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| 1 | Detection of Stage I nasopharyngeal carcinoma by serologicscreening and clinical examination显示文摘In a prospective study, 42 048 adults residing in Zhongshan City, Guangdong, China, were followed for 16 years, and 171 of them developed nasopharyngeal carcinoma (NPC). Although Epstein-Barr virus (EBV) antibody levels of the cohort fluctuated, the antibody levels of 93% of the patients with NPC were raised and maintained at high levels for up to 10 years prior to diagnosis. This suggests that the serologic window affords an opportunity to monitor tumor progression during the preclinical stage of NPC development, facilitating early NPC detection. We reviewed the clinical records of the 171 patients with NPC in the prospective study to assess the efficacy of early NPC detection by serologic screening and clinical examination. Of the 171 patients, 51 had Stage I tumor (44 were among the 73 patients detected by clinical examination and 7 were among the 98 patients presented to outpatient department). Initial serologic screening predicted 58 (95.1%) of the 61 patients detected within 2 years. The risk of the screened population (58/3093) raised 13 times relative to cohort (61/42 048) during this period. Clinical examination detected all the 58 predicted cases, and 35 (60.3%) of which were diagnosed with Stage I tumor. The serologic prediction rate fell to 33.6% (37/110) 2 to 16 years after screening. The proportion of cases detected by clinical examination fell to 40.5% (15/37). The proportion of Stage I tumors among the cases detected by clinical examination during both periods remained at about 60%. We concluded that early detection of NPC can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect tumors before the symptoms develop. | Ming-Fang Ji Yuan-Long Yu Wei-Ming Cheng Yong-Sheng Zong Park Sze-Park Ng Daniel Tsin-Tien Chua Mun-Hon Ng | 2011 | Chinese Journal of Cancer2011，30，2： | 3 |
| 2 | A high-efficiency Cre/ loxP-based system for construction of adenov iral vector显示文摘 | Ng P Parks RJ Cummings DT | 1999 | Hum Gene Ther1999，10，16： | 1 |
| 3 | Non small cell lung cancer(NSCLC): Are elderly patients being under- treated?Journal of Clinical Oncology, 2004 ASCO Annum Meeting Proceedings (Post - Meeting Edition) 显示文摘 | R Ng R De Boer A Park | 2004 | 22(July 15 Supplement): 71182004，22，15： | 1 |
| 4 | Antioxdative effect of chitosan on chronic carachloride induced hepatic injury in rats显示文摘 | Jeon TI Hwang SG Park NG | | 0，，01： | 1 |
| 5 | Antioxidative effect of chitosan on chronic carbon tetrachloride induced hepatic injury in rats显示文摘 | JEON TI HWANG SG PARK NG | 2003 | Toxicology2003，187，1： | 1 |
| 6 | A high-efficiency Cre/IoxP-based system for construction of adenoviral vectors 显示文摘 | Ng P Parks RJ Cummings DT | 1999 | Hum Gene Ther1999，10，16： | 1 |
| 7 | Low power radiofrequency ablation for symptomatic microcystic lymphatic malformation of the tongue显示文摘 | Ryu NG Park SK Jeong HS | 2008 | Int J Pediatr Otorhinolaryngol2008，72，11： | 1 |
| 8 | Extraction behaviors of caffeine and chlorophyl s in supercritical decaffeination of green tea leaves显示文摘 | Park HS Im NG Kim KH | | 0，，01： | 1 |
| 9 | Antioxidative effect of chitosan on chronic carbon tetrachloride induced hepatic injury in rats显示文摘 | Jeon TI Hwang SG Park NG | 2003 | Toxicology2003，187，1： | 1 |
| 10 | Antioxidative effect of chitosan on chronic carbon tetrachloride induced hepatic injury in rats显示文摘 | Jeon TI Hwang SG Park NG | 2003 | Toxicology2003，187，1： | 1 |
| 11 | Synthesis and electrochemical properties of V2O5 intercalated with binary polymers 显示文摘 | Park NG RyuKS ParkYJ etal | 2002 | J Power Sources2002，103，2： | 1 |
| 12 | Determination of nanoparticle vehicle unpackaging by MR imaging of a T(2) magnetic relaxation switch显示文摘 | Park IK Ng CP Wang J | 2008 | Biomaterials2008，29，6： | 1 |
| 13 | Proteomic analysis and molecular characterization of tissue ferritin light chain in hepatocellular carcinoma显示文摘 | Park KS Kim H Kim NG | 2002 | Hepatology2002，35，6： | 1 |
| 14 | The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc显示文摘 | Park KS Lee NG Lee KH | 2003 | Am J Physiol Gastrointest Liver Physiol2003，285，6： | 1 |
| 15 | A high -efficiency Cre/loxP-based system for construction of adenoviral vectors显示文摘 | Parks RJ Cummings DT | 1999 | Hum Gene Ther1999，10，16： | 1 |
| 16 | A Study by Electrical Impedance and Optical Modulation Tech- niques显示文摘 | J Van de Lagemaat NG Park A J Frank | 2000 | Phys Chem B2000，104，： | 1 |
| 17 | 显示文摘 | Chung NG Jeong DC Park S J | 2004 | Int J Hematol2004，80，4： | 1 |
| 18 | Implication of genetic variants near TCF7L2,SLC3OA8,HHEX,CDKALI,CDKN2A/B,IGF2BP2,and FTO in type 2 diabetes and obesity in 6,719 Asians显示文摘 | Ng MC Park KS Oh B | 2008 | Diabetes2008，57，8： | 1 |
| 19 | An enhanced system for construction of adenoviral vectors by the two-plasmid rescue method显示文摘 | NG P PARKS R J CUMMINGS D T | 2000 | Hum Gene Ther2000，11，5： | 1 |
| 20 | A high-efficiency Cre/loxPbased system for construction of adenoviral vectors 显示文摘 | Ng P Parks RJ Cummings DT | 1999 | Hum Gene Ther1999，10，16： | 1 |
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