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| 1 | Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis显示文摘Hepatic encephalopathy(HE)is a common and serious neuropsychiatric complication of cirrhosis,acute liver failure,and porto-systemic shunting.HE largely contributes to the morbidity of patients with liver disease,severely affecting the quality of life of both patients and their relatives and being associated with poor prognosis.Its presentation is largely variable,manifesting with a broad spectrum of cognitive abnormalities ranging from subtle cognitive impairment to coma.The pathogenesis of HE is complex and has historically been linked with hyperammonemia.However,in the last years,it has become evident that the interplay of multiple actors,such as intestinal dysbiosis,gut hyperpermeability,and neuroinflammation,is of crucial importance in its genesis.Therefore,HE can be considered a result of a dysregulated gut-liverbrain axis function,where cognitive impairment can be reversed or prevented by the beneficial effects induced by“gut-centric”therapies,such as non-absorbable disaccharides,non-absorbable antibiotics,probiotics,prebiotics,and fecal microbiota transplantation.In this context dietary modifications,by modulating the intestinal milieu,can also provide significant benefit to cirrhotic patients with HE.This review will provide a comprehensive insight into the mechanisms responsible for gut-liver-brain axis dysregulation leading to HE in cirrhosis.Furthermore,it will explore the currently available therapies and the most promising future treatments for the management of patients with HE,with a special focus on the dietary approach. | Daniela Campion Ilaria Giovo Paola Ponzo Giorgio M Saracco Federico Balzola Carlo Alessandria | 2019 | World Journal of Hepatology2019，11，6： | 8 |
| 2 | Relationship between Crohn’s disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients显示文摘AIM: To study the association between Crohn’s disease (CD), Mycobacterium avium subspecies paratubercu- losis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sar dinian patients with CD and controls. METHODS: Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written con sent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to cal culate odds ratios (OR) for the associations among CD presence of MAP, and 6 loci described above. RESULTS: For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated withboth NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. CONCLUSION: Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of ge- netic, infectious, and immunologic factors in the etiology of CD is complex. | Leonardo A Sechi Maria Gazouli Lee E Sieswerda Paola Molicotti Niyaz Ahmed John Ikonomopoulos Antonio M Scanu Daniela Paccagnini Stefania Zanetti | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 3 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 5 | Heavy metal immobilization by chemical amendments in a polluted soil and influence on white lupin growth显示文摘 | Paola C Laura S Pietro M | 2005 | Chemosphere2005，60，： | 1 |
| 6 | Low plateletalpha2beta1 levels in type I von Willebrand disease correlate withimpaired platelet function in a high shear stress system显示文摘 | Di Paola J Federici A B Mannucci P M | 1999 | Blood1999，93，11： | 1 |
| 7 | Pedal-plantar loop technique for a challenging below-the-knee chronic total occlusion : a novel approach to percutaneous revascularization in critical lower limb ischemia显示文摘 | Fusaro M Dalla Paola L Biondi-Zoccai G | 2007 | J Invasive Cardiol2007，19，2： | 1 |
| 8 | Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa显示文摘 | De Filippo C Cavalieri D Di Paola M | | 0，，： | 1 |
| 9 | Binding of Co(II) and Cu(II) cations to chemically modified wool fibres: an IR investigation 显示文摘 | Paola T Patrizia M Giuliano F | 2003 | J Mol Struct2003，，650： | 1 |
| 10 | Digital simulation of wind field velocity 显示文摘 | Di Paola M | 1998 | Journal of Wind Engineering and Industrial Aerodynamics1998，7476，1： | 1 |
| 11 | Phylogenetic analysis of partial S1 and N gene sequences of infectious bronchitis virus isolates from Italy revealed genetic diversity and recombination显示文摘 | YURY A B GIOVANNI T PAOLA M | 2007 | Virus Genes2007，35，： | 1 |
| 12 | Highly active photocatalytic TiO2 powders obtained by thermohydrolysis of TiCl4 in water 显示文摘 | Paola A D Bellardita M Ceccato R | 2009 | JPhy Chem C2009，113，15： | 1 |
| 13 | Pedal -plantar loop tech- nique for a challenging below - the - knee chronic total occlusion : a no- vel approach to percutaneous revascularization in critical lower limb is- chemia 显示文摘 | Fusaro M Dalla Paola L Biondi -Zoccai G | 2007 | J Invasive Cardio12007，19，2： | 1 |
| 14 | Photocatalytic ac- tivity of nanocrystalline TiO2 (brookite, rutile and brookite- based) powders prepared by thermohydrolysis of TIC14 in a- queous chloride solutions 显示文摘 | Di Paola A Cufalo G Addamo M | 2008 | Colloids and Surfaces A: Physicochem Eng Aspects2008，317，13： | 1 |
| 15 | Photodegradation of lincomycin in aqueous solution显示文摘 | Di Paola A Addamo M Augugliaro V García-López E Loddo V Marcì G Palmisano L | | 0，，： | 1 |
| 16 | Chemical analysis and quality control of Gink- go biloba leaves, extracts, and phytopharmaceuticals 显示文摘 | Teris A B Paola M | 2009 | Chroma- tog A2009，1216，11： | 1 |
| 17 | Nonhematopoietic eryth-ropoietin derivatives prevent motoneuron degeneration in vitro and in vivo显示文摘 | Mennini T De Paola M Bigini P | 2006 | Mol Med2006，12，78： | 1 |
| 18 | Solubilization and stabilization of β-carotene in niosomes:delivery to cultured cells显示文摘 | PAOLA P RITA M SONIA T | 2006 | Chem Physics Lipids2006，139，： | 1 |
| 19 | The regulation framework of biosimilar in the European Union 显示文摘 | Paola M Paolo R | 2012 | Drug Discovery Today2012，，17： | 1 |
| 20 | Iron metabolism in thalassemia and sickle cell disease显示文摘 | Raffaella M Paola T Matteo P | 2009 | Medit J Hemat Dis2009，1，： | 1 |
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