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| 1 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 2 | Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs显示文摘 | Geert Robaeys Jason Grebely Stefan Mauss Philip Bruggmann Joseph Moussalli Andrea De Gottardi Tracy Swan Amber Arain Achim Kautz Heino St?ver Heiner Wedemeyer Martin Schaefer Lynn Taylor Markus Backmund Olav Dalgard Maria Prins Gregory J. Dore | 2013 | Clinical Infectious Diseases . 2013 (supp)2013，，： | 1 |
| 3 | Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs显示文摘 | Geert Robaeys Jason Grebely Stefan Mauss Philip Bruggmann Joseph Moussalli Andrea De Gottardi Tracy Swan Amber Arain Achim Kautz Heino St?ver Heiner Wedemeyer Martin Schaefer Lynn Taylor Markus Backmund Olav Dalgard Maria Prins Gregory J. Dore | 2013 | Clinical Infectious Diseases (suppl )2013，，2： | 1 |
| 4 | Homocysteine Impairs the Nitric Oxide Synthase Pathway: Role of Asymmetric Dimethylarginine显示文摘 | Markus C. Stühlinger Philip S. Tsao Jeng-Horng Her Masumi Kimoto Robert F. Balint John P. Cooke | 2001 | Circulation: Journal of the American Heart Association2001，，： | 1 |
| 5 | Effect of rotation on the radiographic appearance of the femoral canal显示文摘 | Stephen G JE Philip CN Hugh ST | 1994 | J Arthroplasty1994，9，4： | 1 |
| 6 | Plasma Asymmetric Dimethylarginine Concentrations Are Elevated in Obese Insulin-Resistant Women and Fall with Weight Loss显示文摘 | Tracey McLaughlin Markus Stühlinger Cindy Lamendola Fahim Abbasi Joan Bialek Gerald M. Reaven Philip S. Tsao | 2006 | The Journal of Clinical Endocrinology & Metabolism2006，，5： | 1 |
| 7 | 查看详情显示文摘 | Philip St J Russell | | 0，，： | 1 |
| 8 | Structure of the O‐Glycosylated Conopeptide CcTx from Conus consors Venom显示文摘 | Henry G. Hocking Gerrit J. Gerwig Sébastien Dutertre Aude Violette Philipe Favreau Reto St?cklin Johannis P. Kamerling Rolf Boelens | 2012 | Chem Eur J2012，，3： | 1 |
| 9 | Use of a cryptic splicesite for the expression of huntingtin interacting protein 1 inselect normal and neoplastic tissues显示文摘 | Graves CW Philips ST Bradley SV etal | 2008 | Cancer Res2008，68，4： | 1 |
| 10 | Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson’s disease: a dose escalation, open-label, phase 1/2 trial显示文摘 | Stéphane Palfi Jean Marc Gurruchaga G Scott Ralph Helene Lepetit Sonia Lavisse Philip C Buttery Colin Watts James Miskin Michelle Kelleher Sarah Deeley Hirokazu Iwamuro Jean Pascal Lefaucheur Claire Thiriez Gilles Fenelon Cherry Lucas Pierre Brugières Ina | 2014 | The Lancet2014，，： | 1 |
| 11 | Description and Evaluation of an Acute Stroke Unit显示文摘 | PHILIPS ST ESKES G GUBITZ GJ | 2002 | CMAJ(S0008-4409)2002，167，： | 1 |
| 12 | Determination of polybrominated diphenyl ethers in marine biological tissues using microwave-assisted extraction显示文摘 | Stéphane Bayen Hian Kee Lee Jeffrey Philip Obbard | 2004 | Journal of Chromatography A2004，，： | 1 |
| 13 | Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs显示文摘 | Geert Robaeys Jason Grebely Stefan Mauss Philip Bruggmann Joseph Moussalli Andrea De Gottardi Tracy Swan Amber Arain Achim Kautz Heino St?ver Heiner Wedemeyer Martin Schaefer Lynn Taylor Markus Backmund Olav Dalgard Maria Prins Gregory J. Dore | 2013 | Clinical Infectious Diseases (suppl )2013，，2： | 1 |
| 14 | Beh?et’s disease: Ocular effects and treatment显示文摘 | Christoph M.E. Deuter Ina K?tter Graham R. Wallace Philip I. Murray Nicole Stübiger Manfred Zierhut | 2007 | Progress in Retinal and Eye Research2007，，1： | 1 |
| 15 | Variable location of accessory pathways associated with the permanent form of junctional reciprocating tachycardia and confirmation with radiofrequency ablation显示文摘 | Baruch ST Philip S Edward H | 1992 | Am J Cardiol1992，70，： | 1 |
| 16 | Chlorinated paraffins: A review of analysis and environmental occurrence显示文摘 | Stéphane Bayen Jeffrey Philip Obbard Gareth O. Thomas | 2006 | Environment International2006，，7： | 1 |
| 17 | Occurrence and detection of AmpC beta - lactamases among Escherichia Coli , Klebsiella Pneumoniae and Proteus mirabilis Isolates at a Veterans Medical Center显示文摘 | Philip Ee Ellen SM Kenneth ST | 2000 | J Clinical Microbiology2000，38，5： | 1 |
| 18 | IPM Strategies and Their Dilemmas Including an Introduction to www. eurowheat.org显示文摘Information about disease management in winter wheat(Triticum aestiva)in eight European countries was collated and analysed by scientists and extension workers within the European Network for the Durable Exploitation of Crop Protection Strategies(ENDURE).This included information about specif ic disease thresholds,decision support systems,host varieties,disease prevalence and pathogen virulence.Major differences in disease prevalence and economic importance were observed.Septoria tritici blotch(Mycosphaerella graminicola)was recognized as the most yield reducing disease in countries with intensive wheat production,but also rust diseases(Puccinia striiformis and Puccinia triticina),powdery mildew(Blumeria graminis)and Fusarium head blight(Fusarium spp.)were seen as serious disease problems.Examples of current integrated pest management(IPM)strategies in different countries have been reported.Disease management and fungicide use patterns showed major differences,with an average input equivalent to 2.3 full dose rates(TFI)in the UK and a TFI of 0.6 in Denmark.These differences are most likely due to a combination of different cropping systems,climatic differences,disease prevalence,and socio-economic factors.The web based information platform www.eurowheat.org was used for dissemination of information and results including information on control thresholds,cultural practices which can infl uence disease attack,fungicide eff icacy,fungicide resistance,and pathogen virulence,which are all elements supporting IPM for disease control in wheat.The platform is open to all users.The target groups of EuroWheat information are researchers,advisors,breeders,and similar partners dealing with disease management in wheat. | Lise Nistrup Jφrgensen Mogens Stφvring Hovmφller Jens Grφnbk Hansen Poul Lassen Bill Clark Rosemary Bayles Bernd Rodemann Kerstin Flath Margot Jahn Tomas Goral Jerzy Czembor J Philip Cheyron Claude Maumene Claude De Pope Rita Ban Ghita Cordsen Nielsen Gunilla Berg | 2014 | Journal of Integrative Agriculture2014，13，2： | 1 |
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