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| 1 | Chronic functional constipation is strongly linked to vitamin D deficiency显示文摘BACKGROUND Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined.AIM To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders.METHODS We performed a prospective case-control study, from May-June to November2017. Glucose/lactulose breath tests, radiopaque markers(multiple capsule techniques) and wireless motility capsule analysis were used to assess colonicand oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life(IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14(HADS-14 A and HADS-14 D).RESULTS We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels(P < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests(IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group(P < 0.001), which significantly correlated with low vitamin D levels(r =-0.57, P < 0.001; r = 0.21, P = 0.01; r =-0.48, P < 0.001; r =-0.57, P < 0.001; r =-0.29, P < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder(odds ratio = 1.19; 95% confidence interval: 1.14-1.26, P < 0.001).CONCLUSION Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients. | Alba Panarese Francesco Pesce Piero Porcelli Giuseppe Riezzo Palma Aurelia Iacovazzi Carla Maria Leone Massimo De Carne Caterina Mammone Rinaldi Endrit Shahini | 2019 | World Journal of Gastroenterology2019,25,14: | 8 |
| 2 | Paediatric subglottic stenosis显示文摘 | BATH AP PANARESE A THEVASAGAYAM M | 1999 | Clin Otolaryngol1999,24,2: | 1 |
| 3 | Stapled and conventional Milligan - Morgan haemorrhoidectomy:different solu- tions for different targets 显示文摘 | PANARESE A PIRONI D VENDETTUOLI M | 2012 | Int J Colorectal Dis2012,27,4: | 1 |
| 4 | Allosteric mod- ulation of the M1 muscarinic acetylcholine receptor: impro- ving cognition and a potential treatment for schizophrenia and Alzheimer's disease 显示文摘 | Melancon B J Tarr JC Panarese JD | 2013 | Drug Discov Today2013,18,: | 1 |
| 5 | Chronic radiation-induced proctitis: the 4 % formalin application as non-surgical treatment显示文摘 | Daniele Pironi Alessandra Panarese Maurizio Vendettuoli Stefano Pontone Salvatore Candioli Annarita Manigrasso Flaminia Cristofaro Angelo Filippini | 2013 | International Journal of Colorectal Disease2013,,2: | 1 |
| 6 | Long-term outcomes of sacral nerve stimulation for fecal inconti- nence显示文摘 | George AT Kalmar K Panarese A | 2012 | Dis Colon Rectum2012,55,: | 1 |
| 7 | Helicobacter pylori eradication with either 7-day or 10-day triple therapies, and with a 10-day sequential regimen 显示文摘 | Scaccianoce G Hassan C Panarese A | 2006 | Can J Gastroenterol2006,20,2: | 1 |
| 8 | Long-term outcomes of sacral nerve stimulation for fecal incontinence显示文摘 | George AT Kalmar K Panarese A | 2012 | Dis Colon Rectum2012,55,3: | 1 |
| 9 | Chronic radiation-induced proctitis : the 4 % formalin application as non-surgical treatment 显示文摘 | Pironi D Panarese A Vendettuoli M | 2013 | Int J Colorectal Dis2013,28,2: | 1 |
| 10 | Apoptosis and proliferative activity in lymph node reaction in post- weaning multi-systemic wasting syndrome (PMWS) 显示文摘 | Mandrioli L Sarli G Panarese S | 2004 | Veterinary Immunology and Immuno-pathology2004,97,: | 1 |
| 11 | Helicobacter pylori eradication with either 7-day or 10-day triple therapies,and with a 10-day sequential regimen显示文摘 | Scaccianoce G Hassan C Panarese A | 2006 | Can J Gastroenterol2006,20,: | 1 |
| 12 | Tracking motor improve- ment at the substask level during robot-aided neurorehabilitation of stroke patients显示文摘 | Panarese A Colombo R Sterpi I | 2013 | Neurorehabilil Neural Repair2013,26,7: | 1 |
| 13 | Effect of pulsed electric field on the germination of barley seeds显示文摘 | Dymek K Dejmek P Panarese V | 2012 | Lwt- food science and technology2012,47,1: | 1 |
| 14 | Helicobacter Pylori eradication with either 7-day orl0-daytripletherapies,and with a 10-day sequential regimen显示文摘 | SCACEIANOEE G HASSAN C PANARESE A | 2006 | Can J Gast-menteml2006,20,2: | 1 |
| 15 | Modification of transverse NMR relaxation times and water diffusion coefficients of kiwifruit pericarp tissue subjected to osmotic dehydration 显示文摘 | Patricio Santagapita Luca Laghi Valentina Panarese | 2013 | Food and Bioprocess Technology2013,6,6: | 1 |
| 16 | The role of intraoperative parathyroid hormone assay in the surgical management of hyperparathyroidism显示文摘 | Romani AM Panarese A La Torre V | 2007 | Ann Ital Chir2007,78,2: | 1 |
| 17 | Microscopic studies providing insight into the mechanisms of mass transfer in vacuum impregnation显示文摘 | Panarese V Dejmek P Rocculi P | 2013 | Innovative Food Science and Emerging Technologies2013,18,: | 1 |
| 18 | Effect of osmoticdehydration on actinidia deliciosa kiwifruit: a combined nmrand ultrastructural study 显示文摘 | Panarese V Laghi L Pisi A | 2012 | Food Chemistry2012,132,4: | 1 |
| 19 | Helicobacter pylori eradication with either 7-day or 10-day triple them- pies, and with ad 10-day sequential regimen显示文摘 | Scaeeianoee G Hassan C Panarese A et 81 | 2006 | Can Gas- troenterol2006,120,: | 1 |
| 20 | Modification oftransverse nmr relaxation times and water diffusioncoefficients of kiwifruit pericarp tissue subjected to osmoticdehydration 显示文摘 | Santagapita P Laghi L Panarese V | 2012 | Food Bioprocess Technol2012,,: | 1 |