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| 1 | Association between polymorphisms in the Toll-like receptor 4,CD14,and CARD15/NOD2and inflammatory bowel disease in the Greek population显示文摘AIM: Crohn's disease(CD)and ulcerative colitis(UC)are multifactorial diseases with a significant genetic background.Apart from CARD15/NOD2 gene, evidence is accumulating that molecules related to the innate immune response such as CD14 or Toll-like receptor 4 (TLR4), are involved in their pathogenesis. In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp,Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.METHODS: DNA was obtained from 120 patients with CD,85 with UC and 100 healthy individuals. Genotyping was performed by allele specific PCR or by PCR-RFLP analysis.RESULTS: The 299Gly allele frequency of the TLR4 gene and the T allele and TT genotype frequendes of the CD14 promoter were significantly higher in CD patients only compared to healthy individuals (P = 0.026<0.05; P = 0.0048<0.01 and P= 0.047<0.05 respectively). Concerning the NOD2/CARD15mutations the overall presence in CD patients was significantly higher than that in UC patients or in controls.Additionally, 51.67% of the CD patients were carriers of a TLR4 and/or CD14 polymorphic allele and at least one variant of the NOD2/CARD15, compared to 27% of the UC patients. It should be pointed out that both frequencies significantly increased as compared with the 10% frequency of multiple carriers found in healthy controls. A possible interaction of the NOD2/CARD15 with TLR4 and especially CD14, increased the risk of developing inflammatory bowel disease (IBD).CONCLUSION: Our results indicate that co-existence of a mutation in either the TLR4 or CD14 gene, and in NOD2/CARD15is associated with an increased susceptibility to developing CD compared to UC, and to developing either CD or UC compared to healthy individuals. | Maria Gazouli Gerassimos Mantzaris Athanassios Kotsinas Panayotis Zacharatos Efstathios Papalambros Athanassios Archimandritis John Ikonomopoulos Vassilis G Gorgoulis | 2005 | World Journal of Gastroenterology2005，11，5： | 17 |
| 2 | Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients显示文摘AIM:To investigate possible associations of anti-nuclear envelope antibody(ANEA)with disease severity and survival in Greek primary biliary cirrhosis(PBC)patients.METHODS:Serum samples were collected at diagnosis from 147 PBC patients(85%female),who were followed-up for a median 89.5 mo(range 1-240).ANEA were detected with indirect immunofluorescence on 1% formaldehyde fixed Hep2 cells,and anti-gp210 antibodies were detected using an enzyme linked immunosorbent assay.Findings were correlated with clinical data,histology,and survival.RESULTS:ANEA were detected in 69/147(46.9%) patients and 31/147(21%)were also anti-gp210 positive.The ANEA positive patients were at a more advanced histological stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ56.5%/43.5% vs 74.4%/25.6%,P=0.005)compared to the ANEA negative ones.They had a higher antimitochondrial antibodies(AMA)titer(≤1:160/>1:160 50.7%/49.3%vs 71.8%/28.2%,P=0.001)and a lower survival time(91.7 ±50.7 mo vs 101.8±55 mo,P=0.043).Moreover,they had more advanced fibrosis,portal inflammation,interface hepatitis,and proliferation of bile ductules(P =0.008,P=0.008,P=0.019,and P=0.027,respectively).They also died more frequently of hepatic failure and/or hepatocellular carcinoma(P=0.016).ANEA positive,anti-gp210 positive patients had a difference in stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ54.8%/45.2%vs 74.4%/25.6%,P= 0.006),AMA titer(≤1:160/>1:160 51.6%/48.4%vs 71.8%/28.2%,P=0.009),survival(91.1±52.9 mo vs 101.8±55 mo,P=0.009),and Mayo risk score(5.5 ±1.9 vs 5.04±1.3,P=0.04)compared to the ANEA negative patients.ANEA positive,anti-gp210 negative patients had a difference in AMA titer(≤1:160/>1:160 50%/50%vs 71.8%/28.2%,P=0.002),stage(Ⅰ-Ⅱ/Ⅲ -Ⅳ57.9%/42.1%vs 74.4%/25.6%,P=0.033),fibrosis(P=0.009),portal inflammation(P=0.018),interface hepatitis(P=0.032),and proliferation of bile ductules(P=0.031).Anti-gp210 positive patients had a worse Mayo risk score(5.5±1.9 vs 4.9±1.7,P=0.038)than the anti-gp210 negative ones.CONCLUSION:The presence of ANEA and anti-gp210 identifies a subgroup of PBC patients with advanced disease severity and poor prognosis. | Ourania Sfakianaki Meri Koulentaki Maria Tzardi Elena Tsangaridou Panayotis A Theodoropoulos Elias Castanas Elias A Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，39： | 11 |
| 3 | Complications after tibia plateau fracture surgery显示文摘 | Panayiotis J. Papagelopoulos Antonios A. Partsinevelos George S. Themistocleous Andreas F. Mavrogenis Demetrios S. Korres Panayotis N. Soucacos | 2005 | Injury2005，，6： | 2 |
