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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Epidermal growth factor receptor inhibits colitis-associated cancer in mice显示文摘 | Dubé Philip E Yan Fang Punit Shivesh Girish Nandini McElroy Steven J Washington M Kay Polk D Brent | 2012 | EN2012，，8： | 2 |
| 3 | Deep space 1 measurements of ion propulsion contamination显示文摘 | Brinza D Wang J Polk J | 2001 | Journal of Spacecraft and Rockets2001，38，3： | 1 |
| 4 | Financial Constraints and Stock Returns显示文摘 | Lamont O Polk C Saa-Requejo J | 2001 | Review of Financial Studies2001，14，2： | 1 |
| 5 | ISE analysis of hydrogen sulfide in cigarette smoke显示文摘 | Li G Polk B J Meazell L A | 2000 | Journal of Chemical Education2000，77，08： | 1 |
| 6 | Vaccines in aquaculture: The search for an effecient delivery system 显示文摘 | Dunn E J Polk A Scarrett D J | 1990 | Aquacuh Eng1990，9，： | 1 |
| 7 | Refractory amorphous inter-transition metal alloys显示文摘 | GIESSEN B C MAHAVA M POLK D E VANDER SANDE J | 1976 | Materials Science and Engineering1976，23，： | 1 |
| 8 | Synthesis and characterization of bis-azido methyl oxetane and its polymer and copolymer with tetrahydrofuran显示文摘 | Nair J K Satpute R S Polke B G | 2002 | Defence Science J2002，52，2： | 1 |
| 9 | Financial Constraints and Stock Returns 显示文摘 | Lamont O Polk C Saa-Requejo J | 2001 | Review of Financial Studies2001，14，2： | 1 |
| 10 | Three-Dimensional Par-ticle Simulations of Ion-Optics Plasma Flow and Grid Ero-sion显示文摘 | Wang J Polk J Brophy J | 2003 | Journal of Propulsion and Power2003，19，6： | 1 |
| 11 | Financial Constraints and Stock Returns 显示文摘 | Lamont O Polk C Saa- Requejo J | 2001 | The Review of Financial Studies Summer2001，，14： | 1 |
| 12 | Clinical and economic outcomes of oral linezolid versus intravenous vancomycin in the treatment of MRSA-complicated, lower-extremity skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus显示文摘 | Sharpe J N Shively E H Polk Jr H C | 2005 | Am J Surg2005，189，4： | 1 |
| 13 | A new algorithm for calculating HVDC corona with the presence of wind显示文摘 | YU M KUFFEL E POLK J | 1992 | IEEE Tranemations on Magnetics1992，28，5： | 1 |
| 14 | Prehospital tracheal intubating conditions during rapid sequence intubation: rocuronium versus vecuronium显示文摘 | SMITH C E KOVACH B POLK J D etal | 2002 | Air Med J2002，21，： | 1 |
| 15 | 3D Particle Simulations of Ion Optics Plasma Flow and Grid Erosion显示文摘 | WANG J POLK J E BROPHY J | 2003 | Journal of Pro- pulsion and Power2003，19，6： | 1 |
| 16 | Financial Constraints and Stock Returns显示文摘 | Lamont O Polk C Saa -Requejo J | 2001 | Review of Financial Studies2001，14，2： | 1 |
| 17 | Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort显示文摘 | Davidson G Murphy S Polke J | 2012 | J Neurol2012，259，8： | 1 |
| 18 | Neuropharmacology of St John's Wort (Hypericum)显示文摘 | Bennett DA Jr Phun polk J F | 1998 | Ann Pharmacother1998，32，11： | 1 |
| 19 | Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction显示文摘 | Port JD Walker LA Polk J | 2011 | Physiol Genomics2011，43，19： | 1 |
| 20 | Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells显示文摘 | Weishaupt J H Rohde G Polking E | 2004 | Invest Ophthalmol Vis Sci2004，45，5： | 1 |
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