|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 2 | Rennet coagulation of skim milk and curd drainage: effect of pH, casein concentration, ionic strength and heat treatment显示文摘 | C LINA D MARIE-HILtNE F ALICE P | 2000 | Dairy Sciences and Technology2000，80，4： | 1 |
| 3 | Protein enrichment of potato pro- cessing waste through yeast fermentation 显示文摘 | Ge' linas P Barrette J | 2007 | Bioresource Technology2007，98，5： | 1 |
| 4 | Protein enrichment of potato processing waster through yeast fermentation显示文摘 | P G e linas J Barrette | 2007 | Bioresource Technology2007，，9： | 1 |
| 5 | Public health awareness of e-merging zoonotic viruses of bats:a European perspective显示文摘 | Van P W Lina P H Kramps J A | 2006 | Vector Borne Zoonotic Dis2006，6，4： | 1 |
| 6 | Operation of remote mobile sensors for security of drinking water distribution systems显示文摘 | Lina P Avi O | 2013 | Water Research2013，47，： | 1 |
| 7 | Analysis of the genetic variability of genes encoding the RNA hi-activating compo- nents Agr and TRAP in a population of Staphylococcus aureus strains isolated from cows with mastitis 显示文摘 | Gilot P Lina G Cochard T | 2002 | J Clin Microbi- ol2002，40，11： | 1 |
| 8 | Residual pattern of fenhexamld on pepper fruits grown under green- house conditions using HPLC and confirmation via tandem mass spectrometry显示文摘 | LINA H JEONG - HEUI C JONG - HYOUK P | 2011 | Food chemistry2011，126，4： | 1 |
| 9 | Current perspectives on milk hyper-sensitivity显示文摘 | Leea P Lina L and Esa-Matti L | 1999 | Trend in food science & technology1999，，10： | 1 |
| 10 | Annexin 1 :the new face of an old molecule 显示文摘 | Lina I-IK Shazib P | 2007 | FASEB2007，21，4： | 1 |
| 11 | Frozen dough:effects of dough shape,water content and sheeting-molding condition显示文摘 | Gélinas P Deaudelin I Gressier M | 1995 | Cereal Foods World1995，40，3： | 1 |
| 12 | The Panton-Valentine leukocidin vaccine protects mice against lung and skin infections caused by Staphylococcus aureus USA300 显示文摘 | Brown EL Dumitrescu O Thomas D Badiou C Koers EM Choudhury P Vazquez V Etienne J Lina G Vandenesch F Bowden MG | 2009 | Clin Microbiol Infect2009，15，2： | 1 |
| 13 | Bakerr's yeast mitochondria,gassing power and freeze-thaw tolerance in dough显示文摘 | P Gé linas L Savoie N Rodrigue | 1996 | FoodMicrobiology1996，13，： | 1 |
| 14 | Drying kinetics of whole durum wheat pasta according to temperature and relative humidity显示文摘 | Villeneuve S G?linas P | 2007 | Swiss Society of Food Science and Technology2007，40，： | 1 |
| 15 | Recommendation systems with complex con- straints: A course recommendation perspective 显示文摘 | PARAMESWARAN A VENETIS P GARCIA- MO- LINA H | 2011 | ACM Transactions on Information Systems2011，29，4： | 1 |
| 16 | Flow injection spectrophotometric determination of free and total sulfite in wines based on the induced oxidation of manganese(II)显示文摘 | Lina R Silva G N P Silva C S | 1998 | Anal Lett1998，31，13： | 1 |
| 17 | The Properties of Ti-doped ZnO Films Deposited by Simultaneous RF and DC Magnetron Sputtering显示文摘 | Lina S S Huangga J L Sajgalik P | 2005 | Surf Coat Technol2005，191，： | 1 |
| 18 | Analysis of the geneticvariability of genes encoding the RNA III-activating compo-nents agr and TRAP in a population of Staphylococcus aureusstrains isolated from cows with mastitis显示文摘 | Gilot P Lina G Cochard T | 2002 | J Clin Microbiol2002，40，11： | 1 |
| 19 | Current perspectives on milk hypersensitivity显示文摘 | LEEA P LINA L ESA - MATTI L | 1999 | Trenda in Food Science and Technology1999，10，： | 1 |
| 20 | Production of aroma compounds by Geotrichum candidum on waste bread crumb显示文摘 | P Daigle P Gélinas D Leblanc A Morin | 1999 | Food Microbiology1999，，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员