,包括测量不同超声功率水平和调节时间时的Zeta电势、接触角和气泡-颗粒粘附时间。研究结果表明,当超声功率为30 W、调节时间为2 min时浮选回收率最大,为77.5%。另外,使用超声后获得更负的Zeta电势、更大的接触角和更短的气泡-颗粒粘附时间,表明超声作用使方铅矿的疏水性增加。 | Can GUNGOREN Yasin BAKTARHAN Ismail DEMIR Safak Gokhan OZKAN | 2020 | Transactions of Nonferrous Metals Society of China2020，30，4： | 4 |
| 20 | Current treatment options for patients with initially unresectable isolated colorectal liver metastases显示文摘The development of liver metastases is a common clinical entity in the clinical course of colorectal cancer. For patients with isolated liver involvement, surgical resection is the only treatment that can provide a chance of prolonged survival and cure. However, most of these patients are not initially eligible for the surgery. Selected patients with initially considered to have unresectable disease may become resectable after systemic(che-motherapy ± biological therapy) and loco-regional treatment modalities including hepatic arterial infusion. Patients who have colorectal liver metastases ideally should be referred to a multidisciplinary cancer care team in order to identify the most optimal management approach. | Ozkan Kanat | 2016 | World Journal of Clinical Oncology2016，7，1： | 3 |
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