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| 1 | Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure显示文摘AIM: To assess the management and outcome of nonerosive gastro-esophageal reflux disease (NERD) patients who were identified retrospectively, after a 5-year follow-up.METHODS: We included patients with gastro-esophageal reflux disease (GERD) symptoms who had a negative endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years (range 3.5-7 years) by means of a structured questionnaire to assess presence of GERD symptoms, related therapy, updated en-doscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical analysis.RESULTS: 260 patients (137 women) were included. Predominant GERD symptoms were heartburn andregurgitation in 103/260 (40%). 70% received a maintenance treatment, which was proton pump inhibitor (PPI) in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of follow-up were observed. A progression to erosive gastro-esophageal reflux disease (ERD) was found in 58/193 (30.0%) of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION: This study shows that progression to ERD occurs in about 5% of NERD cases per year, despite therapy. Only two factors consistently and independently influence progression: smoking and absence of PPI therapy. | Fabio Pace Stefano Pallotta Gianpiero Manes Annalisa de Leone Patrizia Zentilin Luigi Russo Vincenzo Savarino Matteo Neri Enzo Grossi Rosario Cuomo | 2009 | World Journal of Gastroenterology2009，15，45： | 8 |
| 2 | Gastroesophageal reflux disease management according to contemporary international guidelines:A translational study显示文摘AIM:To test the Genval recommendations and the usefulness of a short trial of proton pump inhibitor(PPI) in the initial management and maintenance treatment of gastroesophageal reflux disease(GERD)patients. METHODS:Five hundred and seventy seven patients with heartburn were recruited.After completing a psychometric tool to assess quality of life(PGWBI)and a previously validated GERD symptom questionnaire (QUID),patients were grouped into those with esophagitis(EE,n=306)or without mucosal damage (NERD,n=271)according to endoscopy results. The study started with a 2-wk period of high dose omeprazole(omeprazole test);patients responding to this PPI test entered an acute phase(3 mo)of treatment with any PPI at the standard dose.Finally,those patients with a favorable response to the standard PPI dose were maintained on a half PPI dose for a further 3-mo period. RESULTS:The test was positive in 519(89.9%)patients,with a greater response in EE patients(96.4%) compared with NERD patients(82.6%)(P=0.011). Both the percentage of completely asymptomatic patients,at 3 and 6 mo,and the reduction in heartburn intensity were significantly higher in the EE compared with NERD patients(P<0.01).Finally,the mean PGWBI score was significantly decreased before and increased after therapy in both subgroups when compared with the mean value in a reference Italian population. CONCLUSION:Our study confirms the validity of the Genval guidelines in the management of GERD patients. In addition,we observed that the overall response to PPI therapy is lower in NERD compared to EE patients. | Fabio Pace Gabriele Riegler Annalisa de Leone Patrizia Dominici Enzo Grossi the EMERGE Study Group | 2011 | World Journal of Gastroenterology2011，17，9： | 5 |
| 3 | Colorectal cancer and 18FDG-PET/CT:What about adding the T to the N parameter in loco-regional staging?显示文摘AIM:To evaluate whether FDG-positron emission tomography(PET)/computed tomography(CT)may be an accurate technique in the assessment of the T stage in patients with colorectal cancer.METHODS:Thirty four consecutive patients(20 men and 14 women;mean age:63 years)with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study.All patients underwent FDG-PET/CT preoperatively.The primary tumor site and extent were evaluated on PET/CT images.Colorectal wall invasion was analysed according to a modified T classification that considers only three stages(≤T2,T3,T4).Assessment of accuracy was carried out using 95%confidence intervals for T.RESULTS:Thirty five/37(94.6%)adenocarcinomas were identified and correctly located on PET/CT images.PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3%(95%CI:87%-100%).All T1,T3 and T4 lesions were correctly staged,while two T2 neoplasms were overstated as T3.CONCLUSION:Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer. | Pier Paolo Mainenti Delfina Iodice Sabrina Segreto Giovanni Storto Mario Magliulo Giovanni Domenico De Palma Marco Salvatore Leonardo Pace | 2011 | World Journal of Gastroenterology2011，17，11： | 5 |
