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| 1 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 2 | Fertilizing capacity of frozen boar semen following surgical insemination显示文摘 | Polge C Salamon S Wilmut I | 1970 | Vet Rec1970，87，15： | 1 |
| 3 | Revival of spermatozoa after vitrification and dehydration at low temperatures 显示文摘 | POLGE C SMITH A U PAPKES A S | 1949 | Nature1949，164，4172： | 1 |
| 4 | Revival of spermatozoa 'after vitrification and dehydration at low temprature 显示文摘 | Polge C Smith A U Parkes A S | 1949 | Nature1949，164，： | 1 |
| 5 | Fertility capability of frozen boar semen following surgical insemination显示文摘 | Polge C Salamon S Wlmut I | 1970 | Vet Rec1970，87，15： | 1 |
| 6 | Revival of spermatozoa after vitrification and dehydration at low temperature 显示文摘 | Polge C Smith A U Parkes A S | 1949 | Nature1949，164，： | 1 |
| 7 | Fertilizing capacity of frozen boar semen following surgical insemlnation显示文摘 | Polge C Salamon S Wilmut I | 1970 | Vet Rec1970，87，15： | 1 |
| 8 | Revival of spermatozoa after vitrification and dehydration at low temperatures 显示文摘 | Polge C Smith A V Parkes A S | 1949 | Nature1949，164，： | 1 |
| 9 | Deep freez- ing of sheep embryos显示文摘 | Willadsen S M Polge C Rowson L E | 1976 | J Reprod Ferti11976，46，1： | 1 |
| 10 | Revival of spermatozoa after vitrification and dehydration at low temperature显示文摘 | Polge C Smith AV Parkes A S | 1949 | Nature1949，164，： | 1 |
| 11 | Fertilizing capacity of frozen boar semen following surgical insemination显示文摘 | Polge C Salamon S Wilmut I | 1970 | VetRec1970，87，15： | 1 |
| 12 | Comparison of the diagnostic value of cardiac troponin I and T determinations for detecting early myocardial damage and the relationship with histological findings after isoprenaline-induced cardiac injury in rats显示文摘 | Bertinchant JP Robert E Polge A Marty-Double C Fabbro-Peray P Poirey S | 2000 | Clin Chim Acta2000，298，12： | 1 |
| 13 | Revival of spermatozoa after vitrification and dehydration at low temperature 显示文摘 | Polge C Smith A U Parkes A S | 1949 | Nature1949，164，4172： | 1 |
| 14 | Efficient computation of packet CRC from partial CRCs with application to the Cells- In-Frames protocol 显示文摘 | ROGINSKY A L CHRISTENSEN K POLGE S | 1998 | Computer Communications1998，21，6： | 1 |
| 15 | Vesicle-associated mem-brahe protein 3(VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion显示文摘 | POLGáR CHUNG S H REED G L | | 0，，03： | 1 |
| 16 | Fertilizing capacity of frozen boar semen following surgical insemination显示文摘 | Polge C Salamon S Wilmut I | | 0，，： | 1 |
| 17 | Revival of spermatozoa after vitrification and dehydration at low temperature显示文摘 | POLGE C SMITH A U PARKES A S | 1949 | Nature1949，164，： | 1 |
| 18 | Revival of spermatozoaafter vitrification and dehydration at low temperatures显示文摘 | Polge C Smith A U Parkes A S | 1949 | Nature1949，666，： | 1 |
| 19 | Revival of spermatozoa after vitrification and dehydration at low temperature 显示文摘 | Polge C Smith A U 'Parkes A S | 1949 | Nature1949，164，： | 1 |
| 20 | Attempts to produce monozygotic quadruplets in cattle by blastomere separation显示文摘 | Willadsen S M Polge C | 1981 | Vet Rec1981，108，： | 1 |
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