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| 1 | 黄芪植入可控降解胶原支架控释促血管生成的效应显示文摘目的:将中药黄芪载入胶原支架内,通过对胶原支架进行修饰,观察黄芪能否代替生长因子起到促进血管生成疗效,并了解黄芪与生长因子是否有协同作用。方法:实验于2004-07-01/2006-07-01在德国亚琛工业大学生化研究所及江苏省中医院中心实验室进行。首先通过不同的EDC/NHS与肝素钠比例来交链修饰Ⅰ型胶原(EDC与NHS质量比固定为1∶0.6,EDC与肝素钠比例为0.2￣4),然后将1mL黄芪注射液(相当于3mg生药黄芪)载入修饰后的胶原内。体外通过甲苯胺蓝法测定修饰后胶原内肝素含量,胶原酶降解法测量胶原体外降解率,同时对胶原的亲水性及自由氨基团进行测定。体内通过鸡胚绒毛尿囊膜模型进行血管计数及血红蛋白测定。结果:①体外实验结果:通过对胶原的修饰程度,可以控制胶原内的肝素含量、体外降解率、自由氨基团含量、亲水性大小。②体内实验结果:黄芪注射液1mL载入修饰后的胶原较载入未修饰的胶原,可以明显促进鸡胚绒毛尿囊膜内微血管生成,提高胶原内血红蛋白含量(P<0.01),其疗效与重组人体血管内皮生长因子载入修饰后的胶原内相当,且与血管内皮生长因子有协同作用的趋势。结论:通过对胶原的修饰来控制胶原的体外降解,载入黄芪后,使黄芪促血管生成疗效增强,达到与血管内皮生长因子载入后的疗效相当,其作用机制有待进一步研究。 | 陈晓虎 姚昶 Andreas Groerge 黄峻 朱永康 潘立群 唐蜀华 许芝银 N Pallua GCM Steffens | 2007 | 中国组织工程研究与临床康复2007，11，31： | 13 |
| 2 | 黄芪对肝素修饰后胶原促血管再生的影响显示文摘目的:血管再生已经成为治疗心脏搭桥手术不能完全缓解的严重冠状动脉疾病的新型治疗措施。本研究主要探讨中药黄芪、血管内皮生长因子载入修饰后的胶原促血管再生的疗效,并探求黄芪与生长因子有无协同作用。方法:以定量计数胶原周围微血管再生数量、胶原内血红蛋白含量、胶原干重、对胶原内血管生长的病理免疫组化标记等指标来考察黄芪对肝素修饰后胶原促血管再生的作用。结果:黄芪联合肝素修饰后的胶原能够产生与血管内皮生长因子相当的疗效,联合运用黄芪和血管内皮生长因子具有协同作用的趋势。结论:就血管再生疗效而言,黄芪在本胶原中可以替代或增加血管内皮生长因子的疗效。 | 陈晓虎 姚昶 Andreas Groerge 黄峻 N Pallua GCM Steffens | 2007 | 中国天然药物2007，5，5： | 6 |
| 3 | Vascular reliability of nip- pleareola complex-bearing pedicles: An anatomical microdissec- tion study 显示文摘 | O'Dey D Prescher A Pallua N | 2007 | Plast Reconstr Surg2007，119，： | 1 |
| 4 | The effect of cross- linking of collagen matrices on their angiogenic capability 显示文摘 | Yao C Markowicz M Pallua N | 2008 | Biomaterials2008，29，1： | 1 |
| 5 | Efficacy and safety of polyacrylamide hydrogel for facial soft-tissue augmentation 显示文摘 | von Buelow S yon Heimburg D Pallua N | 2005 | Plast Reconstr Surg2005，116，4： | 1 |
| 6 | Beneficial effect of corticosteroids in catecholamine-dependent septic burn patients显示文摘 | Fuchs P Ch Bozkurt A Johnen D Smeets R Groger A Pallua N | 2007 | Burns2007，33，： | 1 |
| 7 | A 5-year assessment of safety and aesthetic results after facial soft-tissue augmentation with polyacrylamide hydrogel (Aquamid) : a prospective multicenter study of 251 pa- tients显示文摘 | Pallua N Wolter TP | 2010 | Plast Reconstr Surg2010，125，6： | 1 |
| 8 | The lipo- facelift: merging the face- lift and liposculpture: eight years experience and a preliminary observa- tional study显示文摘 | Pallua N Wolter T | 2013 | Aesthetic Plast Surg2013，37，6： | 1 |
| 9 | Improvement of facial scar appearance and microeirculation by autologous lipofilling 显示文摘 | Pallua N Baroncini A Alharbi Z | 2014 | J Plast Reconstr Aesthet Surg2014，67，8： | 1 |
| 10 | The tunneled supraclavicular island flap: an optimized technique for head and neck reconstruction 显示文摘 | Pallua N Magnus Noah E | 2000 | Plast Reconstr Surg2000，105，3： | 1 |
| 11 | 'Reconstruction of the face and neck scar contractures using staged transfer of expanded ' Super-thin flaps 显示文摘 | PALLUA N | 2008 | Burns2008，34，5： | 1 |
| 12 | Pre-expanded ultra-thin supraclavicular flaps for (full-) face reconstruction with reduced donor-site morbidity and without the need for microsurgery 显示文摘 | Pallua N von Heimburg D | 2005 | Plast Reconstr Surg2005，115，7： | 1 |
| 13 | The fasciocutaneoussupraclavicular artery island flap for releasing postbum mentostemalcontractures显示文摘 | Pallua N Machens HG Kennekampff 0 | 1997 | Plast Reconstr Surg1997，99，： | 1 |
| 14 | The anterior Obturator Artery Perforator (aOAP)flap:surgical anatomy and application of a method for vulvar reconstruction显示文摘 | O' Dey D M Bozkurt A Pallua N | 2010 | Gynecol Oncol2010，119，： | 1 |
| 15 | Attenuated corticomedullary contrast:An early cerebral computed tomography sign indicating malignant middle cerebral artery infarction,A case-control study显示文摘 | Haring HP Dilitz E Pallua A | 1999 | Stroke1999，30，5： | 1 |
| 16 | 'I' becomes 'L':modification of vertical mammaplasty显示文摘 | PALLUA N ERMISCH C | 2003 | Plast Reconstr Surg2003，111，6： | 1 |
| 17 | 显示文摘 | Gfieb G Steffens G Pallua N | 2011 | Int Rev Cell Mol Biol2011，291，： | 1 |
| 18 | The ALT chimera flap : expanding the indications 显示文摘 | Fuchs PC Wolter TP Pallua N | 2010 | Eur J Plast Surg2010，33，2： | 1 |
| 19 | Angiogenic strategies in tissue engineering: Differentiation of human bone marrow stem cells in modified collagen 显示文摘 | Markowicz M Koellensperger E Pallua N | 2004 | Angiogenesis2004，7，2： | 1 |
| 20 | The use of bifunctional polyethyleneglycol derivatives for coupling of proteins to and cross-linking of collagen matrices显示文摘 | J.-S. Chen E. M. Noah N. Pallua G. C. M. Steffens | 2002 | Journal of Materials Science: Materials in Medicine2002，，11： | 1 |
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