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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Rolo of vitamin D in the pathogenesis of type 2 diabetes melitus显示文摘 | Palomer X Gonzale CM Blanco VF | | 0，，03： | 1 |
| 3 | Targeting endoplasmic reticulum stress in insulin resistance显示文摘 | Laia Salvado Xavier Palomer | 2015 | Cell2015，26，： | 1 |
| 4 | Role of vitamin D in the pathogenesis of type 2 diabetes mellitus 显示文摘 | Palomer X Gonzalez-Clemente JM Blanco VF | 2008 | Diatetes Obes Metab2008，10，3： | 1 |
| 5 | Resveratrol induces nuclear factor-KB activity in human cardiac cells显示文摘 | Xavier Palomer Eva Capdevila-Busquets David ?lvarez-Guardia | 2013 | International Journal of Cardiology2013，167，6： | 1 |
| 6 | Role of vi- tamin D in the pathogenesis of type 2 diabetes mellitus 显示文摘 | Palomer X Gonzalez-Clemente J M Blaneo-Vaea F | 2008 | Diabetes Obes Metab2008，10，3： | 1 |
| 7 | Role of vitamin D in the pathogenesis of type 2 diabetes mellitus显示文摘 | Palomer X Gonzdez-Clemente JM Blanco-Vaca F | | 0，，03： | 1 |
| 8 | Sleep-disordered breathing:radiofrequency thermal ablation is a promising new treatment possibility显示文摘 | B(a)ck L Palom(a)ki M Piilonen A | 2001 | Laryngoscope2001，111，3： | 1 |
| 9 | Poststroke depression:an 18-month follow-up显示文摘 | Palom(a)ki H Lehtihalmes M | 2003 | Stroke2003，34，： | 1 |
| 10 | An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy显示文摘 | Palomer X Salvado L Barmso E | 2013 | Int J Cardiol2013，168，4： | 1 |
| 11 | Poststroke depression:an 18-month follow-up显示文摘 | Berg A Palom?ki H Lehtihalmes M | | 0，，： | 1 |
| 12 | Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis显示文摘 | Pohjantfihti-Maaroos H Palom/iki A Hartikainen J | 2011 | BMC Cardiovasc Disord2011，11，： | 1 |
| 13 | Erwinia carotovora subsp, ca- rotovora and erwinia -derived elicitors hrpN and pehA trigger distinct but interacting defense responses and cell death in Arabidopsis 显示文摘 | Kariola T Palom T A Brader G | 2003 | The American Phytopathological Society2003，16，3： | 1 |
| 14 | Role of vitamin 0 in the pathogenesis of type 2 diabetes mellitus显示文摘 | Palomer X Gonzalez-Clemente IM B1anco-Vaca F | 2008 | Diabetes Obes Metab2008，10，3： | 1 |
| 15 | Role of vitamin D in the pathogenesis of type 2 diabetes mellitus 显示文摘 | Palomer X Gonztlez - Clemente JM Blanco - Vaca F | 2008 | Diabetes ObesMetab2008，10，3： | 1 |
| 16 | Role of vitamin D in the pathogenesis of type 2 diabetes mellitus显示文摘 | Palomer X González Clemente J M Blanco Vaca F | 2008 | Diatetes Obes Metab2008，10，3： | 1 |
| 17 | Role of vitamin D in the pathogenesis of type 2 diabetes mellitus显示文摘 | Palomer X Gonz61ez-Clemente J M Blanco-Vaca F | 2008 | Diabetes Obes Metab2008，10，18： | 1 |
| 18 | The p65 subunit of NF-kappaB binds to PGC 1alpha,linking inflammation and metabolic disturbances in cardiac cells显示文摘 | Alvarez-Guardia D Palomer X Coll T | | 0，，03： | 1 |
| 19 | Role of vitam in D in the pathogenes is of type 2 diabetes mellitus显示文摘 | Palomer X Gonzalez-Clemente JM Blanco-Vaca F | 2008 | Diabetes Obes Metab2008，10，3： | 1 |
| 20 | Sleep-disor dered breathing: radiofrequency thermal ablation is a promising new treatment possibility显示文摘 | Maarit Palom ki Anneli Piilonen | 2001 | Laryngoscope2001，111，： | 1 |
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