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| 1 | Psychosocial issues in evidence-based guidelines on inflammatory bowel diseases: A review显示文摘AIM:To study statements and recommendations on psychosocial issues as presented in international evidence-based guidelines on the management of inflammatory bowel diseases(IBD).METHODS:MEDLINE,guidelines International Network,National Guideline Clearing House and National Institute for Health and Care Excellence were searched from January 2006 to June 30,2013 for evidencebased guidelines on the management of IBD.RESULTS:The search yielded 364 hits.Thirteen guidelines were included in the review,of which three wereprepared in Asia,eight in Europe and two in the United States.Eleven guidelines made statements and recommendations on psychosocial issues.The guidelines were concordant in that mental health disorders and stress do not contribute to the aetiology of IBD,but that they can influence its course.It was recommended that IBD-patients should be screened for psychological distress.If indicated,psychotherapy and/or psychopharmacological therapy should be recommended.IBDcentres should collaborate with mental health care specialists.Tobacco smoking patients with Crohn’s disease should be advised to quit.CONCLUSION:Patients and mental health specialists should be able to participate in future guideline groups to contribute to establishing recommendations on psychosocial issues in IBD.Future guidelines should acknowledge the presence of psychosocial problems in IBD-patients and encourage screening for psychological distress. | Winfried Huser Gabriele Moser Petra Klose Antonina Mikocka-Walus | 2014 | World Journal of Gastroenterology2014，20，13： | 14 |
| 2 | 早产儿脑发育与脑损伤的影像学评价显示文摘 | Petra S Hppi 毛健 邹丽萍 姜玉武 | 2008 | 中国循证儿科杂志2008，3，3： | 12 |
| 3 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 4 | Reelin induces EphB activation显示文摘进功能的 neuronal 网络的新生的神经原的集成在 neuronal 进程和与另外的神经原的 synaptic 接触的形成的发展中的大脑,生长和树枝状要求房间的移植到他们的最后的位置。在协调区别事件的这个复杂序列的信号之中的一个中央播放器是分泌 glycoprotein Reelin,它也调制 synaptic 粘性,学习并且在成年大脑的记忆形成。到 ApoER2 和 VLDL 受体的 Reelin 有约束力, LDL 受体家庭的二个成员,开始包含细胞内部的细胞质的适配器蛋白质 Disabled-1 的酷氨酸 phosphorylation 的发信号的串联,它指向 neuronal 细胞骨架并且最终控制在整个发展中的大脑放神经原。然而, Reelin 信号与另外的调停受体的发信号串联交往调整大脑开发和粘性的不同方面,是可能的。EphB 酷氨酸 kinases 经由通过 ephrin B transmembrane 蛋白质的双向发信号调整房间粘附和排斥依赖者过程。这里,我们证明 Reelin 绑在 EphB transmembrane 蛋白质的细胞外的领域,导致受体聚类和向前在神经原发信号的 EphB 的激活,独立于“古典”的 Reelin 受体, ApoER2 和 VLDLR。因此,鼠标缺乏 EphB1 和 EphB2 显示 CA3 海马趾的金字塔形的神经原的一个放的缺点,类似于那在 Reelin 缺乏的鼠标,和这房间迁居,缺点取决于 EphB 蛋白质的 kinase 活动。一起,我们的数据为在向前发信号的 Reelin 和 EphB 之间的信号集成提供生物化学、功能的证据。 | Elisabeth Bouche Mario I Romero-Ortega Mark Henkemeyer Timothy Catchpole Jost Leemhuis Michael Frotscher Petra May Joachim Herz Hans H Bock | 2013 | Cell Research2013，23，4： | 5 |
| 5 | Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings显示文摘 | Andreas A. Schnitzbauer Sven A. Lang Holger Goessmann Silvio Nadalin Janine Baumgart Stefan A. Farkas Stefan Fichtner-Feigl Thomas Lorf Armin Goralcyk Rüdiger H?rbelt Alexander Kroemer Martin Loss Petra Rümmele Marcus N. Scherer Winfried Padberg Alfred K? | 2012 | Annals of Surgery2012，，3： | 2 |
| 6 | Photodynamic inactivation of Escherichia coli by methylene blue incorporated in ZSM-5 zeolite channels under red LED light 显示文摘 | Miroslava S Petra O Daniela H | 2010 | Acta Chimica Slovaca2010，3，1： | 1 |
| 7 | Tensile and compressive creep behaviour of Al2O3 (Saffil) short fiber reinforeed magnesium alloy AFA2显示文摘 | HAJO D YUAN D H PETRA M | 2005 | Materials Science and Engineering A2005，41，1： | 1 |
| 8 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 9 | High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells显示文摘 | Evi B Petra Q | 1995 | Kidney international1995，47，： | 1 |
| 10 | Effects of elevated atmospheric CO2on grain quality of wheat显示文摘 | Petra Hgy Andreas Fangmeier | 2008 | Journal of Cereal Science2008，，48： | 1 |
| 11 | Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores 显示文摘 | Maria F Hubertus H Petra M etal | 2004 | Antimicrobial Agents and Chemotherapy2004，48，： | 1 |
| 12 | Clinical use of circulating nucleosomes显示文摘 | Stefan H Petra S | 2009 | Crit Rev Clin Lab Sci2009，46，1： | 1 |
| 13 | The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combina- tion with CA125 in the differential diagnosis of ovarian masses 显示文摘 | Miriam L Petra S Linda H | 2011 | Clinical chemistry and laboratory medicine2011，49，12： | 1 |
| 14 | Impact of CYP24A1 overexpression on growth of colorectal tumour xenografts in mice fed with vitamin D and soy显示文摘 | Julia H?baus Samawansha Tennakoon Petra Heffeter Charlotte Groeschel Abhishek Aggarwal Doris M. Hummel Ursula Thiem Rodrig Marculescu Walter Berger Enik? Kállay | 2016 | Int. J. Cancer2016，，2： | 1 |
| 15 | Epizootiological aspects of Streptococcus iniae affecting tilapia in Texas显示文摘 | Petra R P Johnson S K Lenis D H | 1997 | Aquac1997，152，14： | 1 |
| 16 | Spatial and temporal distribution patterns of three trophic levels in a saline lake显示文摘 | PETRA H L SCOTY D C JOHN M M | 1986 | Journal of Plankton Research1986，8，6： | 1 |
| 17 | Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (Pycnogenol)显示文摘 | Tanja Grimm Angelika Schfer Petra Hgger | 2004 | Free radical biology & medicine2004，36，6： | 1 |
| 18 | The fluorescence of ellagic acid and broax complex显示文摘 | OTTO S W PETRA H | 1986 | Monatshefte Fur Chemie1986，117，： | 1 |
| 19 | Reduction and immobilization of hexavalent chromium with coal-and humate-based sorbents显示文摘 | Pave1 Jano Václav H?la Petra Bradnová Věra Pila?ová Josef?edlbauer | | 0，，06： | 1 |
| 20 | Phenols, Proanthocyanidins, Flavones and Flavonols in Some Plant Materials and Their Antioxidant Activities显示文摘 | Mojea S Petra K Majda H | 2005 | Food Chemistry2005，89，2： | 1 |
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