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| 1 | Mutants, Overexpressors, and Interactors of Arabidopsis Plastocyanin Isoforms: Revised Roles of Plastocyanin in Photosynthetic Electron Flow and Thylakoid Redox State显示文摘二相应 plastocyanin isoforms 被基因 PETE1 和 PETE2 编码为 Arabidopsis thaliana 的原子染色体。PETE2 抄本被表示在更加高水平和 PETE2 蛋白质是更丰富的 isoform。在 PETE 基因的空变化导致了植物,指明的 pete1 和 pete2,与减少的 plastocyanin 内容。尽管有在超过 90% 减少 plastocyanin 层次,而 pete1 大美人种,然而,它的自己上的一个 pete2 0 变化仅仅稍微影响光合作用和生长的率,与大约 6080% 野类型的 plastocyanin 水平,没显示出任何改变。因此, plastocyanin 集中不在最佳的生长条件下面为光合的电子流动正在限制,也许为蛋白质暗示另外的可能的生理的角色。确实, plastocyanin 以前被建议了在 thylakoid 氧化还原作用反应与细胞色素 c6A (Cyt c6A ) 合作,但是我们不为在二蛋白质之间的一个物理相互作用发现证据,用在酵母的相互作用试金。我们在酵母相互作用试金观察了 Cyt c6A 的 homodimerization,而且 Cyt c6A homodimers 没能与 plastocyanin 交往。而且, atc6-1 pete1 的 phenotypic 分析和 atc6-1 pete2 加倍异种,每缺乏的 Cyt c6A 并且二编码 plastocyanin 基因之一,没能揭示任何基因相互作用。在 pete1 pete2 的 PETE1 或 PETE2 的 Overexpression 在实质上野类型的光合的性能的两倍猛烈变异的背景结果,排除二 plastocyanin isoforms 能在 thylakoid 有不同函数的可能性电子流动。 | Paolo Pesaresi Michael Scharfenberg Martin Weigel Irene Granlund Wolfgang R Schroder Giovanni Finazzi Fabrice Rappaport Simona Masiero Antonella Furini Peter Jahns Dario Leister | 2009 | Molecular Plant2009，2，2： | 7 |
| 2 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 3 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 4 | Female urinary incontinence during pregnancy and after delivery: Clinical impact and contributing factors显示文摘Urinary incontinence(UI) is a common condition affecting adult women of all ages and it could have a negative infl uence on quality of life. The etiology of UI is multifactorial, but some of the most important risk factors are obesity and ageing, as well as adverse obstetric events. Pregnancy and delivery per se have been implicated in the etiology of UI. Although several studies have demonstrated a direct association between UI and vaginal delivery in short, medium and long-term, the role of childbirth on the risk of UI remains controversial. The mechanical strain during delivery may induce injuries to the muscle, connective and neural structures. Vaginal birth can be associated with relaxation or disruption of fascial and ligamentous supports of pelvic organs. Parity, instrumental delivery, prolonged labor and increased birth weights have always been considered risk factors for pelvic floor injury. Also genetic factors have been recently raised up but still there are not appropriate guidelines or measures to reduce signifi cantly the incidence of UI. The role of pelvic fl oor muscle training(PFMT) in the prevention and treatment of UI is still unclear. However, PFMT seems to be useful when supervised training is conducted and it could be incorporated as a routine part of women's exercise programmes during pregnancy and after childbirth. | Paolo Mannella Giulia Palla Gonzalo Pérez-Roncero María T López-Baena Faustino R Pérez-López | 2013 | World Journal of Obstetrics and Gynecology2013，2，4： | 2 |
| 5 | Issues on soot removal from exhaust gases by means of radial flow ceramic traps显示文摘 | PAOLO C VINCENZO P PAOLA R | 2005 | Chem Eng Sci2005，60，6： | 1 |
| 6 | PCNA in the testis of the frog, Rana esculenta; A molecular marker of the mitotic testicular epithelium proliferation显示文摘 | Paolo C Franco R Fulgione D | 2000 | General and Comparative Endocrinology2000，119，： | 1 |
| 7 | Thermal analysis of biomass and corresponding pyrolysis products 显示文摘 | PAOLO G LEANDRO R LUCIANA A | 1996 | Fuel1996，75，5： | 1 |
| 8 | Recombinant human, active site-blocked factor Ⅶa reduces infarct size and no-reflow phenomenon in rabbits显示文摘 | Paolo G Massimo R Plinio C | 2000 | Am J Physiol Heart Circ Physiol2000，278，： | 1 |
| 9 | Formamide hydrolysis investigated by multiple-steering ab Initio molecular dynamics显示文摘 | Simone R Paolo C | 2004 | J Phys Chem B2004，108，1： | 1 |
| 10 | The regulation framework of biosimilar in the European Union 显示文摘 | Paola M Paolo R | 2012 | Drug Discovery Today2012，，17： | 1 |
| 11 | The IFAST model,a novel parallel nonlinear EEG analysis technique,distinguishes mild cognitive impairment and Alzheimer's disease patients with high degree of accuracy显示文摘 | Massimo B Paolo R Claudio B | 2007 | Artif Intell Med2007，40，2： | 1 |
| 12 | Surgical treatment of Graves disease: subtotal or total thyroidectomy? 显示文摘 | Paolo M Paolo V Teresa R | 1996 | Surgery1996，120，6： | 1 |
| 13 | Isoprostanes: markers and mediators of oxidative stress显示文摘 | Paolo M Peter JB Jackson R | 2004 | The FASEB Journal2004，18，12： | 1 |
| 14 | Biomarkers in pediatric heart failure: their role in diagnosis and evaluating disease progression 显示文摘 | Paul F Kantor Paolo R | 2011 | Prog Pediatr Cardiol2011，31，： | 1 |
| 15 | Phenotypic characterization of lactic acid bacteria from sourdoughs for Altamura bread produced in Apulia (Southern Italy)显示文摘 | Annamaria R Eugenio P Paolo P | 2005 | Food Microbiology2005，98，： | 1 |
| 16 | Relationship between 5 fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients显示文摘 | Di Paolo A Danesi R Falcone A | 2001 | Ann Oncol2001，12，9： | 1 |
| 17 | Circulating Anti ~ PLA2R Au-toantibodies to Monitor Immunological Activity in MembranousNephropathy显示文摘 | Paolo C Piero R Giuseppe R | 2011 | J Am Soc Nephrol2011，22，： | 1 |
| 18 | Regulation of the p73 protein stability and degradation显示文摘 | Andrew O Mario R Paolo S | 2005 | Biochemical and Biophysical Research Communications2005，331，3： | 1 |
| 19 | Urban mobility and urban form: The social and environment costs of different patterns of urban expansion 显示文摘 | Roberto C Maria C G Paolo R | 2002 | Ecological Economics2002，40，2： | 1 |
| 20 | Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort显示文摘 | Sabrina Schlesinger Krasimira Aleksandrova Tobias Pischon Veronika Fedirko Mazda Jenab Elisabeth Trepo Paolo Boffetta Christina C. Dahm Kim Overvad Anne Tj?nneland Jytte Halkj?r Guy Fagherazzi Marie‐Christine Boutron‐Ruault Franck Carbonnel Rudolf Kaaks A | 2012 | Int J Cancer2012，，3： | 1 |
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