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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Visual mapping by high resolution FISH显示文摘 | Heiskanen M Pehonen L Palotie A | 1996 | Trends Genet1996，12，10： | 1 |
| 3 | Regulation of sex hormone-binding globulin production by isoflavonoids and patterns of isoflavonoid conjugation in HepG2 cell cultures显示文摘 | Loukovaara M Carson M Palotie A | 1995 | Steroids1995，60，9： | 1 |
| 4 | Head to tail organization of the human COL6A1 and COL6A2 genes by fiber-FISH 显示文摘 | Heiskanen M Saitta B Palotie A | 1995 | Genomics1995，29，3： | 1 |
| 5 | Long-chain 3-hydroxyacylCoA dehydrogenase deficiency with G1528C mutation:Clinical presentation in 13 patients显示文摘 | Tyni T Palotie A Viinikka L | 1997 | J Pediatr1997，130，： | 1 |
| 6 | Early onset OA lin ked to the type Ⅱ procollagen gene显示文摘 | VIKKULA M PALOTIE A RITRANIEMI P | 1993 | Arthritis Rheum1993，36，3： | 1 |
| 7 | Genetic Risk Prediction and a 2-Stage Risk Screening Strategy for Coronary Heart Disease显示文摘 | Emmi Tikkanen Aki S. Havulinna Aarno Palotie Veikko Salomaa Samuli Ripatti | 2013 | Arteriosclerosis, Thrombosis, and Vascular Biology2013，，： | 1 |
| 8 | Visual mapping by high resolution FISH 显示文摘 | HEISKANEN M PELTONEN L PALOTIE A | 1996 | Trends in Genet- ics1996，12，10： | 1 |
| 9 | Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation显示文摘 | Malinen T Palotie A Pakkala S | 1991 | Blood1991，77，11： | 1 |
| 10 | Visual Mapping by High Resolution FISH显示文摘 | Peltonen L Palotie A | 1996 | Trends in Genetics1996，12，： | 1 |
| 11 | Fiber-FISH : experiences and a refined protocol显示文摘 | Heiskanen M Kallioniemi O Palotie A | 1996 | Engineering1996，12，： | 1 |
| 12 | Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation显示文摘 | Malinen T Palotie A Pakkala S | 1991 | Blood1991，77，11： | 1 |
| 13 | Predisposition to familial osteoarthrosis linked to type Ⅱ collagen gene 显示文摘 | Palotie A Vaisanen P Ott J | 1989 | Lancet1989，1，8644： | 1 |
| 14 | Visual mapping by high resolution FISH 显示文摘 | Heiskanen M Peltonen L Palotie A | 1996 | Trends in Genetics1996，12，10： | 1 |
| 15 | High-resolntiun fluorescence in situ hybridization:a new approach in genome mapping显示文摘 | Heiskanen M Laan M | 1996 | Ann Med1996，28，： | 1 |
| 16 | IFITM3 restricts the morbidity and mor- tality associated with iniluenza显示文摘 | Everitt A R Clare S Pertel T John S P Wash R S Smith S E Chin C R Feeley E M Sims J S Adams DJ Wise H M Kane L Goulding D Digard P Anttila V Baillie J K Walsh T S Hume D A Palotie A Xue Y Colonna V Tyler-Smith C Dunning J Gor- don S B GenlSIS Investigators MOSAIC Investiga- tors Smyth R L Openshaw PJ Dougan G Brass A L Kellam P | 2012 | Nature2012，484，7395： | 1 |
| 17 | Novel Human Vascular Endothelial Growth Factor Genes VEGF-B and VEGF-C Localize to Chromosomes 11q13 and 4q34, Respectively显示文摘 | Karri BMed Paavonen Nina Horelli-Kuitunen Dimitri Chilov Eola Kukk Sari Pennanen Olli-Pekka Kallioniemi Katri Pajusola Birgitta Olofsson Ulf Eriksson Vladimir Joukov Aarno Palotie Kari Alitalo | 1996 | Circulation1996，，6： | 1 |
| 18 | Use of population isolates for mapping complex traits显示文摘 | Peltonen L Palotie A Lange K | 2000 | Nature Reviews Genetics2000，1，： | 1 |
| 19 | Describing the genetic architecture of epilepsy through heritability analysis显示文摘 | Speed D O'Brien TJ Palotie A | 2014 | Brain2014，24，7： | 1 |
| 20 | Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘 | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | Cancer Res2003，63，11： | 1 |
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