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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 3 | Protein post-translational modifications and regulation of pluripotency in human stem cells显示文摘translational 以后修正(PTM ) 被知道是真核细胞的房间过去常多样化他们的蛋白质函数和动态地并列的他们的发信号网络的必要机制。在 PTM 的缺点被连接了到众多的发展混乱和人的疾病,强调在维持正常细胞的状态的 PTM 的重要性。包括胚胎的干细胞(hESCs ) 和导致的 pluripotent 干细胞(hiPSCs ) ,人的 pluripotent 干细胞(hPSCs ) 能够自强和区别进许多功能的体的房间;这些房间为生物医学的研究和临床的治疗的前进保持一条大诺言。在人的房间位于细胞的 pluripotency 下面的机制广泛地在过去的十年被探索了。除了获得从的知识的广阔数量基因并且在 hPSCs 的 transcriptional 研究,干细胞生物学领域里有很快成长的兴趣在蛋白质和 PTM 水平检验 pluripotency。这评论向在细胞的 pluripotency 的规定理解 PTM (glycosylation, phosphorylation, acetylation 和 methylation ) 的角色探讨最近的进步。 | Yu-Chieh Wang Suzanne E Peterson Jeanne F Loring | 2014 | Cell Research2014，24，2： | 3 |
| 4 | Behavioral effects of social challenges and genomic mechanisms of social priming: What's testosterone got to do with it?显示文摘 | Kimberly A. ROSVALL Mark E PETERSON | 2014 | Current Zoology2014，60，6： | 2 |
| 5 | 世界家庭医生组织(WONCA)研究论文摘要汇编——高度连续的全科医疗服务可降低患者医疗费用和住院率显示文摘目的连续性服务是全科医疗的基本特征之一,其可以降低医疗成本、改善医疗公平性、提高医疗服务质量。但目前以医学专业角度,包括利用联邦医疗质量支付项目,对全科医疗服务的连续性价值进行评估的研究较为缺乏。本研究采用常用的以全科医师视角评估全科医疗服务连续性的4项指标(特定照护者连续性指数、BiceBoxerman照护连续性指标、修订连续性指标、赫芬达尔指数),评估医保参保患者接受的全科医疗服务的连续性,并分析其与医疗费用和住院率的关系。方法数据来源于经6 551例全科医师诊治的1 448 952例医保参保患者的医保报销资料。采用上述4项指标对患者接受的全科医疗服务的连续性进行评估。将接受诊疗的每例患者评价的连续性得分加权平均后,得到该例医师的连续性得分。以患者特征、全科医师特征、农村服务范围建立模型。将患者花费的可被医保A&B(住院保险和补充性医保)报销的实际医疗费用取自然对数后,采用多元线性回归分析全科医疗服务连续性与医疗费用的关系。采用Logistic回归分析全科医疗服务连续性与住院率的关系。结果对4项指标的评估结果均显示,全科医疗服务连续性与医疗费用和住院率呈高度相关,相关系数为0.86~0.99,即高度连续的全科医疗服务可以降低患者的医疗费用和住院率。在调整患者特征和全科医师特征后,将Bice-Boxerman照护连续性得分5等分,得分最高组患者较最低组患者的医疗费用降低了14.1%[($8 092比$6 958,β=-0.151,95%CI(-0.186,-0.116)],住院率降低了16.1%[OR=0.839,95%CI(0.787,0.893)]。结论高度连续的全科医疗服务可以降低医疗费用和住院率。本研究采用的4项评估指标可能与联邦医疗质量支付项目一样有效,鉴于较高的医疗资源利用率有利于降低医疗费用,该4项指标也可以用来评估医疗资源的利用情况。 | 本刊编辑部 BAZEMORE A PETTERSON S PETERSON L E | 2019 | 中国全科医学2019，22，1： | 2 |
| 6 | Provisional stenting strategies:systematic overview and implications for clinical decision making显示文摘 | Cantor E J Peterson E D Popma J J | 2001 | J Am Coll Cardiol2001，36，： | 1 |
| 7 | Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice显示文摘 | Jenuth J P Peterson A C Shoubridge E A | 1997 | Nature Genetics1997，16，： | 1 |
| 8 | Understanding relationships among multiple ecosystem services显示文摘 | Bennett E M Peterson G D Gordon L J | 2009 | Ecol Let2009，，12： | 1 |
| 9 | Time-lapse crosswell seismic and VSP monitoring of injected COe in a brine aquifer 显示文摘 | Daley T M Myer L R Peterson J E | 2008 | Environmental Geology2008，54，8： | 1 |
| 10 | Low diagnostic yield of elective coronary angiography 显示文摘 | PATEL M R PETERSON E D DAI D | 2010 | N Engl J Med2010，362，10： | 1 |
| 11 | Isolation and characterization of a maize gene encoding chalcone flavonone isomerase显示文摘 | GROTEWOLD E PETERSON T | 1994 | Mol Gen Genet1994，242，1： | 1 |
| 12 | Degenerative marrow (modic) changes on cervical spine magnetic resonance imaging scans: preva- lence, inter- and intra-examiner reliability and linkto disc herniation 显示文摘 | Mann E Peterson CK Hodler J | 2011 | Spine (Phila Pa 1976)2011，36，： | 1 |
| 13 | Forest ecosystem process at the watershed scale: Basis for distributed simulation显示文摘 | Band L E Peterson D L Running S W etal | 1991 | Ecological Modelling1991，56，： | 1 |
| 14 | A Bayesian approach for multiple response surface optimization in the presence of noise variables显示文摘 | Castillo E D Peterson J J | 2004 | J Applied Statistics2004，31，3： | 1 |
| 15 | Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis显示文摘 | Rubenstein E B Peterson D E Schubert M | 2004 | Cancer2004，100，9： | 1 |
| 16 | Effect of neutral endopeptidase inhibition on myocardial ischemia/reperfusion injury : the role of kinins 显示文摘 | YANG X P LIU Y H PETERSON E | 1997 | Card Pharm1997，29，2： | 1 |
| 17 | Nonstoichiometry and Crystal Growth of Lithium Niobate显示文摘 | Carruthers J R Peterson G E Grasso M | 1971 | Journal of Applied Physics1971，42，5： | 1 |
| 18 | Purification and characterization of the 22 kilodalton potato tuber proteins显示文摘 | Suh S G Peterson J E Stiekema W J | 1990 | Plant physiology1990，94，1： | 1 |
| 19 | Strengths of character and well-being显示文摘 | Park N Peterson C Seligman M E | | 0，，05： | 1 |
| 20 | Barriers to health care among people with disa- bilities who are members of underserved racial/ethnic groups : a scoping review of the literature 显示文摘 | PETERSON - BESSE J J WAKSH E S HORNER - JOHN- SON W | 2014 | Med Care2014，52，3： | 1 |
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