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| 1 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 2 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 3 | Carbon-supported sulfide catalysts显示文摘 | DUCHET J C Van OERS E M De BEER V H J PRINS R | 1983 | J Catal1983，80，2： | 1 |
| 4 | Use of imatinib in a patient with cutaneous vasculopathy in the context of von Recklinghausen disease/ neurofibromatosis 显示文摘 | KHELIFA I SAURAT J H PRINS C | 2015 | Br J Derrnatol2015，172，1： | 1 |
| 5 | Bicarbonate utilization:function and mechanism显示文摘 | Prins H B A Elzenga J T M | 1989 | Aquatic Botany1989，34，1： | 1 |
| 6 | Structure and function of the catalyst and the promoter in Co-Mo hydrodesul- furization catalysts 显示文摘 | PRINS R DE BEER V H J SOMORJAI G A | 1989 | Catalysis Reviews--Science and Engi- neering1989，31，12： | 1 |
| 7 | Effects of the enterokinetic prucalopride (R093877) on colonic motility in fasted dogs显示文摘 | Briejer M R Prins N H Schuurkes J A | 2001 | Neurogastroenterol Motil2001，13，： | 1 |
| 8 | Diabetic cardiomyopathy:evidence,mechanisms,and therapeutic implications显示文摘 | Fang Z Y Prins J B Marwick T H | 2004 | Endocr Rev2004，25，4： | 1 |
| 9 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 10 | Bicarbonate utilization:function and mechanism显示文摘 | Prins H B A Elzenga J T M | 1989 | Aquatic Botany1989，34，： | 1 |
| 11 | Hydrodenitrogenation of quinoline over carbon-supported transition-metal sulfides显示文摘 | Sonja E De Beer V H J Prins R | 1991 | Journal of Catalysis1991，127，2： | 1 |
| 12 | Structure of molybdenum sulfide in carbon supported Mo and CoMo sulfide catalysts as studied by extended X-ray absorption fine structure spectroscopy显示文摘 | Bouwens S M A M Prins R de Beer V H J | 1990 | J Phys Chern1990，94，： | 1 |
| 13 | Inhibition of monoamine oxidase by indole and benzofuran derivatives显示文摘 | Prins L H Petzer J P Malan S F | 2010 | Eur J Med Chem2010，45，10： | 1 |
| 14 | In vitro induction of alkaline phosphatase levels predicts in vivo bone forming capacity of human bone marrow stromal cells显示文摘 | PRINS H J BRAAT A K GAWLITTA D | 2013 | Stem Cell Res2013，12，： | 1 |
| 15 | Structure and function of the catalyst and the promoter in Co-Mo hydrodesulfurization catalysts显示文摘 | PRINS R DE BEER V H J SOMORJAI G A | 1989 | Catal RevSci Eng1989，31，12： | 1 |
| 16 | Optimised padlock probe ligation and microarray detection of multiple (non-authorised) GMOs in a single reaction显示文摘 | Prins T W van Dijk J P Beenen H G | 2008 | BMC Genomics2008，9，： | 1 |
| 17 | Reversible electrowetting and trapping of charge:Model and experiments显示文摘 | Verheijen H J J Prins M W J | 1999 | Langmuir1999，15，20： | 1 |
| 18 | A physical map of the Thinopyrum-derived Lr19 translocation 显示文摘 | Prins R Marais G F Janse B J H etal | 1996 | Genome1996，39，： | 1 |
| 19 | Diabetic cardiomyopathy:evidence,mechanisms,and therapeutic implications显示文摘 | Fang Z Y Prins J B Marwick T H | 2004 | Endocrine Rviews2004，25，： | 1 |
| 20 | Bicarbonate utilization:Function and mechanism显示文摘 | Prins H B A Elzenga J T M | 1989 | Aquatic Botany1989，34，13： | 1 |
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