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| 1 | Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit;a critical review显示文摘The emergence of antibiotic resistant bacteria in the healthcare is a serious concern.In the Healthcare premises precisely intensive care unit are major sources of microbial diversity.Recent findings have demonstrated not only microbial diversity but also drug resistant microbes largely habitat in ICU.Pseudomonas aeruginosa found as a part of normal intestinal flora and a significant pathogen responsible for wide range of ICU acquired infection in critically ill patients.Nosocomial infection associated with this organism including gastrointestinal infection,urinary tract infections and blood stream infection.Infection caused by this organism are difficult to treat because of the presence of its innate resistance to many antibiotics(b-lactam and penem group of antibiotics),and its ability to acquire further resistance mechanism to multiple class of antibiotics,including Beta-lactams,aminoglycosides and fluoroquinolones.In the molecular evolution microbes adopted several mechanism to maintain genomic plasticity.The tool microbe use for its survival is mainly biofilm formation,quorum sensing,and horizontal gene transfer and enzyme promiscuity.Such genomic plasticity provide an ideal habitat to grow and survive in hearse environment mainly antibiotics pressure.This review focus on infection caused by Pseudomonas aeruginosa,its mechanisms of resistance and available treatment options.The present study provides a systemic review on major source of Pseudomonas aeruginosa in ICU.Further,study also emphasizes virulence gene/s associated with Pseudomonas aeruginosa genome for extended drug resistance.Study gives detailed overview of antibiotic drug resistance mechanism. | Preeti Pachori Ragini Gothalwal Puneet Gandhi | 2019 | Genes & Diseases2019，6，2： | 20 |
| 2 | Blood pressure-independent attenuation of cardiac hypertrophy by AT (1)R-AS gene therapy显示文摘 | Pachori AS Numan MT Ferrario CM | 2002 | Hypertension2002，39，5： | 1 |
| 3 | Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism显示文摘 | Melo LG Pachori AS Kong D | 2004 | Circulation2004，109，20： | 1 |
| 4 | Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism 显示文摘 | Melo LG Pachori AS Kong D | 2004 | Circulation2004，109，： | 1 |
| 5 | Therapeutic potential of endothelial progenitor cells in cardiovascular diseases显示文摘 | Dzau VJ Gnecchi M Pachori AS | 2005 | Hypertension2005，，： | 1 |
| 6 | Inability to induce hypertension in normotensive rat expressing AT1 R antisense 显示文摘 | Wang H | 2000 | Circ Res2000，86，： | 1 |
| 7 | Heme-oxygenase- 1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway显示文摘 | Pachori A S Smith A McDonald P | 2007 | Journal of Molecular and Cellular Cardiology2007，43，5： | 1 |
| 8 | Inability to induce hypertension in nomotensive rat express AT1 recepetor antisense显示文摘 | Pachori AS Wang H Helband CH | 2000 | Circ Res2000，86，11： | 1 |
| 9 | Classification of seizure and seizure-free EEG signals using local binary patterns 显示文摘 | KUMAR T S KANHANGAD V PACHORI R B | 2015 | Biomedi''cal Signal Processing & Control2015，15，： | 1 |
| 10 | Blood pressure-independent attenuation of cardiac hypertrophy by AT1R-AS gene therapy显示文摘 | Pachori AS Numan MT Ferrario CM | 2002 | Hypertension2002，39，5： | 1 |
| 11 | Bone morphogenetic protein 4 mediates myocardial ischemie injury through JNK - dependent signaling pathway 显示文摘 | PACHORI A S CUSTER L HANSEN D | 2010 | J Mol Cell Cardiol2010，48，6： | 1 |
| 12 | Chronic recurrent myocardial ischemic injury is significantly attenuated by preemptive adeno-associated virus heine oxygenase-1 gene delivery 显示文摘 | Pachori AS Melo LG Zhang L | 2006 | J Am Coil Cardiol2006，47，3： | 1 |
| 13 | Gene and cell-based therapies for heart disease显示文摘 | PACHORI AS KONG D | 2004 | FASEB J2004，18，6： | 1 |
| 14 | Molecular and cel-based therapies for protection,rescue,and repair of ischemic myocardium:reasons for cautious optimism显示文摘 | Melo LG Pachori AS Kong D | | 0，，20： | 1 |
| 15 | EEG signal analysis using FB expansion and second-order linear TVAR process 显示文摘 | Ram Bilas Pachori Pradip Sircar | 2008 | Signal Processing2008，88，： | 1 |
| 16 | Blood pressure-independent attenuation of cardiac hypertrophy by AT1R-As gene therapy显示文摘 | Pachori AS Numan MT Ferrario CM | 2002 | Hypertension2002，39，5： | 1 |
| 17 | Variable cosine windowing of intrinsic mode functions: Application to gear fault diagnosis 显示文摘 | Parey A Pachori R B | 2012 | Measurement2012，45，3： | 1 |
| 18 | Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heine oxygenase-1 gene delivery显示文摘 | Pachori AS Melo LG Zhang L el al | 2006 | J Am Coil Cardiol2006，47，3： | 1 |
| 19 | A new technique to reduce cross terms in the wigner distribution 显示文摘 | Pachori R B Sircar P | 2007 | Digital Signal Processing2007，17，： | 1 |
| 20 | Molecular and cell-based therapies for protection,rescue,and repair of ischemic myocardium,reasons for cautious optimism显示文摘 | Melo LG Pachori AS Kong D | 2004 | Circulation2004，109，： | 1 |
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