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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 3 | Inflammatory bowel disease course in Crohn's disease:Is the natural history changing?显示文摘Crohn’s disease(CD)is a multifactorial potentially debilitating disease.It has a variable disease course,but the majority of patients eventually develop penetrating or stricturing complications leading to repeated surgeries and disability.Studies on the natural history of CD provide invaluable data on its course and clinical predictors,and may help to identify patient subsets based on clinical phenotype.Most data are available from referral centers,however these outcomes may be different from those in population-based cohorts.New data suggest the possibility of a change in the natural history in Crohn’s disease,with an increasing percentage of patients diagnosed with inflammatory disease behavior.Hospitalization rates remain high,while surgery rates seem to have decreased in the last decade.In addition,mortality rates still exceed that of the general population.The impact of changes in treatment strategy,including increased,earlier use of immunosuppressives,biological therapy,and patient monitoring on the natural history of the disease are still conflictive.In this review article,the authors summarize the available evidence on the natural history,current trends,and predictive factors for evaluating the disease course of CD. | Petra A Golovics Michael D Mandel Barbara D Lovasz Peter L Lakatos | 2014 | World Journal of Gastroenterology2014，20，12： | 2 |
| 4 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 5 | l The clinical relevance of the fluid balance in critically illpatients显示文摘 | Petra ovicováI Sklienka P KolorL et a | 2000 | CriticalCare2000，4，1： | 1 |
| 6 | Ventilator-associated pneumonia: Increased bacterial counts in bronchoalveolar lavage by using urea as an endogenous marker of Dilution 显示文摘 | Konstantin ZL Peter S Petra A | 2005 | Crit Care Med2005，33，4： | 1 |
| 7 | Reduced growth of the cyan bacterium microcystis in an artificially mixed lake and reservoir 显示文摘 | Visser Petra M Ketelaars Henk A M | 1995 | Water Science Technology1995，32，4： | 1 |
| 8 | Theoretical analysis of a quartz-enhanced photoacoustic spectroscopy sensor显示文摘 | PETRA N ZWECK J KOSTEREV A A | 2009 | Applied Physics B2009，94，4： | 1 |
| 9 | Digital synthesizer/mixer with hybrid CORDIC-multiplier architecture:error analysis and optimization显示文摘 | De CARO D PETRA N STROLLO A G M | 2009 | IEEE Transactions on circuit and systems-I: regular papers2009，56，2： | 1 |
| 10 | Morphology and electrical resistivity of melt mixed blends of poly- ethylene and carbon nanotube filled polycarbonate 显示文摘 | J Petra Potschke Bhattacharyya A R Andreas Janke | 2003 | Polymer2003，44，： | 1 |
| 11 | Reduced growth of the cyanobacterium microcystis in an artificially mixed lake and reservioir显示文摘 | Visser Petra M Ketelaars Henk A M | 1995 | Water Science Technology1995，32，4： | 1 |
| 12 | A 630 MHz, 76 mW direct digital frequency synthesizer using enhanced ROM compression technique 显示文摘 | STROLLO A G M CARO D D PETRA N | 2007 | IEEE J Sol Sta Cire2007，42，2： | 1 |
| 13 | Angiotension II Antagonisin and the heart:Valsartan in left Ventricular hypertrophy显示文摘 | Petra A Thur Mann | 1999 | Journal of Cardiovascular Pharmacology1999，33，1： | 1 |
| 14 | Electroencephalography in the elderly显示文摘 | Davidson Petra N Davidson Keith A | 2012 | Neurodiagnostic Journal2012，52，1： | 1 |
| 15 | Salivary cortisol concentrations, stress and quality of life in women with endometriosis and chronic pelvic pain 显示文摘 | PETRELLUZZI K F GARCIA M C PETrA C A | 2008 | Stress2008，11，5： | 1 |
| 16 | Accumulation and metabolism of the anticancer flavonoid 5,7- dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish显示文摘 | Petra A Tsuji Richard N Winn Thomas Walle | 2006 | Chemico-Biological Interactions2006，164，： | 1 |
| 17 | Accumulation and metabolism of the anticancer flavonoid 5, -dimdthoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish显示文摘 | Petra A T Richard N W Thomas W | 2006 | Chem Biol Interact2006，164，4： | 1 |
| 18 | The light-dependent regulator velvet A ofAspergillus nidulans acts as a repressor of the penicillin biosynthesis显示文摘 | Petra Sprite- Axel A Brakhage | 2007 | Arch Microbio12007，，188： | 1 |
| 19 | 显示文摘 | Petra P Mahrnoud A Ingo A | 2004 | Polymer2004，45，11： | 1 |
| 20 | The growth and diffusion barrier properties of atomic layer deposited NbNx Thin Films 显示文摘 | Petra A Mikko R Kai A | 2005 | Thin Solid Films2005，491，12： | 1 |
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