| 4 | 一种现代自动控制系统设计并应用于活性污泥法废水处理过程(英文)显示文摘The Activated Sludge Process(ASP) exhibits highly nonlinear properties. The design of an automatic control system that is robust against disturbance of inlet wastewater flow rate and has short process settling times is a challenging matter. The proposed control method is an I-P modi fied controller automatic control system with state variable feedback and control canonical form simulation diagram for the process. A more stable response is achieved with this type of modern control. Settling times of 0.48 days are achieved for the concentration of microorganisms,(reference value step increase of 50 mg·L-1) and 0.01 days for the concentration of oxygen(reference value step increase of 0.1 mg·L-1). Fluctuations of concentrations of oxygen and microorganisms after an inlet disturbance of5 × 103m3·d-1are small. Changes in the reference values of oxygen and microorganisms(increases by 10%, 20% and 30%) show satisfactory response of the system in all cases. Changes in the value of inlet wastewater flow rate disturbance(increases by 10%, 25%, 50% and 100%) are stabilized by the control system in short time. Maximum percent overshoot is also taken in consideration in all cases and the largest value is 25% which is acceptable. The proposed method with I-P controller is better for disturbance rejection and process settling times compared to the same method using PI controller. This method can substitute optimal control systems in ASP. | Alexandros D.Kotzapetros Panayotis A.Paraskevas Athanasios S.Stasinakis | 2015 | Chinese Journal of Chemical Engineering2015，23，8： | 2 |
| 5 | Biofuel support policies in Europe:Lessons learnt for the long way ahead显示文摘 | Tobias W Guillaume L Panayotis C | 2009 | Renewable and Sustainable Energy Reviews2009，13，4： | 1 |
| 6 | Vascularized bone graft for the management of nou-union显示文摘 | Panayotis N Soucacoe Zoe Dailians | 2006 | Injury2006，375，5： | 1 |
| 7 | Risperidone augmentation of clozapine显示文摘 | Vassilis P. Kontaxakis MD PhD Panayotis P. Ferentinos MD Beata J. Havaki-Kontaxaki MD PhD Konstantinos G. Paplos MD Dimitra A. Pappa MD George N. Christodoulou MD FICPM FRCPsych | 2006 | European Archives of Psychiatry and Clinical Neuroscience2006，，6： | 1 |
| 8 | Cro6s - lay- er resource allocation in medium - voltage broadband o- ver power - line networks 显示文摘 | Angeliki M S Athanasios ED Panayotis CC | 2012 | IEEE Transactions on Power Dellvery2012，27，4： | 1 |
| 9 | Hemiarthroplasty in the treatment of comminuted intraarticular fractures of the proxi- mal humerus显示文摘 | PANAYOTIS D NICOLAOS P ELIAS L | 1997 | Clin Orthop1997，341，： | 1 |
| 10 | Evluation of collateral sprouting after end-to-side nerve coaptation using a fluorescent double-labeling technique显示文摘 | Zhang ZJ Panayotis N Soucacos | 1999 | Microsury1999，19，： | 1 |
| 11 | Laparoscopically assisted myomec-tomy versus abdominal myomectomy in short-term outcomes:a prospec-tive study显示文摘 | Ioannis K Nikos P Panayotis X | 2013 | Archives of Gynecology and Obstetrics2013，12，5： | 1 |
| 12 | Sciatic and peroneal nerve injuries显示文摘 | Anastasios V.Korompilias Alexandros H.Payatakes Alexandros E.Beris Marios D.Vekris Gerasimos D.Afendras Panayotis N.Soucacos | 2006 | Microsurgery2006，，4： | 1 |
| 13 | construction of a triphenlyltetrazolium liquid membrane ion selective electrode and its analytical application to the assay of vitamin C显示文摘 | Panayotis G Veltstas Theodosios I Sikalos Mantas I Prodromidis | 2000 | Mikrochim Acta2000，135，： | 1 |
| 14 | Comparison of immunosuppressive therapeutic regimens in patients with nephrotic syndrome due to idiopathic membranous nephropathy显示文摘 | George Kosmadakis Vasileios Filiopoulos Despoina Smirloglou Panayotis Skarlas Christodoulos Georgoulias Spiridon Michail | 2010 | Renal Failure2010，，5： | 1 |
| 15 | Vascular anatomy and microcirculation of skeletal zones vulnerable to osteonecrosis:vascularization of the femoral head显示文摘 | Johnson EO Soultanis KS Panayotis N | | 0，，03： | 1 |
| 16 | Comparative study and categorization of high-level petri nets显示文摘 | Vasilis G Achilles K Panayotis P | 1998 | The Journal of Systems and Software1998，43，2： | 1 |
| 17 | Factors affecting the risk of hip fractures显示文摘 | Ioannis S. Benetos George C. Babis Aristides B. Zoubos Vassiliki Benetou Panayotis N. Soucacos | 2007 | Injury2007，，7： | 1 |
| 18 | Hemiarthrop last), in the treatment of comminutod intramficular fractures d the proximal humerus 显示文摘 | Panayotis D Nicolacs P EliesL | 1997 | Clin )rthop1997，，341： | 1 |
| 19 | Determination of metal content in wild edible mushroom species from regions of Greece显示文摘 | Paraskevi K O Panayotis G V Evangelos K P | 2007 | Journal of Food Composition and Analysis2007，20，6： | 1 |
| 20 | Heat shock protein 70 and HLA-DR molecules tissue expression显示文摘 | Andreas Ch. Lazaris M.D. George E. Theodoropoulos M.D. Panayotis S. Davaris M.D. Prof. Dimitris Panoussopoulos M.D. Lydia Nakopoulou M.D. Christos Kittas M.D. Prof. Basil Ch. Golematis M.D. Prof | 1995 | Diseases of the Colon & Rectum1995，，7： | 1 |
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