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| 1 | Recruitment maneuvers in acute respiratory distress syndrome: The safe way is the best way显示文摘Acute respiratory distress syndrome(ARDS) represents a serious problem in critically ill patients and is associated with in-hospital mortality rates of 33%-52%. Recruitment maneuvers(RMs) are a simple, low-cost, feasible intervention that can be performed at the bedside in patients with ARDS. RMs are characterized by the application of airway pressure to increase transpulmonary pressure transiently. Once non-aerated lung units are reopened, improvements are observed in respiratory system mechanics, alveolar reaeration on computed tomography, and improvements in gas exchange(functional recruitment). However, the reopening process could lead to vascular compression, which can be associated with overinflation, and gas exchange may not improve as expected(anatomical recruitment). The purpose of this review was to discuss the effects of different RM strategies- sustained inflation, intermittent sighs, and stepwise increases of positive end-expiratory pressure(PEEP) and/or airway inspiratory pressure- on the following parameters: hemodynamics, oxygenation, barotrauma episodes, and lung recruitability through physiological variables and imaging techniques. RMs and PEEP titration are interdependent events for the success of ventilatory management. PEEP should be adjusted on the basis of respiratory system mechanics and oxygenation. Recent systematic reviews and meta-analyses suggest that RMs are associated with lower mortality in patients with ARDS. However, the optimal RM method(i.e., that providing the best balance of benefit and harm) and the effects of RMs on clinical outcome are still under discussion, and further evidence is needed. | Raquel S Santos Pedro L Silva Paolo Pelosi Patricia RM Rocco | 2015 | World Journal of Critical Care Medicine2015，4，4： | 19 |
| 2 | Comparative study of laparoscopic vs open gastrectomy in gastric cancer management显示文摘AIM:To compare long-term results of gastric cancer patients undergoing laparoscopic and open gastrec-tomy in a single unit.METHODS:From February 2000 to September 2004,all patients with adenocarcinoma of the stomach were assessed to entry in this longitudinal prospective non-randomized trial.Primary endpoint was cancer-related survival and secondary endpoints were overall survival,evaluation of surgical complications and mortality.RESULTS:Fifty-eight patients were enrolled.Forty-seven patients were followed-up(range 11-103,me-dian 38 mo).Four patients were lost at follow up.Twenty-two patients underwent a laparoscopic gastric surgery(LGS)and 25 had a standard open procedure(OGS).No statistical difference was found between the two groups in terms of 5 years cancer-related mortality rate(50% vs 52%,P = 1),and 5 years overall mortal-ity rate(54.5% vs 56%,P = 1).Accordingly,cancer-related and overall survival probability by Kaplan-Meier method showed comparable results(P = 0.81 and P = 0.83,respectively).We found no differences in surgical complications in the 2 groups.There was no conversion to open surgery in this series.CONCLUSION:LGS is as effective as OGS in the man-agement of advanced gastric cancer.However LGS can-not be recommended routinely over OGS for the treat-ment of advanced gastric cancer. | Giuseppe S Sica Edoardo Iaculli Livia Biancone Sara Di Carlo Rosa Scaramuzzo Cristina Fiorani Paolo Gentileschi Achille L Gas-pari | 2011 | World Journal of Gastroenterology2011，17，41： | 9 |
| 3 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 4 | Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials显示文摘 | Guglielmo Ronco Joakim Dillner K Miriam Elfstr?m Sara Tunesi Peter J F Snijders Marc Arbyn Henry Kitchener Nereo Segnan Clare Gilham Paolo Giorgi-Rossi Johannes Berkhof Julian Peto Chris J L M Meijer | 2013 | The Lancet2013，，： | 3 |
