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| 1 | Relationship of MTHFR gene polymorphisms with renal and cardiac disease显示文摘AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are controversial.METHODS: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism. | Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri Maria Antonietta Buccheri Concetta Di Nora Guglielmo M Trovato | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | The fluid mechanics of pulsed laser propulsion显示文摘 | Simons G A Pirri N A | 1977 | AIAA Journal1977，15，6： | 1 |
| 3 | Antimicrobial peptides: an overview of a promising class of therapeutics显示文摘 | Giuliani A Pirri G Nicoletto S | 2007 | Cent Eur J Biol2007，2，1： | 1 |
| 4 | Lifestyle interventions,insulin resistance,and renal artery stiffness in essential hypertension显示文摘 | TROVATO G M PIRRI C MARTINES G F | 2010 | Clin Exp Hypertens2010，32，： | 1 |
| 5 | Plasma energy transfer to metal surfaces irradiated by pulsed lasers显示文摘 | Pirri A N Root R G P Wu K S | 1978 | AIAA J1978，16，12： | 1 |
| 6 | Synthesis of novel 60ullerene-flavonoid dyads显示文摘 | Maria D L Marcorin G L Pirri G | 2002 | Tetrahedron Letters2002，43，9： | 1 |
| 7 | Lipopeptides as anti-in- fectives : a practical perspective 显示文摘 | Pirri G Giuliani S Nicoletto S | 2009 | Central European Journal of Biology2009，4，3： | 1 |
| 8 | Antimicrobial peptides: an overview of a promising class of therapeutics显示文摘 | Giuliani A Pirri G Nicoletto S F | 2007 | Cent Eur J Biol2007，2，1： | 1 |
| 9 | 显示文摘 | Reitano R Foti G Pirri C F | 2001 | Materials Science and Engineering:C2001，15，12： | 1 |
| 10 | Optimization of α-Si1-xCx:H films prepared by ultrahigh vacuum plasma enhanced chemical vapour deposition for electroluminescent devices显示文摘 | Demichelis F Crovini G Pirri C F | 1994 | Thin Solid Films1994，241，： | 1 |
| 11 | ADV36 adipogenic adenovirus in human liver disease显示文摘obesity and liver steatosis are usually described as related diseases.obesity is regarded as exclusive consequence of an imbalance between food intake and physical exercise,modulated by endocrine and genetic factors.Non-alcoholic fatty liver disease(NAFLD),is a condition whose natural history is related to,but not completely explained by over-nutrition,obesity and insulin resistance.There is evidence that environmental infections,and notably adipogenic adenoviruses(ADV)infections in humans,are associated not only with obesity,which is sufficiently established,but also with allied conditions,such as fatty liver.In order to elucidate the role,if any,of previous ADV36 infection in humans,we investigated association of ADV36-ADV37 seropositivity with obesity and fatty liver in humans.Moreover,the possibility that lifestyle-nutritional intervention in patients with NAFLD and different ADV36 seropositive status,achieves different clinical outcomes on ultrasound bright liver imaging,insulin resistance and obesity was challenged.ADV36 seropositive patientshave a more consistent decrease in insulin resistance,fatty liver severity and body weight in comparison with ADV36 seronegative patients,indicating a greater responsiveness to nutritional intervention.These effects were not dependent on a greater pre-interventional body weight and older age.These results imply that no obvious disadvantage-and,seemingly,that some benefit-is linked to ADV36 seropositivity,at least in NAFLD.ADV36 previous infection can boost weight loss and recovery of insulin sensitivity under interventional treatment. | Francesca M Trovato Daniela Catalano Adriana Garozzo G Fabio Martines Clara Pirri Guglielmo M Trovato | 2014 | World Journal of Gastroenterology2014，20，40： | 1 |
| 12 | Mineralogical and geochemical signature of mine waste contamination, Trsillian River, Fal Estuary, Cornwall, UK显示文摘 | Pirrie D Camm G S Sear L G | 1997 | Environmental Geology1997，29，12： | 1 |
| 13 | Intraopera- tire image-guided spinal navigation: technical pitfalls and their avoldance显示文摘 | Rahmathulla G Nottmeier EW Pirris SM | 2014 | Neurosurg Focus2014，36，3： | 1 |
| 14 | Mineralogical and geochemical signature of mine waste contamination, Trsillian River, FalEstrary, Cormwall, UK显示文摘 | Pirrie D Camm G S sear LG | 1997 | Environmental Geology1997，29，12： | 1 |
| 15 | Room temperature blue light emission from ECR-CVD deposited nano-crystalline SiC 显示文摘 | FOTI G PIRRI C F | 2001 | Materials Science and Engineering C2001，15，： | 1 |
| 16 | Antimicrobial peptides : an over- view of a promising class of therapeutics 显示文摘 | Giuliani A Pirri G Nicoletto SF | 2007 | Cent Eur J Biol2007，2，1： | 1 |
| 17 | Lipopeptides as anti-infectives:A practical perspective显示文摘 | PIRRI G GIULIANI A NICOLETTO S F | 2009 | Central European Journal of Biology2009，4，3： | 1 |
| 18 | Laser ignition of plasma off aluminum surfaces 显示文摘 | Weyl G Pirri A Root R | 1980 | AIAA Journal1980，19，4： | 1 |
| 19 | Optimization of a - Si1-xCx : H films prepared by ultrahigh vacuum plasma enhanced chemical Vapor deposition for electroluminescent devices 显示文摘 | Demichelis :F Crovini G Pirri C F | 1994 | Thin solid Films1994，241，12： | 1 |
| 20 | The fluid mechanics of pulsed laser propulsion显示文摘 | SIMONS G A PIRRI N | 1977 | AIAA Journal1977，15，6： | 1 |
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