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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | 对上面的胃肠的道的活动性混乱的基因贡献显示文摘 Motility disorders of the upper gastrointestinal tract encompass a wide range of different diseases. Esophageal achalasia and functional dyspepsia are representative disorders of impaired motility of the esophagus and stomach, respectively. In spite of their variable prevalence, what both diseases have in common is poor knowledge of their etiology and pathophysiology. There is some evidence showing that there is a genetic predisposition towards these diseases, especially for achalasia. Many authors have investigated the possible genes involved, stressing the autoimmune or the neurological hypothesis, but there is very little data available. Similarly, studies supporting a post-infective etiology, based on an altered immune response in susceptible individuals, need to be validated. Further association studies can help to explain this complex picture and find new therapeutic targets. The aim of this review is to summarize current knowledge of genetics in motility disorders of the upper gastrointestinal tract, addressing how genetics contributes to the development of achalasia and functional dyspepsia respectively. | Giovanni Sarnelli Alessandra D’Alessandro Marcella Pesce Ilaria Palumbo Rosario Cuomo | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，4： | 3 |
| 3 | Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence显示文摘 | Emilio Quaia Mirko D'Onofrio Alessandro Palumbo Stefania Rossi Stefano Bruni Maria Cova | 2006 | European Radiology2006，，7： | 2 |
| 4 | The effect of grain size on the wear properties of electrodeposited nanocrystalline nickel coatings显示文摘 | Jeong D H Gonzalez F Palumbo G | 2001 | Seripta Mater2001，44，3： | 1 |
| 5 | The effect of gauge volume on the tensile properties of nanocrystalline electrodeposits 显示文摘 | Wei H Hibb G D Palumbo G | 2007 | Scripta Materialia2007，57，11： | 1 |
| 6 | Advances in ReversedNested Miller Compensation 显示文摘 | Grasso A D Palumbo G Pennisi S | 2007 | IEEE Transactions onCircuits and Systems I : Regular Papers2007，54，7： | 1 |
| 7 | DNA topoisomerase IIstructures and anthracycline activity: insights into ternary com-plex formation显示文摘 | Dal Ben D Palumbo M Zagotto G | 2007 | Curr Pharm Des2007，13，27： | 1 |
| 8 | Radiculopathy and myelopathy at segments adjacent to the site of a previous anteri- or cervical arthrodesis显示文摘 | Hilibrand A S Carlson G D Palumbo M A | 1999 | J Bone Joint Surg Am1999，81，4： | 1 |
| 9 | Morphofunctional and clinical study on mandibular alveolar distraction osteogenesis 显示文摘 | Zaffe D Bertoldi C Palumbo C | 2002 | Clin Oral hnpl Res2002，13，4： | 1 |
| 10 | Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis显示文摘 | Hilibrand A S Carlson G D Palumbo M A | 1999 | J Bone Joint Surg Am1999，81，4： | 1 |
| 11 | Relaxing effects of Valeri- ana offieinalis extracts on isolated human non-pregnant uterine muscle 显示文摘 | OCCHIUTO F PINO A PALUMBO D R | 2009 | J Pharm Pharroaeo12009，61，2： | 1 |
| 12 | Mutagenesis of beta-1, 3-glucanase genes in Lysobacter enzymogenes strain C3 results in reduced biological control activity to- ward Bipolaris leaf spot of tall fescue and Pythium damping-off of sugar beet 显示文摘 | Palumbo J D Yuen G Y Jochum C C | 2005 | Phytopathology2005，95，： | 1 |
| 13 | The effect of grain size on the wear properties of electrodeposhed nanoorystalline nickel coatings显示文摘 | Jeong D H Gonzalez F Palumbo G | | Scripta Mater0，44，： | 1 |
| 14 | On improving the corrosion and growth resistance of positive Pbacid battery grids by grain boundary engineering显示文摘 | LEHOCKEY E M LIMOGES D PALUMBO G | 1999 | Journal of Power Source1999，78，： | 1 |
| 15 | The effects of grain size on the wear properties of electrodeposited nanocrystalline nickel coatings显示文摘 | Jeong D H Gonzalez F Palumbo G | 2001 | Scripta Mater2001，44，3： | 1 |
| 16 | Effects of tree windbreak on microclimate and wheat productivity in a Mediterranean environment显示文摘 | Campi P Palumbo A D Mastrorilli M | 2009 | European Journal of Agronomy2009，30，3： | 1 |
| 17 | Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults显示文摘 | Pasqualini D Bergandi L Palumbo L | 2012 | J Endod2012，38，12： | 1 |
| 18 | Bortezomib?melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezornib?melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trial显示文摘 | Palumbo A Bringhen S Rossi D | 2010 | J Clin Oncol2010，28，34： | 1 |
| 19 | InguindHomiop Lasty: the gold standard of hernia repair显示文摘 | Forte A D Llrso A Palumbo Lo Storto G | 2003 | Hernia2003，7，1： | 1 |
| 20 | 2006 Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones显示文摘 | Palumbo M O Levi D Chentoufi A A Polychronakos C | 2006 | Diabetes2006，55，9： | 1 |
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