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59篇 您的检索式：作者名="Palendira"

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	题名	作者	年代	出处	被引量
1	Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status显示文摘BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF status.METHODS Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version 15.RESULTS Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type CRC.CONCLUSION This study has shown that CD8+ T_(RM) are found in greater abundance in MSI-H CRC, both BRAF mutant and MSI-H:BRAF wild type, when compared with their MSS counterpart. CD8+ T_(RM) may play a role in the immunogenicity in MSI-H CRC(BRAF mutant and BRAF wild type). Further studies should focus on the potential immunogenic qualities of T_(RM) cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC.	James Wei Tatt Toh Angela L Ferguson Kevin J Spring Hema Mahajan Umaimainthan Palendira	2021	World Journal of Clinical Oncology2021，12，4：	2
2	Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis显示文摘	Palendira U Kamath A T Feng C G		Infect Immun0，20，：	2
3	Impaired Epstein-Barr virusspecific CD8 + T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets显示文摘	Hislop AD Palendira U Leese AM	2010	{H}Blood2010，，17：	1
4	Coexpression of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium bovis BCG vaccines against Mycobacterium tuberculosis显示文摘	Palendira U Kamath AT Feng CG	2002	Infect Immun2002，70，4：	1
5	Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP显示文摘	Palendira U Low C Chan A		0，，11：	1
6	Improving vaccines against tubercuosis显示文摘	Brition W J Palendira U	2003	Immunol Cell Biol2003，81，：	1
7	Comparative affects of plasmid-encoded interleukin 12 and interleukin 18 on the protective efficacy of DNA vaccination against Mycobacterium tuberculosis 显示文摘	Triccas J A Sun L Palendira U	2002	Immunol Cell Biol2002，80，4：	1
8	Priming by DNA immunization augments protective efficacy of Mycobacterium boris bacille calmetteguerin against tuberculosis 显示文摘	Feng C G Palendira U Demangel C	2001	Infect Immun2001，69，6：	1
9	Improving vaccines against tuberculosis 显示文摘	Britton WJ Palendira U	2003	Immunol Cell Biol2003，81，1：	1
10	Comparative affects of plasmid-encoded interleukin-12 and interleukin 18 on the protective efficacy of DNA vaccination against Mycobacterium tuberculosis 显示文摘	Triccas JA Sun L Palendira U	2002	Immunol Cell Biol2002，80，4：	1
11	Priming by DNA immunization augments protective efficacy of Mycobacterium boris bacille calmette-guerin against tuberculosis 显示文摘	Feng C G Palendira U C Demangel J M	2001	Infect Immun2001，69，6：	1
12	Improving vaccines against tuberculosis显示文摘	Britton WJ Palendira U	2003	Immunol Cell Biol2003，81，1：	1
13	Impaired Epstein- Barr virus-specific CD8+F-cell functionin X-linked lym- phoproliferative disease is restricted to SLAM family-pos- itive b-cell targets显示文摘	Hislop AD Palendira U Leese AM	2010	Blood2010，116，17：	1
14	Comparative effects of plasmid encoded interleukin 12 and interleukin 18 on the protective efficacy of DNA vaccination against Mycobacterium tuberculosis显示文摘	Triccal JA Sun L Palendira U	2002	Immunol Cell Biol2002，80，4：	1
15	Comparative affects of plasmid-encoded interleukin-12 and interleukin 18 on the protective efficacy of DNA vaccination against Mycobacterium tuberculosis显示文摘	Triccas JA Sun L Palendira U	2002	Immunol Cell Biol2002，80，4：	1
16	Coexpresslon of interleukin-12 chains by a self-splicing vector increases the protective cellular immune response of DNA and Mycobacterium boris BCG vaccines against Mycobacterium tuberculosis 显示文摘	Palendira U Kamath AT Feng CG	2002	Infect Immun2002，70，4：	1
17	Comparative affects of plasmid-eneoded interleukin 12 and interleukin 18 on the protective efficacy of DNA vaccination against Mycobacterium tuberculosis显示文摘	Triccas JA Sun L Palendira U	2002	Immunol Cell Biol2002，80，4：	1
18	Improving vaccines against tuberculosis显示文摘	Britton W J Palendira U	2003	Immunol Cell Biol2003，81，1：	1
19	Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis显示文摘	Feng CG Palendira U Demangel C	2001	Infect Immun2001，69，6：	1
20	Impaired Epstein Barr virus specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets 显示文摘	Hisiop AD Palendira U Leese AM	2010	Blood2010，116，17：	1

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