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	题名	作者	年代	出处	被引量
1	Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury.	Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell	2012	World Journal of Gastroenterology2012，18，15：	3
2	Atmospheric transport and wet deposition of ammonium in North Carolina 显示文摘	Walker J T Aneja V P Dickey D A	2000	Atmospheric Environment2000，34，20：	1
3	Grid: a service-oriented model for the Semantic Grid显示文摘	Li M A Santen P V Walker D W	2004	Future Generation Computer Systems2004，20，：	1
4	Synthesis and size control of gold nanoparticles stabilized by poly(methyl- phenylphosphazene)显示文摘	Walker C H John J V S Wisian Neilson P	2001	J Am Chem Soc2001，123，16：	1
5	Viral disease emergence in shrimp aquaculture:Origins,impact and the effectiveness of health management strategies显示文摘	WALKER P J MONAN C V	2009	Reviews in aouacultur2009，1，2：	1
6	Genetic variation in cyclooxygenase 1:effects on response to aspirin显示文摘	Halushka M K Walker L P Halushka P V	2003	Clin Pharmacol Ther2003，73，1：	1
7	The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘	International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M	2010	Science2010，330，6010：	1
8	Investigation of the child with an acutemetabolic disorder显示文摘	Cook P Walker V	2011	J Clin Pathol2011，64，3：	1
9	A theoretical model of a plant anfifreeze protein from Lolium perenne显示文摘	Kuiper M J Davies P L Walker V K	2001	Biophys J2001，81，6：	1
10	Schizophrenia and bipolar disorder are distinguished mainly by differences in neurodevelopment 显示文摘	Walker J Curtis V Shaw P	2002	Neurotox Res2002，4，56：	1
11	Roniviridae Virus Taxonomy Ⅷth Report of the ICTV Fauquet C M Mayo M A Maniloff J Desselberger U and Ball L A eds显示文摘	Walker P J Bonami J R Boonsaeng V	2004	Elsevier Academic Press London2004，，：	1
12	Subchronic oral toxicity testing in rats with a liquid hand-dishwashing detergent containing anionic suractants 显示文摘	Scaiheur V Maurer J K Walker A P	1986	Chem Toxi1986，24，2：	1
13	Oxidant mechanisms in gentamicin nephrotoxicity 显示文摘	Walker P D Barri Y Shah S V	1999	Rert Fail1999，21，34：	1
14	Trimethylamine oxide counteracts effects of hydrostatic pressure on proteins of deep-sea teleosts 显示文摘	Yancey P H Fyfe-Johnson A L Kelly R H Walker V P Anfi6n M T	2001	The Journal of Experimental Zoology2001，289，3：	1
15	Investigation of the child with an acute metabolic disorder显示文摘	Cook P Walker V		0，，03：	1
16	Atmospheric transport and wet deposition of ammonium in North Carolina显示文摘	Walker J T Aneja V P Dickey D A	2000	Atmos Envi- ron2000，34，20：	1
17	Fever with Thrombocytopenia associated with a novel bunyavirus in China显示文摘	Yu X J Liang M F Zhang S Y Liu Y Li J D Sun Y L Zhang L H Zhang Q F Popov V L Li C Qu J Li Q Zhang Y P Hai R Wu W Wang Q Zhan F X Wang X J Kan B Wang SW Wan K L Jing H Q Lu J X Yin W W Zhou H Guan X H Liu J F Bi Z Q Liu G H Ren J Wang H Zhao Z Song J D He J R Wan T Zhang J S Fu X P Sun L N Dong X P Feng Z J Yang W Z Hong T Zhang Y Walker D H Wang Y Li D X	2011	N Engl J Med2011，364，16：	1
18	Fever with thrombocytopenia associated with a novel bunyavirus in China显示文摘	Yu X J Liang M F Zhang S Y Liu Y Li J D Sun Y L Zhang L Zhang Q F Popov V L Li C Qu J Li Q Zhang Y P Hai R Wu W Wang Q Zhan F X Wang X J Kan B Wang S W Wan K L Jing H Q Lu J X Yin W W Zhou H Guan X H Liu J F Bi Z Q Liu G H Ren J Wang H Zhao Z Song J D He J R Wan T Zhang J S Fu X P Sun L N Dong X P Feng Z J Yang W Z Hong T Zhang Y Walker D H Wang Y Li D X	2011	N Engl J Med2011，364，：	1
19	Grid:a Service-oriented Model for the Semantic Grid显示文摘	Li M A Santen P V Walker D W	2004	Future Generation Computer Systems2004，，20：	1
20	Atmospheric transport and wet deposition of ammonium in North Carolina 显示文摘	Walker J T Aneja V P Dickey D A	2000	Atmospheric Enviroument2000，34，20：	1

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