| 5 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 6 | Female urinary incontinence during pregnancy and after delivery: Clinical impact and contributing factors显示文摘Urinary incontinence(UI) is a common condition affecting adult women of all ages and it could have a negative infl uence on quality of life. The etiology of UI is multifactorial, but some of the most important risk factors are obesity and ageing, as well as adverse obstetric events. Pregnancy and delivery per se have been implicated in the etiology of UI. Although several studies have demonstrated a direct association between UI and vaginal delivery in short, medium and long-term, the role of childbirth on the risk of UI remains controversial. The mechanical strain during delivery may induce injuries to the muscle, connective and neural structures. Vaginal birth can be associated with relaxation or disruption of fascial and ligamentous supports of pelvic organs. Parity, instrumental delivery, prolonged labor and increased birth weights have always been considered risk factors for pelvic floor injury. Also genetic factors have been recently raised up but still there are not appropriate guidelines or measures to reduce signifi cantly the incidence of UI. The role of pelvic fl oor muscle training(PFMT) in the prevention and treatment of UI is still unclear. However, PFMT seems to be useful when supervised training is conducted and it could be incorporated as a routine part of women's exercise programmes during pregnancy and after childbirth. | Paolo Mannella Giulia Palla Gonzalo Pérez-Roncero María T López-Baena Faustino R Pérez-López | 2013 | World Journal of Obstetrics and Gynecology2013，2，4： | 2 |
| 7 | Dialysate and replacement fluid composition for CRRT显示文摘 | AUCELLA F DI PAOLO S GESUALDO L | 2007 | Contrib Neph- rol2007，156，： | 1 |
| 8 | Fenhexamid Residues in Grapes and Wine显示文摘 | PAOLO C ALBERTO A VINCENZO L | 2001 | Food Additives and Contaminants2001，18，7： | 1 |
| 9 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 10 | Low-density lipoproteins enhance transforming growth factor-beta 1 (TGF-beta 1) and monocyte chemotactic protein-1 (MCP-1)expression induce cyclosporin in human mesangial cells 显示文摘 | Paolo S Grandaliano G Gesual L Ranieri E Schena FP | 1999 | Clin Exp Immunol1999，117，2： | 1 |
| 11 | Design criteria for mode size optimization in diodepumped solid-state lasers 显示文摘 | PAOLO L | 1991 | IEEE J Q E1991，27，10： | 1 |
| 12 | In vivo single branch axotomy in- duces GAP - 43 - dependent sprouting and synaptic remodeling in cerebellarcortex 显示文摘 | Anna L Allegra M Paolo C | 2013 | PNAS2013，5，10： | 1 |
| 13 | AC/DC/AC PWM converter with reduced energy storage in the link 显示文摘 | Malesani L Rossetto L Tenti Paolo | 1995 | IEEE Trans IA1995，27，2： | 1 |
| 14 | A Planning and Management Infrastructure for Large,Complex,Distributed Projects:Beyond ERP and SCM显示文摘 | Kovács George L Paganelli Paolo | 2003 | Computers in Industry2003，51，2： | 1 |
| 15 | Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens显示文摘 | Giuseppe Zamboni Jutta Lüttges Paola Capelli Luca Frulloni Giorgio Cavallini Paolo Pederzoli Alexander Leins Daniel Longnecker Günter Kl?ppel | 2004 | Virchows Archiv2004，，6： | 1 |
| 16 | A Comparison of Three Methods for Principal Component Analysis of Fuzzy Interval Data显示文摘 | Paolo Giordani Henk A L Kiers | 2006 | Com- putational Statistics & Data Analysis2006，，5： | 1 |
| 17 | US-Guided percuta- neous radiofrequency thermal 'ablation for the treatment of solid benign hyperfunctioning or compressive thyroid nodules 显示文摘 | Deandrea M Paolo L Edoardo B | 2008 | Ultrasound Med Bio2008，34，： | 1 |
| 18 | Co-operative production plan- ning for small and medium-sized enterprises显示文摘 | Istvan T Gyorgy L K Paolo P | 2000 | International Journal of Production Economics2000，64，1： | 1 |
| 19 | High glucuse concentration induces the overexpression of transfotruing growth factor-beta through the activation of platelet-derived growth factor loop in human mesangial cells 显示文摘 | Di Paolo S Gesualdo L Ranieri E | 1996 | Am J Pathology1996，149，6： | 1 |
| 20 | Simulation of people evacuation in the event of a road tunnel Fire 显示文摘 | Ciro C Paolo C Maria L D G Mafia G M | 2012 | Social and Behavioral Sciences2012，53，： | 1 |
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