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| 1 | The short form of the SUR1 and its functional implications in the damaged brain显示文摘Sulfonylurea receptor(SUR) belongs to the adenosine 5′-triphosphate(ATP)-binding cassette(ABC) transporter family;however,SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the pore.Abcc8 and Abcc9 genes code for the proteins SUR1 and SUR2,respectively.The SUR1 transcript encodes a protein of 1582 amino acids with a mass around 140–177 k Da expressed in the pancreas,brain,heart,and other tissues.It is well known that SUR1 assembles with Kir6.2 and TRPM4 to establish K_(ATP) channels and non-selective cation channels,respectively.Abbc8 and 9 are alternatively spliced,and the resulting transcripts encode different isoforms of SUR1 and SUR2,which have been detected by different experimental strategies.Interestingly,the use of binding assays to sulfonylureas and Western blotting has allowed the detection of shorter forms of SUR(-65 k Da).Identity of the SUR1 variants has not been clarified,and some authors have suggested that the shorter forms are unspecific.However,immunoprecipitation assays have shown that SUR2 short forms are part of a functional channel even coexisting with the typical forms of the receptor in the heart.This evidence confirms that the structure of the short forms of the SURs is fully functional and does not lose the ability to interact with the channels.Since structural changes in short forms of SUR modify its affinity to ATP,regulation of its expression might represent an advantage in pathologies where ATP concentrations decrease and a therapeutic target to induce neuroprotection.Remarkably,the expression of SUR1 variants might be induced by conditions associated to the decrease of energetic substrates in the brain(e.g.during stroke and epilepsy).In this review,we want to contribute to the knowledge of SUR1 complexity by analyzing evidence that shows the existence of short SUR1 variants and its possible implications in brain function. | Iván Alquisiras-Burgos Javier Franco-Pérez Moisés Rubio-Osornio Penélope Aguilera | 2022 | Neural Regeneration Research2022，17，3： | 1 |
| 2 | Ultracompact,Low-Loss Directional Couplers on InP Based on Self-Imaging by Multimode Interference显示文摘 | Pennings E C M Deri R J Scherer A Bhat R Hayes T R Andreadakis N C Smit M K Soldano L B Hawkins R J | 1991 | Appl Phys Lett1991，59，： | 1 |
| 3 | Cardiopulmonary bypass support for emergency cesarean delivery in a patient with severe pulmonary hypertension显示文摘 | Penning S Thomas N Atwal D | 2001 | Am J Obstet Gynecol2001，184，2： | 1 |
| 4 | The Influence of Cr and N Additions on the Mechanical Properties of FeMnC Steels 显示文摘 | Bracke L Penning J Akdut N | 2007 | Metallurgical and Materials Transactions2007，38，3： | 1 |
| 5 | Light and short arc rubs in rotating machines: experimental tests and modeling显示文摘 | PEN'ACCHI P BACHSCHMID N TANZI E | 2009 | Mechanical Systems and Signal Processing2009，23，： | 1 |
| 6 | Implementing guidelines for cancer pain management: results of a randomized controlled clinical trial 显示文摘 | Du Pen s Du Pen AR Polixsar N | 1999 | J Clin Oncol1999，17，： | 1 |
| 7 | The Influence of Cr and N Additonson the Mechanical Properties of FeMnC Steel 显示文摘 | Bracke L Penning J Akdut N | 2007 | Metallurgical andMaterials Transactions A2007，38，： | 1 |
| 8 | High-Temperature Deformation Properties of Austenitic Fe-Mn Alloys 显示文摘 | Cabanas N Akdut N Penning J | 2006 | Metallurgical and Materials Transactions2006，37，11： | 1 |
| 9 | The influenee of eytoreduetivesurgery on reeurrenee - free interval and survival insmall - volume stage 111 epithelial ovariane eaneer 显示文摘 | Hoskins W J Bundy B N Thig Pen T | 1992 | Gynecol Oncol1992，47，： | 1 |
| 10 | Microwave-assisted hydrothermaI synthesis of nanozeolites with controllable size 显示文摘 | HU Y LILT C ZHANG Y H PEN N TANG Y | 2009 | Microporous Mesoporous Mater2009，119，13： | 1 |
| 11 | The lipopolysaccharide biosynthesis locus of Campylobacter jejuni 81116显示文摘 | Fry B N Korolik V Ten Brinke J A Pennings M T T Zalm R Teunis B J J Coloe P J Zeijst B A M | 1998 | Microbiol1998，144，： | 1 |
| 12 | Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases显示文摘 | Mehra N Penning M Maas J | 2006 | Clin Cancer Res2006，12，： | 1 |
| 13 | A method to make use of thermal infrared temperature and NDVI measurements to infer surface soil water content and fractional vegetation cover显示文摘 | Carlson T N Gillies R R Pen'y E M | 1994 | Remote Sensing Reviews1994，9，： | 1 |
| 14 | Differentiation of Lactococcus lactis subspecies lactis and subspecies cremoris Strains by Their Adaptive Response to Stresses显示文摘 | KIM W S PEN J and DUNN N W | 1999 | FEMS Microbiol Lett1999，171，： | 1 |
| 15 | Treatment with fixed thyroxine doses in pregnant women with subclinical hypothyroidism显示文摘 | Seoane Cruz I Penín lvarez M Luna Cano R | 2012 | Endocrinol Nutr2012，59，5： | 1 |
| 16 | Metformin reduces thyrotropin levels in obese,diabetic women with primary hypothyroidism on thyroxine replacement therapy显示文摘 | Isidro ML Penín MA Nemi6a R | | 0，，： | 1 |
| 17 | Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases 显示文摘 | Mehra N Penning M Maas J | 2006 | Clin Cancer Res2006，12，16： | 1 |
| 18 | Consumer Food Safety Risk Attitudes and Perceptions Over Time:The Case of BSE Crisis显示文摘 | Kalogeras N Pennings J M E Van Ittersun Koert | | 0，，： | 1 |
| 19 | Previous cycle cancellation due to poor follicular development as a predictor of ovarian response in cycles stimulated with gonadotrophin - releasing hormone agonist - gona- dotrophin treatment 显示文摘 | Pen N arrubia J Fabregues F Manau D | 2005 | Hum Reprod2005，20，3： | 1 |
| 20 | Comparison between high strength concrete and normal strength con crete subjected to high temperature显示文摘 | PEN Gaifei CHAN J K W | 1996 | Mater Struct1996，29，： | 1 |
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