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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Lecithin : cholesterol acyltransferase deficiency increases atherceclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice 显示文摘 | Furbee JW Jr Sawyer JK Parks JS | 2002 | J Biol Chem2002，277，5： | 1 |
| 3 | Contemparary management of acute mesenterie ischemia: factors associated with survival 显示文摘 | Park WM Cloviezki P Cherry KJ Jr | 2002 | Vasc Surg2002，35，： | 1 |
| 4 | Bcl-2, a novel regulator of apoptosis显示文摘 | PARK JR HOCKENBERY DM | 1996 | J Cell Biochem1996，60，1： | 1 |
| 5 | Neuroblastoma:biology,prognosis,and treatment显示文摘 | Park JR Eggert A Caron H | 2010 | Hematol Oncol Clin North Am2010，24，1： | 1 |
| 6 | Comparisons of three automated systems for genomic DNA extraction in a clinical diagnostic labo ratory 显示文摘 | Lee J H Park Y Choi JR | 2010 | Yonsei Med J2010，51，1： | 1 |
| 7 | Neuroblastoma : Biology, prognsis, and treatment显示文摘 | Park JR Eggert A Caron H | 2008 | Pediatr Clin N Am2008，55，1： | 1 |
| 8 | A new atrial septostomy technique显示文摘 | Park SC Zuberbuhler JR Neches WH | 1975 | Cathet Cardivasc Diagn1975，1，2： | 1 |
| 9 | Expression of nerve growth factor and vascular endothelial growth factor in the inferior alveolar nerve after distraction osteogenesis显示文摘 | Park BW Kim JR Lee JH | 2006 | Int J Oral Maxillofac Surg2006，35，： | 1 |
| 10 | Neuroblastoma: Biology, prognosis, and treatment显示文摘 | Park JR Eggert A Caron H | 2008 | Pediatr Clin North Am2008，55，1： | 1 |
| 11 | Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities 显示文摘 | Schloss PD Westcott SL Ryabin T Hall JR Hartmann M Hollister EB Lesniewski RA Oakley BB Parks DH Robinson CJ Sahl JW Stres B Thallinger GG Van Horn DJ Weber CF | 2009 | Appl Environ Microbiol2009，75，23： | 1 |
| 12 | Isolation and characterization of canine umbilical cord blood-derived mesenchymal stem cells显示文摘 | Seo MS Jeong YH Park JR | 2009 | J Vet Sci2009，10，3： | 1 |
| 13 | Mutagenic potentials of fumonisin contaminated corn following ammonia decontamination procedure显示文摘 | Park DL Rua SM Jr Mirocha CJ | 1992 | Mycopathologia1992，117，12： | 1 |
| 14 | Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion显示文摘 | Park K Robinson JR | 1984 | Int J Pharm1984，19，： | 1 |
| 15 | The long-term result of total repair for tetralogy of Fallot显示文摘 | Park CS Lee JR Lim HG | | 0，，03： | 1 |
| 16 | The long-term result of total repair for tetralogy of Fallot显示文摘 | Park CS Lee JR Lim HG | 2010 | Eur J Cardiothorac Surg2010，38，： | 1 |
| 17 | Serologic and molecular detection of Ehrlichia chaffeensis and Anaplasma phagocytophila (human granulocytic ehrlichiosis agent) in Korean patients显示文摘 | Heo E J Park JH Koo JR | 2002 | J Clin Microbiol2002，40，8： | 1 |
| 18 | Akt as a mediator of secretory phospholipase A2 receptor-involved inducible nitric oxide synthase expression 显示文摘 | Park DW Kim JR Kim SY | 2003 | J Immunol2003，170，4： | 1 |
| 19 | Phylogenetic, structural and functional characteristics of the Na--K--Cl cotransporter family显示文摘 | Park JH Saier MH Jr | 1996 | J Membrane Biol1996，149，： | 1 |
| 20 | Nutritionally directed compen-satory growth enhances heifer development and lacta- tion potential显示文摘 | Ford J A Jr Park C S | 2001 | Dairy Sci2001，84，7： | 1 |
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