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43篇 您的检索式：作者名="Pan Chin"

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	题名	作者	年代	出处	被引量
1	Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients显示文摘BACKGROUND An increased amount of Fusobacterium nucleatum(F.nucleatum)is frequently detected in the gastric cancer-associated microbiota of the Taiwan Residents population.F.nucleatum is known to exert cytotoxic effects and play a role in the progression of colorectal cancer,though the impact of F.nucleatum colonization on gastric cancer cells and patient prognosis has not yet been examined.AIM To identify F.nucleatum-dependent molecular pathways in gastric cancer cells and to determine the impact of F.nucleatum on survival in gastric cancer.METHODS Coculture of F.nucleatum with a gastric cancer cell line was performed,and changes in gene expression were investigated.Genes with significant changes in expression were identified by RNA sequencing.Pathway analysis was carried out to determine deregulated cellular functions.A cohort of gastric cancer patients undergoing gastrectomy was recruited,and nested polymerase chain reaction was performed to detect the presence of F.nucleatum in resected cancer tissues.Statistical analysis was performed to determine whether F.nucleatum colonization affects patient survival.RESULTS RNA sequencing and subsequent pathway analysis revealed a drastic interferon response induced by a high colonization load.This response peaked within 24 h and subsided after 72 h of incubation.In contrast,deregulation of actin and its regulators was observed during prolonged incubation under a low colonization load,likely altering the mobility of gastric cancer cells.According to the clinical specimen analysis,approximately one-third of the gastric cancer patients were positive for F.nucleatum,and statistical analysis indicated that the risk for colonization increases in late-stage cancer patients.Survival analysis demonstrated that F.nucleatum colonization was associated with poorer outcomes among patients also positive for Helicobacter pylori(H.pylori).CONCLUSION F.nucleatum colonization leads to deregulation of actin dynamics and likely changes cancer cell mobility.Cohort analysis demonstrated that F.nucleatum colonization leads to poorer prognosis in H.pylori-positive patients with late-stage gastric cancer.Hence,combined colonization of F.nucleatum and H.pylori is a predictive biomarker for poorer survival in late-stage gastric cancer patients treated with gastrectomy.	Yung-Yu Hsieh Shui-Yi Tung Hung-Yu Pan Te-Sheng Chang Kuo-Liang Wei Wei-Ming Chen Yi-Fang Deng Chung-Kuang Lu Yu-Hsuan Lai Cheng-Shyong Wu Chin Li	2021	World Journal of Gastroenterology2021，27，42：	3
2	A pilot study of nursing activities on the chest medicine ward at KMCH显示文摘	Pan SM Chin CC Hwang SC etal	1993	Kao Hsiung I Hsueh Ko Hsueh Tsa Chin1993，9，4：	1
3	The microstrueture and phase equilibrium of new high performance high - entropy alloys 显示文摘	Ker - Chang Hsieh Cheng - Fu Yu Wen - Tai Hsieh Wei - Ren Chiang Jin Son Ku Jiun -Hui Lai Chin -Pan T Chih Chao Yang	2008	Journal of Alloys and Compounds2008，，8：	1
4	Flow pattern transition instability in a microchannel with CO2 bubbles produced by chemical reaction显示文摘	Fu B R Pan Chin	2005	International Journal of Heat and Mass Transfer2005，48，2122：	1
5	Bio-activity-guided isolatio of cytotoxic constituents of Brucea javanica collected in Vietnam显示文摘	Li Pan Young-Won Chin Hee-Byung Chai	2009	Bioor&Medicinal Chem2009，17，6：	1
6	Analysis of Two-Phase Flow Characteristics in a Natural Circulation Loop Using the Drift-Flux Model Taking Flow Pattern Change and Subcooled Boiling into Consideration显示文摘	Jeng H R Pan Chin	1999	Annals of Nuclear Energy1999，26，14：	1
7	Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam显示文摘	Li Pan Young-Won Chin Hee-Byung Chai	2009	Bioorg&Medicinal Chem2009，17，6：	1
8	Application of Wavelet theory to identify yielding in seismic response of bi-linear structures 显示文摘	Tso-Chien Pan Chin Long Lee	2002	Earthquake Engineering and Structural Dynamics2002，31，：	1
9	A modified sealed over-UV method of COD determination显示文摘	Chen Junming Pan Tengchang Huang Chin wang	1994	Toxicol Environ Health1994，40，4：	1
10	Effects of neutralizing agents on lactic acid production by Rhizopus oryzae using sweet potato starch显示文摘	Hong Wei Yen Tsia Ju Chen Wei Chin Pan	2010	World J Microbiol Biotechnol2010，26，3：	1
11	Nonlinear Dynamics of a Nuclear-Coupled Boiling Channel with Forced Flows显示文摘	Lin Y N Lee J D Chin Pan	1998	Nuclear Engineering and Design1998，179，：	1
12	Bio- activity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam 显示文摘	Li Pan Young-Won Chin Hee-Byung Chai	2009	Bioorg Med Chem2009，17，6：	1
13	A Multilevel Investigation of Missing Links between Transformational Leadership and Task Performance= The Mediating Roles of Per- ceived Person-Job Fit and Person-Organization Fit 显示文摘	CHIN W PAN S Y	2012	Journal of Business and Psychology2012，27，1：	1
14	Human amniotic fluid mesenchymal stem cells in combination with hyperbaric oxygen augment peripheral nerve regeneration 显示文摘	Pan HC Chin CS Yang DY	2009	Neurochem Res2009，34，7：	1
15	Bubble dynamics in microchannels, Part II: Two parallel microchannels 显示文摘	Li H Y Tseng F G Pan Chin	2004	International Journal of Heat and Mass Transfer2004，47，：	1
16	Nonlinear analysis for a double-channel two-phase natural circulation loop under low-pressure conditions显示文摘	Jin Der Lee Chin Pan	2005	Ann Nucl Energy2005，32，：	1
17	Bioactivity-guided isolation of eytotoxic constituents of Bruceajavanica collected in Vietnam显示文摘	Pan L Chin Y-W Chai H-B etal	2009	Bioorg Medicinal Chem2009，17，6：	1
18	Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam显示文摘	Pan L Chin Y W Chai H B	2009	Bioorg Med Chem2009，17，6：	1
19	Bioactivity-guided iso- lation of cytotoxic constituents of Brucea javanica collected in Vietnam显示文摘	Pan L Chin YW Chai HB	2009	Bioorg Med Chem2009，17，6：	1
20	Nonlinear Analysis for a Nuclearcoupled Two-phase Natural Circulation Loop显示文摘	Jin Der Lee Chin Pan	2005	Nuclear Engineering and Design2005，235，：	1

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