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| 1 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | Effect of short-term treatment with regular or high doses of omeprazole on the detection of Helicobacter pylori in bleeding peptic ulcer patients显示文摘 | Udd M Miettinen P Palmu A | 2003 | Scand J Gastroenterol2003，38，： | 1 |
| 3 | Development of Coke-oven Battery Process Management System at Rautaruukki Steelworks 显示文摘 | SWANIJUNG J PALMU P | 1996 | Iron and Steel Engineer1996，73，1： | 1 |
| 4 | Efficacy of a pneumococcal conjugate vaccine against acute otitis media显示文摘 | Eskola J Kilpi T Palmu A | | 0，，06： | 1 |
| 5 | Efficacy of a pneumococcal conjugate vaccine against acute otitis media显示文摘 | Eskola J Kilpi T Palmu A | 2001 | N Engl J Med2001，344，6： | 1 |
| 6 | Efficacy of a pneumococcal conjugate vaccine against acute otitis media显示文摘 | Eskola J Kilpi T Palmu A | 2001 | N Engl J Med2001，344，： | 1 |
| 7 | Composite films made with gelatin,tracetin,stearic and caproic acids : effect of pH and surfactants addition on the functionality of films 显示文摘 | Davanco T Tanada - Palmu P Grosso C | 2007 | Ciencia E Tecnologia De Alimentos2007，27，2： | 1 |
| 8 | Effect of short - term treat- ment with regular or high doses of omeprazole on the detection of Helieo- baeter pylori in bleeding peptic ulcer patients 显示文摘 | Udd M Miettinen P Palmu A | 2003 | Stand J Gastroen-terol2003，38，6： | 1 |
| 9 | Real-time quantitative PCR for the detection of Streptococcus pneumoniae in the middle ear fluid of children with acute otitis media显示文摘 | Saukkoriipi A Palmu A Kilpi T | 2002 | Mol Cell Probes2002，16，5： | 1 |
| 10 | Real-time quantitative PCR for the detection of streptococcus pneumoniae in the middle ear fluid of children with acute otitis media 显示文摘 | Saukkoriipi A Palmu A Kilpi T | 2002 | Molecular and Cellular Probes2002，16，： | 1 |
| 11 | Normative values for tympanometry in 7- and 24-month-old children显示文摘 | Palmu A Puhakka H Huhtala H | 2001 | Audiology2001，40，4： | 1 |
| 12 | Expression in Pichia pas- toffs and purification of AspergiUus awamori glucoamylase catalytic domain 显示文摘 | Heimo H Palmu K Suominen I | 1997 | Protein expression and purification1997，10，1： | 1 |
| 13 | Mental disorders af- ter burn injury: a prospective study 显示文摘 | Palmu R Suominen K Vuola J | 2011 | Burus2011，37，4： | 1 |
| 14 | Incidence and etiolo- gy of community-acquired pneumonia in the elderly in a prospective population-based study显示文摘 | Palmu A A Saukkoriipi A Snellman M | 2014 | Scandinavian journal of infectious diseases2014，46，4： | 1 |
| 15 | Development of Coke-oven Battery Process Management System at Rautaruukki Steelworks显示文摘 | SWANLJUNG J PALMU P | 1996 | Ⅰ-ron and Steel Engineer1996，73，1： | 1 |
| 16 | Incidence and etiology of community-acquired pneumonia in the elderly in a prospective population-based study 显示文摘 | Palmu A A Saukkoriipi A Snellman M | 2014 | Scandinavian journal of infectious diseases2014，46，4： | 1 |
| 17 | Efficacy of a pneumococcal conjugate vaccine against acute otitis media显示文摘 | Eskola J Kilpi T Palmu A | 2001 | N Engl J Med2001，344，6： | 1 |
| 18 | Analysis of the risk factors andtheir combinations in acute gastroduodenal ulcer bleedingiacase-control study 显示文摘 | Udd M Miettinen P Palmu A | 2010 | Scandinavian Journal of Gastroenterology2010，，12： | 1 |
| 19 | Concentration and high avidity of pneumococcal antibodies persist at least 4 years after immunization with pneumococcal conjugate vaccine in infancy显示文摘 | Ekstrm N Ahman H Palmu A Grnholm S | | 0，，07： | 1 |
| 20 | Efficacy of a pneumococcal con-jugate vaccine against acute otitis media 显示文摘 | Eskola J Kilpi T Palmu A | 2001 | N Engl J Med2001，344，40： | 1 |
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