| 4 | Cutaneous myiasis of the breast: mammographic and us features-report of five cases显示文摘 | de Barros N D'Avila MS de Pace Bauab S | 2001 | Radiology2001，218，2： | 1 |
| 5 | Patients treated with antitumor drugs displaying neurological deficits are char- acterized by a low circulating level of nerve growth factor 显示文摘 | de Santis S Pace A Bove L | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 6 | Characterization of IcmF of the type VI secretion system in an avian pathogenic Escherichia coli ( APEC ) strain 显示文摘 | de Pace F Boldrin de Paiva J Nakazato G | 2011 | Microbiology2011，157，10： | 1 |
| 7 | Pancreas and Liver Injury Are Associated in Individuals With Increased Alcohol Consumption显示文摘 | Andrea Pace Andreas de Weerth Marc Berna Katharina Hillbricht Michael Tsokos Michael Bl?ker Klaus Pueschel Ansgar W. Lohse | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 1 |
| 8 | Inflammation and endothelial activation in benign prostatic hyperplasia and prostate cancer显示文摘 | PACE G di MASSIMO C de AMICIS D | 2011 | Int Braz J Urol2011，37，5： | 1 |
| 9 | Is flexible bronchoscopy necessary to confirm the position of double-lumen tubes before thoracic surgery? ☆显示文摘 | Mario de Bellis Rosanna Accardo Massimo Di Maio Carmine Lamanna Giovanni Battista Rossi Maria Caterina Pace Vincenzo Romano Gaetano Rocco | 2011 | European Journal of Cardio-Thoracic Surgery2011，，4： | 1 |
| 10 | Chromosomal location of isozymes and seed storage protein gene in Dasypyrum villosum (L) Candargy 显示文摘 | Montebove L De Pace C Jan C C | 1987 | Theoretical and Application Genetics1987，73，： | 1 |
| 11 | Minimally invasive adrenalectomy for pheochromocytoma during pregnancy显示文摘 | Pace DE Chiasson PM Schlachta CM | 2002 | Surg laparosc Endosc Percutan Tech2002，12，2： | 1 |
| 12 | Laparoscopic splenectomy for idiopathic thrombocytopenic purpura (ITP)显示文摘 | Pace DE Chiasson PM Schlachta CM | 2003 | Surg Endosc2003，17，1： | 1 |
| 13 | Molecular and chromosomal characterization of repeated and single-copy DNA sequences in the genome of Dasypyrum villosum显示文摘 | DE PACE C DELRE V SCARASCIA MUGNOZZA G T QUALSET C O CREMONINI R FREDIANI M CIONINI P G | 1992 | Hereditas1992，116，： | 1 |
| 14 | Patients treated with antitumor drugs displaying neurological deficits are characterized by a low circulating level of nerve growth factor 显示文摘 | De Santis S Pace A Bove L | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 15 | Genetics, diagnosis and management of colorectal cancer (Review)显示文摘 | Marina De Rosa Ugo Pace Daniela Rega Valeria Costabile Francesca Duraturo Paola Izzo Paolo Delrio | 2015 | Oncology Reports2015，，： | 1 |
| 16 | Environmental diversity of Bacteria and Archaea显示文摘 | De LONG E E PACE N R | 2001 | Systematic Biology2001，50，4： | 1 |
| 17 | Characterization of IcmF of the type VI secretion system in an avian pathogenic Escherichia coli (APEC) strain 显示文摘 | de Pace F Boldrin de Paiva J Nakazato G | 2011 | Microbiology2011，157，11： | 1 |
| 18 | Introgression of Dasypyrum villosum chromatin into common wheat improves grain protein quality显示文摘 | De Pace C Snidaro D Ciaffi M | 2001 | Euphytica2001，117，： | 1 |
| 19 | Patients treated with antitumor drugs displaying neurologicaldeficits are characterized by a low circulating level of nerve growth factor 显示文摘 | De Santis S Pace A Bove L | 2000 | Clinical cancerresearch2000，6，1： | 1 |
| 20 | Expression of tumor necrosis factor-alpha in mouse spermatogenic cells 显示文摘 | Chen HL Pace JL | 1993 | Endocrinology1993，133，： | 1 |
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