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| 1 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 2 | Viral evasion of DNA-stimulated innate immune responses显示文摘导出病毒的 nucleic 酸的细胞的察觉到为对病毒感染的早防卫是必要的。在最近的年里,包括周期的 GMP 安培 synthase (cGAS ) 和 gamma-interferon-inducible 蛋白质(IFI16 ) ,察觉到蛋白质的 DNA 的发现导致了房间怎么对带 DNA 染色体的到来的病原体唤起强壮的天生的有免疫力的回答的理解。发信号由 DNA 传感器刺激了取决于适配器蛋白质圈套(干扰素基因的激发器) ,到启用抗病毒的蛋白质的表示,包括类型我干扰素。便于有效感染,病毒发展了大量避免策略,指向的主人 DNA 传感器,适配器蛋白质和抄写因素。在这评论, STING 小径的导致病毒的激活上的当前的文学被介绍,我们讨论在这条抗病毒的小径指向不同的步的最近识别的病毒的避免机制。 | Maria H Christensen Sфren R Paludan | 2017 | Cellular & Molecular Immunology2017，14，1： | 4 |
| 3 | Dendritic cells cross present latency gene products from Epstein-Barr virustransformed B cells and expand tumor-reactive CD8(+) killer T cells显示文摘 | Subklewe M Paludan C Tsang ML | 2001 | J Exp Med2001，193，： | 1 |
| 4 | Endogenous MHC class Ⅱ processing of a viral nuclear antigen after autophagy显示文摘 | Paludan C Schmid D Landthaler M | 2005 | Science2005，307，5709： | 1 |
| 5 | Co-morbidity index predicts for mortality after stereotactic body radiotherapy for medically inoperable early-stage non-small cell lung cancer显示文摘 | KOPEK N PALUDAN M PETERSEN J | | 0，，03： | 1 |
| 6 | Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model显示文摘 | Howard KA Paludan SR Behlke MA | 2009 | Mol Ther2009，7，1： | 1 |
| 7 | Endogenous MHC class II processing of a viral nuclear antigen after autophagy显示文摘 | Paludan C Schmid D Landthaler M Vockerodt M Kube D Tuschl T Münz C | 2005 | Science2005，307，5709： | 1 |
| 8 | Interleukin-4 and IFN-γ: the quint essence of amutual antagonistic relationship 显示文摘 | Paludan SR | 1998 | Scand J Immunol1998，48，5： | 1 |
| 9 | Endogenous MHC class II processing of a viral nuclear antigen after autophagy显示文摘 | Paludan C Schmid D Landthaler M | 2005 | Science2005，307，5709： | 1 |
| 10 | Endogenous MHC class Ⅱ processing of a viral nuclear antigen after autophagy显示文摘 | Paludan C Schmid D Landthaler M | 2005 | Science2005，307，5709： | 1 |
| 11 | Endogenous MHC class Ⅱ processing of a viral nuclear antigen after autophagy显示文摘 | Paludan C Schmid D Landthaler M | 2005 | Science2005，307，5709： | 1 |
| 12 | Distribution and speciation of phosphorus along a salinity gradient in intertidal marsh sediments显示文摘 | Claus Paludan James T. Morris | 1999 | Biogeochemistry1999，，2： | 1 |
| 13 | Significance of age and comorbidity on treatment modality, treatment adherence, and prognosis in elderly ovarian cancer patients 显示文摘 | Jorgensen TL Teiblum S Paludan M | 2012 | Gynecol On- col2012，127，： | 1 |
| 14 | Losses of inorganic carbon and nitrous oxide from a temperate freshwater wetland in relation to nitrate loading显示文摘 | PALUDAN C BLICHER-MATHIESEN G | 1996 | Biogeochemistry1996，35，2： | 1 |
| 15 | Reading the viral signature by Toll-like receptors and other pattern recognition receptors显示文摘 | Mogensen TH Paludan SR | 2005 | J Mol Med ( Berl )2005，83，3： | 1 |
| 16 | Carnation mottle virus demonstrated in Begonia etatior and Begonia x cheimantha showing vein clearing, leaf curl and flower break显示文摘 | Paludan N Begtrup J | 1985 | ta Horticulturae1985，164，： | 1 |
| 17 | Requirements for the induction of interleukin-6 by herpes simplex virus-infected leukocytes 显示文摘 | Paludan SR | 2001 | J Virol2001，75，17： | 1 |
| 18 | Distribution and speciation of phosphorus along a salinity gradient in intertidal marsh sediments显示文摘 | Paludan C Morris J T 1999 | 1999 | Biogeochemistry1999，45，： | 1 |
| 19 | Induction of interferon-stimulated genes by Chlamydia pneumoniae in fibroblasts is mediated by intracellular nucleotide-sensing receptors显示文摘 | Chiliveru S Birkelund S Paludan SR | 2010 | PLoS One2010，5，10： | 1 |
| 20 | Endogenous MHC class Ⅱ processing of a viral nuclear antigen after autophagy显示文摘 | Paludan C Schmid D Landthaler M Vockerodt M Kube D Tuschl T | 2005 | Science2005，307，： | 1 |
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