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| 1 | Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease显示文摘 | Tang B Xiong H Sun P Zhang Y Wang D Hu Z Zhu Z Ma H Pan Q Xia JH Xia K Zhang Z | 2006 | 中国生物学文摘2006，20，8： | 30 |
| 2 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 3 | The compression of IR spectra by using wavelet neural network显示文摘IR spectra play an important role in determining the structure of compounds qualitatively andquantitatively.In general a great number of data are required to exactly show the features ofthe compounds.Regarding various compounds,there are massive IR spectra.With the basicfeatures of IR spectra being reserved,it is important to compress IR spectra for improving thestorage,index and process of IR spectra.The wavelet neural network(WNN)is a newneural network model based on wavelet analysis.However,its introduction and applica-tion in chemistry have not been reported.In this note,WNN is applied to the compression ofthe IR spectra of polystyrene.The results show that the original spectra can be | Liu, W Li, JP Xiong, JH Pan, ZX Zhang, MS | 1997 | Chinese Science Bulletin1997，42，10： | 8 |
| 4 | Thymidine kinase gene mutation leads to reduced virulence of pseudorabies virus显示文摘To explore correlation between the tk gene structure of pseudorabies virus (PRV) and its virulence, to study the effect of the gene mutation on PRV biological properties, and to investigate mechinism of reduced virulence, thymidine kinase (TK)-deficient mutant of pseudorabies virus strain Hubei (PRV HB) was isolated by selection for resistance to 5-bromodeoxyuridine. The tk genes of PRV HB and its TK mutant were cloned and sequenced. 1587 base pairs of the tk gene and flanking regions of wild-type (wt) virus were sequenced, which included an open reading frame (ORF) of 1098 bp encoding a protein of 366 amino acids. The ORF contained two 137-bp repeated sequences, which were connected by an adenosine. 1458 bp of the tk and flanking regions of TK- mutant were sequenced. Analysis of the tk gene sequence of TK mutant indicated that one of 137 bp repeated sequence and the connecting adenosine in the tk gene of the wt virus was deleted and a repeated sequence of 8 nucleotides (GCGCGCC) was inserted. All | Pan, ZS Zhang, CY Ding, JH Min, P | 2001 | Chinese Science Bulletin2001，46，23： | 2 |
| 5 | Effects of intermedin(1-53)on cardiac function and ischemia/reperfusion injury in isolated rat hearts显示文摘 | Yang JH Jia YX Pan CS | 2005 | Biochem Biophys Res Commun2005，327，： | 1 |
| 6 | Transitional cell carcinoma in dialysis patients显示文摘 | OU JH PAN CC LIN JS | 2000 | Eur Urol2000，37，1： | 1 |
| 7 | Association ofBLCA-4 Hypomethylati- on in Blood Leukocyte DNA and the Risk of Bladder Cancer in a Chinese Population显示文摘 | Ji HX Zhao Q Pan JH | 2013 | Pathol Oncol Res2013，19，5： | 1 |
| 8 | Safety and immunogenicity of a malaria vaccine, Plasmodiumfalciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adults显示文摘 | Hu JH Chen ZH Pan WQ | 2008 | PLoS ONE2008，3，4： | 1 |
| 9 | Intermedin1-53 activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas显示文摘 | Yang JH Pan CS Jia YX | 2006 | Biochem Biophys Res Commun2006，341，2： | 1 |
| 10 | Comparative effects of recombinanthuman brain natriuretic peptide and dobutamine on acutedecompensated heart failure patients with different blood BNP levels显示文摘 | Pan HY Zhu JH Gu Y | 2014 | BMC Cardiovasc Disord2014，14，： | 1 |
| 11 | Recognition property and preparation of Staphylococcus aureus protein A-imprinted polyacrylamide polymers by inverse-phase suspension and bulk polymerization显示文摘 | Pan J Xue XH Wang JH | 2009 | Polymer2009，50，11： | 1 |
| 12 | Angiotensin-converting enzyme gene 2 350 G/A polymorphism is associated with left ventricular hypertrophy but not essential hypertension 显示文摘 | PAN M ZU JH LIU ZH | 2007 | Hypertens Res2007，30，1： | 1 |
| 13 | Ezetimibe inhibits the incorporation of dietary oxidize cholesterol into lipoproteins显示文摘 | Staprans I Pan XM Rapp JH | 2006 | J Lipid Res2006，47，11： | 1 |
| 14 | Cerebral ischemia and infarction from atheroemboli < 100 microm in size显示文摘 | Rapp JH Pan XM Yu B | 2003 | Stroke2003，34，： | 1 |
| 15 | IL-19, IL-20 and IL-24: potential therapeutic targets for autoimmune diseases 显示文摘 | Leng RX Pan HF Tao JH | 2011 | Expert Opin Ther Targets2011，15，2： | 1 |
| 16 | Lecithin-based nano-emulsification improves the bioavailability of conjugated linoleic acid显示文摘 | Wan H Kim JH Pan JH | 2016 | J Agric Food Chem2016，64，6： | 1 |
| 17 | Antitumormechanism of evodiamine a constituent from Chinese herb Evodiae fructus in human muhiple-drug resistant breast NCI/ADR-RES cells in vitro and in vivo 显示文摘 | Liao CH Pan SL Guh JH | 2005 | Carcinogenesis2005，26，5： | 1 |
| 18 | A pilot study applying digital radiography for estimating ratio of supported sin- gle-root surface area 显示文摘 | Chen SK Pan JH Lin CH | 2005 | J Periodontol2005，76，2： | 1 |
| 19 | The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion 显示文摘 | Pan SL Tao KY Gdh JH | 2008 | Shock2008，30，5： | 1 |
| 20 | Immtmogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity 显示文摘 | Barouch DH Pan MG Custers JH | 2004 | J Immunol2004，172，10： | 1 |
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