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| 1 | Deformation characteristics and genesis of the Waziyu metamorphic core complex in western Liaoning of China显示文摘The Waziyu metamorphic core complex is situated at the eastern end of the Yanshan tectonic belt.The NNE-striking detachment ductile shear zone in the core complex lies between the Archean metamorphic basement and Fuxin-Yixian rift basin,dips NW gently,and shows corrugation folds.Exposure structures,microstructures,and quartz C-axis fabrics all indicate top-to-the WNW sense of shear,i.e.,ca.285°,for the shear zone.Estimates of the deformation temperatures(ca.550-250°C) demonstrate its mid-crustal origination and progressive deformation from deep to shallow levels.The northern segment of the shear zone shows relatively weak exhumation with exposures of low-temperature mylonites whereas its middle and southern segments have more intense uplifting with exposures of high-temperature mylonites.Biotite and muscovite 40 Ar/39 Ar ages,U-Pb dating results of zircon from dikes and plutons as well as formation ages of the supra-detachment basin all suggest the formation time of 135-100 Ma for the core complex.The formation was also associated with syntectonic emplacement of the Early Cretaceous Shishan pluton.The western margin of the core complex was truncated by the Sunjiawan-Shaohuyingzi brittle normal fault when it uplifted to shallow crust levels,and finally exhumed to near-surface levels.The core complex was developed by the rolling-hinge model under WNW-ESE extension during the Early Cretaceous peak destruction of the North China Craton.Ductile flow did not appear in the lower plate,therefore not supporting the low-crust gravitational collapse. | ZHANG BiLong ZHU Guang CHEN Yin PIAO XueFeng JU LinXue WANG HaoQian | 2012 | Science China Earth Sciences2012，55，11： | 4 |
| 2 | Construction of Artificial Intelligence Practical Courses based on ModelArts显示文摘With more and more colleges and universities set up artificial intelligence undergraduate major,the cultivation of artificial intelligence undergraduate has become a hot topic.The cultivation of AI undergraduates should draw on the successful experience of software engineering major,pay attention to cooperation with enterprises,and introduce case and project teaching.The paper presents one curriculum system of AI undergraduates major and practice courses based on Huawei’s ModelArts platform. | Jianrui Ding Guodong Xin Xuefeng Piao Dongjie Zhu | 2020 | 计算机教育2020，，12： | 1 |
| 3 | MINE:A Method of Multi-Interaction Heterogeneous Information Network Embedding显示文摘Interactivity is the most significant feature of network data,especially in social networks.Existing network embedding methods have achieved remarkable results in learning network structure and node attributes,but do not pay attention to the multi-interaction between nodes,which limits the extraction and mining of potential deep interactions between nodes.To tackle the problem,we propose a method called Multi-Interaction heterogeneous information Network Embedding(MINE).Firstly,we introduced the multi-interactions heterogeneous information network and extracted complex heterogeneous relation sequences by the multi-interaction extraction algorithm.Secondly,we use a well-designed multi-relationship network fusion model based on the attention mechanism to fuse multiple interactional relationships.Finally,applying a multitasking model makes the learned vector contain richer semantic relationships.A large number of practical experiments prove that our proposed method outperforms existing methods on multiple data sets. | Dongjie Zhu Yundong Sun Xiaofang Li Haiwen Du Rongning Qu Pingping Yu Xuefeng Piao Russell Higgs Ning Cao | 2020 | Computers, Materials & Continua2020，，6： | 0 |
| 4 | Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate显示文摘Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals,controlling metabolic states beyond energy metabolism.However,whether glycolytic metabolites also play a role in controlling cell fate remains unexplored.Here,we find that low levels of glycolytic metabolite 3-phosphoglycerate(3-PGA)can switch phosphoglycerate dehydrogenase(PHGDH)from cataplerosis serine synthesis to pro-apoptotic activation of p53.PHGDH is a p53-binding protein,and when unoccupied by 3-PGA interacts with the scaffold protein AXIN in complex with the kinase HIPK2,both of which are also p53-binding proteins.This leads to the formation of a multivalent p53-binding complex that allows HIPK2 to specifically phosphorylate p53-Ser46 and thereby promote apoptosis.Furthermore,we show that PHGDH mutants(R135W and V261M)that are constitutively bound to 3-PGA abolish p53 activation even under low glucose conditions,while the mutants(T57A and T78A)unable to bind 3-PGA cause constitutive p53 activation and apoptosis in hepatocellular carcinoma(HCC)cells,even in the presence of high glucose.In vivo,PHGDH-T57A induces apoptosis and inhibits the growth of diethylnitrosamine-induced mouse HCC,whereas PHGDH-R135W prevents apoptosis and promotes HCC growth,and knockout of Trp53 abolishes these effects above.Importantly,caloric restriction that lowers whole-body glucose levels can impede HCC growth dependent on PHGDH.Together,these results unveil a mechanism by which glucose availability autonomously controls p53 activity,providing a new paradigm of cell fate control by metabolic substrate availability. | Yu-Qing Wu Chen-Song Zhang Jinye Xiong Dong-Qi Cai Chen-Zhe Wang Yu Wang Yan-Hui Liu Yu Wang Yiming Li Jian Wu Jianfeng Wu Bin Lan Xuefeng Wang Siwei Chen Xianglei Cao Xiaoyan Wei Hui-Hui Hu Huiling Guo Yaxin Yu Abdul Ghafoor Changchuan Xie Yaying Wu Zheni Xu Cixiong Zhang Mingxia Zhu Xi Huang Xiufeng Sun Shu-Yong Lin Hai-Long Piao Jianyin Zhou Sheng-Cai Lin | 2023 | Cell Research2023，33，11： | 0 |
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